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Entry version 68 (12 Aug 2020)
Sequence version 1 (20 Apr 2010)
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Protein

Proline-rich protein 20A

Gene

PRR20A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P86496

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline-rich protein 20ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRR20A
Synonyms:PRR20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204919.1

Human Gene Nomenclature Database

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HGNCi
HGNC:24754, PRR20A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P86496

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000204919

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165505473

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P86496, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRR20A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003360921 – 221Proline-rich protein 20AAdd BLAST221

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P86496

PRoteomics IDEntifications database

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PRIDEi
P86496

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57779

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P86496

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P86496

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204919, Expressed in testis and 2 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P86496, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204919, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125761, 27 interactors
609653, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000438757

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P86496, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 71Pro-richAdd BLAST50
Compositional biasi59 – 95Arg-richAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRR20 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TFGJ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_117010_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P86496

Identification of Orthologs from Complete Genome Data

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OMAi
GRPTEPF

Database of Orthologous Groups

More...
OrthoDBi
1355106at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P86496

TreeFam database of animal gene trees

More...
TreeFami
TF341860

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031439, PRR20

The PANTHER Classification System

More...
PANTHERi
PTHR38819, PTHR38819, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15708, PRR20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P86496-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEPRPSKRL RSMAPNQASG GPPPEPGCCV ADPEGSVEAD GPAQPAQPAK
60 70 80 90 100
PIAYVKPFRR QPPARPESPP PAERGRRRGG SRRPGRGRGR RAGPRGDAGQ
110 120 130 140 150
RQGAEGLMAP DVHIQLDHHG EPGHQGEPEI TETAAFSLSE TGPPPGTVQE
160 170 180 190 200
GPGPDVAQPE LGFQEPPAAP GPQAVDWQPV LTLYPCIGFR ALGDSAVLQV
210 220
IQTPQGTYVQ GVPVFLTDIA Y
Length:221
Mass (Da):23,262
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE870312E6F1D607F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097615 mRNA No translation available.
AL353652 Genomic DNA No translation available.
BC120931 mRNA Translation: AAI20932.1
BC120932 mRNA Translation: AAI20933.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31981.1

NCBI Reference Sequences

More...
RefSeqi
NP_001123876.1, NM_001130404.1
NP_001123877.1, NM_001130405.1
NP_001123878.1, NM_001130406.1
NP_001123879.1, NM_001130407.1
NP_940843.1, NM_198441.2
XP_016855016.1, XM_016999527.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377931; ENSP00000367164; ENSG00000204919

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
122183
729233
729240
729246
729250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:122183
hsa:729233
hsa:729240
hsa:729246
hsa:729250

UCSC genome browser

More...
UCSCi
uc010thd.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097615 mRNA No translation available.
AL353652 Genomic DNA No translation available.
BC120931 mRNA Translation: AAI20932.1
BC120932 mRNA Translation: AAI20933.1
CCDSiCCDS31981.1
RefSeqiNP_001123876.1, NM_001130404.1
NP_001123877.1, NM_001130405.1
NP_001123878.1, NM_001130406.1
NP_001123879.1, NM_001130407.1
NP_940843.1, NM_198441.2
XP_016855016.1, XM_016999527.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125761, 27 interactors
609653, 17 interactors
STRINGi9606.ENSP00000438757

PTM databases

iPTMnetiP86496
PhosphoSitePlusiP86496

Polymorphism and mutation databases

BioMutaiPRR20A

Proteomic databases

PaxDbiP86496
PRIDEiP86496
ProteomicsDBi57779

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
67109, 18 antibodies

Genome annotation databases

EnsembliENST00000377931; ENSP00000367164; ENSG00000204919
GeneIDi122183
729233
729240
729246
729250
KEGGihsa:122183
hsa:729233
hsa:729240
hsa:729246
hsa:729250
UCSCiuc010thd.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
122183
729233
729240
729246
729250
EuPathDBiHostDB:ENSG00000204919.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRR20A
HGNCiHGNC:24754, PRR20A
HPAiENSG00000204919, Tissue enriched (testis)
neXtProtiNX_P86496
OpenTargetsiENSG00000204919
PharmGKBiPA165505473

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TFGJ, Eukaryota
GeneTreeiENSGT00390000001542
HOGENOMiCLU_117010_0_0_1
InParanoidiP86496
OMAiGRPTEPF
OrthoDBi1355106at2759
PhylomeDBiP86496
TreeFamiTF341860

Enzyme and pathway databases

PathwayCommonsiP86496

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
122183, 9 hits in 448 CRISPR screens
729233, 5 hits in 61 CRISPR screens
729240, 5 hits in 63 CRISPR screens
729246, 6 hits in 63 CRISPR screens
729250, 6 hits in 101 CRISPR screens
PharosiP86496, Tdark

Protein Ontology

More...
PROi
PR:P86496
RNActiP86496, protein

Gene expression databases

BgeeiENSG00000204919, Expressed in testis and 2 other tissues
GenevisibleiP86496, HS

Family and domain databases

InterProiView protein in InterPro
IPR031439, PRR20
PANTHERiPTHR38819, PTHR38819, 1 hit
PfamiView protein in Pfam
PF15708, PRR20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPR20A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P86496
Secondary accession number(s): Q8N7V5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: August 12, 2020
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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