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Entry version 53 (29 Sep 2021)
Sequence version 1 (08 Feb 2011)
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Protein

Nestin

Gene

nes

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Required for brain and eye development.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nestin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-071119-2, nes

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Intermediate filament

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004041971 – 1265NestinAdd BLAST1265

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P86839

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed throughout the developing nervous system at 24 hours post-fertilization (hpf). As development progresses, expression becomes restricted to proliferative zones of the developing and postembryonic central nervous system. In the peripheral nervous system, expressed in the cranial ganglia. Also expressed in mesodermal muscle precursor cells and in cranial mesenchymal tissue.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is not detected before the 3-somite stage at 10-11 hours post-fertilization. Earliest expression is detected during mid-neurulation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000088805, Expressed in embryo and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, preferentially forms heterodimers (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000112046

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P86839

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 324IF rodPROSITE-ProRule annotationAdd BLAST308

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 16HeadSequence analysisAdd BLAST16
Regioni17 – 52Coil 1ASequence analysisAdd BLAST36
Regioni53 – 64Linker 1Sequence analysisAdd BLAST12
Regioni65 – 160Coil 1BSequence analysisAdd BLAST96
Regioni161 – 183Linker 12Sequence analysisAdd BLAST23
Regioni184 – 203Coil 2ASequence analysisAdd BLAST20
Regioni204 – 206Linker 2Sequence analysis3
Regioni207 – 324Coil 2BSequence analysisAdd BLAST118
Regioni325 – 1265TailSequence analysisAdd BLAST941
Regioni383 – 521DisorderedSequence analysisAdd BLAST139
Regioni667 – 830DisorderedSequence analysisAdd BLAST164
Regioni863 – 1073DisorderedSequence analysisAdd BLAST211
Regioni1093 – 1116DisorderedSequence analysisAdd BLAST24
Regioni1232 – 1265DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi383 – 403Polar residuesSequence analysisAdd BLAST21
Compositional biasi404 – 422Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi423 – 441Polar residuesSequence analysisAdd BLAST19
Compositional biasi447 – 475Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi476 – 499Polar residuesSequence analysisAdd BLAST24
Compositional biasi674 – 698Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi715 – 729Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi778 – 830Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi865 – 901Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi909 – 933Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi934 – 954Polar residuesSequence analysisAdd BLAST21
Compositional biasi959 – 976Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi977 – 1048Polar residuesSequence analysisAdd BLAST72
Compositional biasi1057 – 1073Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1242 – 1256Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RYFK, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_274633_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P86839

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQASHMD

Database of Orthologous Groups

More...
OrthoDBi
78144at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P86839

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR031211, Nestin

The PANTHER Classification System

More...
PANTHERi
PTHR47051, PTHR47051, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038, Filament, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P86839-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELLGVRQPF GPQFQEEKYQ MLELNHRLES YLGRVKLLEE ENKLLREEIH
60 70 80 90 100
TLKSSRDPAG QRKAQEEALS QARRMMEEAW RKKDCVELEV ENLMEDMEKV
110 120 130 140 150
SFQRKKVKTA QAEAQRKLTE SRKELEEERR AQIWLREKVG QLEKDLMLQM
160 170 180 190 200
QVHQENMETM QASLKQTKQV LMAPQRVQAT SIPDLGQEYG YKAAQAWQEA
210 220 230 240 250
ANNYQKQVGR LEESLNQTKA NMTKIYQEKR ESQRQVQHLA KELESTRIKR
260 270 280 290 300
QMLEKHAMQQ REEQKEELQH LQAQVNTLEL EKDCLGQQID SLMLDRQHLL
310 320 330 340 350
QVKMSLGLEV ATYRALLDSE GLRIDRPTPN KTSSTVFLDA LSKPTGIQST
360 370 380 390 400
SQTTAASCLL SSSVSTSHRS IASSRSLLTS AAPSWTLTRG TPQRPPSSTS
410 420 430 440 450
MTEKTEDHIS EETKRSAEES VDQLQQEKVQ QDWTLESTLP KTSAEPKPEL
460 470 480 490 500
QPEEIKVEDE ANEPQQAHMV ESKTDESELT SVPAEQQGSM SQTPETKSWA
510 520 530 540 550
GHFNDPAEVS EDGKDEDTEV SVEMARISHA PKVAWEEIKS AVEDEKDDAS
560 570 580 590 600
EMDVRSEIIS ESHTFAYGDA ENDSNTLTSS HISQNTNALA SSFLEQGTLD
610 620 630 640 650
SASYFGYEAT NENLMKEEEL DNVSNISEEV TEQLNSETEA AIDSINEWDR
660 670 680 690 700
QEESEPENET KVMTSYFEVE EGEMSINTDT KDKTEDDIER EELEVTEREI
710 720 730 740 750
LVQSAGGMLG VDLPNDTDHQ DEHNLPQIEL NEDQSEAEEE NQKEKQCDED
760 770 780 790 800
DSPNISASLK TDPGEGDSYS QEHTLADTRP LIRYKSDEET SHHIGETSDS
810 820 830 840 850
EDEKERIDQG HLNEKRFNTM EDLTEEPDME VTGKMRLEDL VSNEEAAADD
860 870 880 890 900
VASVMFQKVS GDHESLDVVV QESERKGNLE KEDSGDADNM RDNKEEDVSV
910 920 930 940 950
FEQNENQQLT EHQHVHTEQV EDKPVHSHET QEHVNTEFSS TFSERSQQEQ
960 970 980 990 1000
LEESSLTMFE DEAATKEAED SDVSMHTNID LIDSRSLESE INGQPDIMTS
1010 1020 1030 1040 1050
DMANSECNSS EDESPNASQC FQNTSLLAAA TPNEQPLTFT NEVSKADYVS
1060 1070 1080 1090 1100
DNNDVPEEVL SEEKSTDEPK ASQIDDLENF NIWGESTSIS DAAQTTHASM
1110 1120 1130 1140 1150
DEHSSISPVN ENLESSNKIP SVAENIFGHF EEHLERSVES FPEKEVTVMD
1160 1170 1180 1190 1200
FENNDLGEEF QSKQMKSEIH SFFSTSLKQD FWSEGKMEMA ATYDPAKTED
1210 1220 1230 1240 1250
LNQAMVFGEE WREIGVQSAN GDTKEEMEIL KIRDDKQKDG QPAQSKIVQS
1260
DDSADEGDSW SSGDE
Length:1,265
Mass (Da):143,400
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28F7142CCB4A2715
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR848841 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001919922.1, XM_001919887.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000122681; ENSDARP00000112046; ENSDARG00000088805

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100150939

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:100150939

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848841 Genomic DNA No translation available.
RefSeqiXP_001919922.1, XM_001919887.6

3D structure databases

SMRiP86839
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112046

Proteomic databases

PaxDbiP86839

Genome annotation databases

EnsembliENSDART00000122681; ENSDARP00000112046; ENSDARG00000088805
GeneIDi100150939
KEGGidre:100150939

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10763
ZFINiZDB-GENE-071119-2, nes

Phylogenomic databases

eggNOGiENOG502RYFK, Eukaryota
GeneTreeiENSGT00940000167106
HOGENOMiCLU_274633_0_0_1
InParanoidiP86839
OMAiTQASHMD
OrthoDBi78144at2759
PhylomeDBiP86839

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P86839

Gene expression databases

BgeeiENSDARG00000088805, Expressed in embryo and 15 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR031211, Nestin
PANTHERiPTHR47051, PTHR47051, 2 hits
PfamiView protein in Pfam
PF00038, Filament, 1 hit
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEST_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P86839
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 29, 2021
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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