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Protein

Alcohol dehydrogenase class-3

Gene
N/A
Organism
Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.By similarity

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Sitei117Important for FDH activity and activation by fatty acidsBy similarity1
Metal bindingi176Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1 5640

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3By similarity (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-IIIBy similarity
Glutathione-dependent formaldehyde dehydrogenaseBy similarity (EC:1.1.1.-)
Short name:
FALDHBy similarity
Short name:
FDHBy similarity
Short name:
GSH-FDHBy similarity
S-(hydroxymethyl)glutathione dehydrogenaseBy similarity (EC:1.1.1.284)
OrganismiScyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Taxonomic identifieri7830 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004053121 – 376Alcohol dehydrogenase class-3Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP86884

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP86884
SMRiP86884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P86884-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AGTVGKVIKC KAAVAWEAGK PLCIEEIEVA PPKAHEVRIK IIATAVCHSD
60 70 80 90 100
SYTLSGSDSE GLFPVILGHE GAGIVESVGE GVTCVKAGDR VIPLYIPQCG
110 120 130 140 150
DCNFCLNPKT NLCQKIRVTQ GQGLMPDKTS RFTCKGQLLY HYMGTSTFSE
160 170 180 190 200
YTVVADISVA KIDEAAPLDK VCLLGCGIST GYGAAVNTAK VEPGSTCAVF
210 220 230 240 250
GLGGVGLAGI MGCKAAGATR IIGVDLNKDK FTKAKEFGAT EYINPKDYDK
260 270 280 290 300
PIQEVLVGLT DGGVDYSFEC IGNVKTMRAA LEACHKGWGT SVIVGVAPAG
310 320 330 340 350
HEIATRPFQL VTGRTWKGTA FGGWKSVESV PKLVKEYMAK KLKVDEFVTH
360 370
TLPFNQINES FELMHAGKSI RCVLSF
Length:376
Mass (Da):39,937
Last modified:March 8, 2011 - v1
Checksum:i36D56CECA4B3BA12
GO

Similar proteinsi

Entry informationi

Entry nameiADHX_SCYCA
AccessioniPrimary (citable) accession number: P86884
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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