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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Columba livia (Rock dove)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi175Zinc 1; catalyticBy similarity1
Binding sitei224NADBy similarity1
Binding sitei229NADBy similarity1
Binding sitei370NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1 1579

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1By similarity (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase IBy similarity
Gene namesi
Name:ADH1By similarity
OrganismiColumba livia (Rock dove)
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004053111 – 375Alcohol dehydrogenase 1Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP86883

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP86883
SMRiP86883
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P86883-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ATSGKVIRCR AAVAWAVGKP LSVEEVEVAP PKAGEVRIKI VATGICRTDD
60 70 80 90 100
HVVKGCIANV EFPVIPGHEG AGIVESIGEG VTSVKPGDKV IPLCIPNCGE
110 120 130 140 150
CTFCLNPEAS YCVKSHFSEP QNLMPDKTSR FTCKGKQIHH FMWVSTFAEY
160 170 180 190 200
TVAPETAVAK IDSAAPLDKV CLLGCGFSTG YGAAINTAKV KPGSTCAVFG
210 220 230 240 250
LGGVGLSVVM GCKVAGASRI IAIDINKDKF AKAKELGATD CINPQDFNKP
260 270 280 290 300
IQEVVTEMTG HEVDYSFEVI GRADTMIAAL ASCNMNTGVF VMVGVAPSDA
310 320 330 340 350
VISVDPLLLL TGRTHKGTLV GGSKGRNFIP RLVSSYLEKK FNSDLLITHT
360 370
LPFAKVNEGF ALLHAGKSIR TVLLF
Length:375
Mass (Da):39,598
Last modified:March 8, 2011 - v1
Checksum:iF5BB4622D3FFF860
GO

Similar proteinsi

Entry informationi

Entry nameiADH1_COLLI
AccessioniPrimary (citable) accession number: P86883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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