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Protein

Hementerin

Gene
N/A
Organism
Haementeria depressa (Leech)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves fibrinogen Aalpha (FGA), gamma (FGG) and Bbeta (FGB) chains. Degrades cross-linked fibrin. Has no amidolytic, plasminogenolytic or caseinolytic activity. Inhibits platelet aggregation induced by collagen (IC50=7.5ug/ml) and various other agonists, presumably via activation of a nitridergic pathway. Inhibition is accompanied by reduced ATP release from and surface expression of SELP and CD63 on platelets as well as increased intracellular levels of Ca2+, cGMP and nitric oxide synthase activity.2 Publications

Caution

The order of the peptides shown is unknown.1 Publication

Cofactori

Ca2+1 Publication

Activity regulationi

Fibrino(geno)lytic activity inhibited by EDTA but not by PMSF, E-64, 6-AHA and aprotinin.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processBlood coagulation, Fibrinolysis, Hemostasis
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Hementerin1 Publication (EC:3.4.-.-)
OrganismiHaementeria depressa (Leech)
Taxonomic identifieri279730 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudineaHirudinidaGlossiphoniiformesGlossiphoniidaeHaementeria

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003979381 – ›30HementerinAdd BLAST›30

Sequencei

Sequence statusi: Fragments.

P86682-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30
XTLSEPEPTC SIEYFRYQAI EDCEYSISVK
Length:30
Mass (Da):3,513
Last modified:October 5, 2010 - v1
Checksum:i5A492FA070690DD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-adjacent residuesi9 – 101 Publication2
Non-adjacent residuesi16 – 171 Publication2
Non-terminal residuei301 Publication1

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiHETN_HAEDE
AccessioniPrimary (citable) accession number: P86682
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 12, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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