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UniProtKB - P86479 (PR20C_HUMAN)

Entry version 70 (10 Feb 2021)
Sequence version 1 (20 Apr 2010)
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Protein

Proline-rich protein 20C

Gene

PRR20C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P86479

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline-rich protein 20CCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRR20CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:37221, PRR20C

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P86479

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000229665.8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000204919

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165505473

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P86479, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRR20C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003938921 – 221Proline-rich protein 20CAdd BLAST221

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57776

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P86479

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P86479

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000229665, Expressed in testis and 2 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P86479, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000229665, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125761, 99 interactors
609637, 90 interactors
609643, 90 interactors
609649, 90 interactors
609653, 103 interactors

Protein interaction database and analysis system

More...IntActi		P86479, 26 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P86479, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 71Pro-richSequence analysisAdd BLAST50
Compositional biasi59 – 95Arg-richSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRR20 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_117010_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P86479

Identification of Orthologs from Complete Genome Data

More...OMAi		PNGTYVQ

Database of Orthologous Groups

More...OrthoDBi		1355106at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P86479

TreeFam database of animal gene trees

More...TreeFami		TF341860

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031439, PRR20

The PANTHER Classification System

More...PANTHERi		PTHR38819, PTHR38819, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15708, PRR20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P86479-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEPRPSKRL RSMAPNQASG GPPPEPGCCV ADPEGSVEAD GPAQPAQPAK 
        60         70         80         90        100
PIAYVKPFRR QPPARPESPP PAERGRRRGG SRRPGRGRGR RAGPRGDAGQ 
       110        120        130        140        150
RQGAEGLMAP DVHIQLDHHG EPGHQGEPEI TETAAFSLSE TGPPPGTVQE 
       160        170        180        190        200
GPGPDVAQPE LGFQEPPAAP GPQAVDWQPV LTLYPCIGFR ALGDSAVLQV 
       210        220 
IQTPQGTYVQ GVPVFLTDIA Y
Length:221
Mass (Da):23,262
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE870312E6F1D607F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL353652 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45054.1

NCBI Reference Sequences

More...RefSeqi		NP_001123876.1, NM_001130404.1
NP_001123877.1, NM_001130405.1
NP_001123878.1, NM_001130406.1
NP_001123879.1, NM_001130407.1
NP_940843.1, NM_198441.2
XP_016855016.1, XM_016999527.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000544357; ENSP00000438757; ENSG00000229665
ENST00000614894; ENSP00000480729; ENSG00000229665

Database of genes from NCBI RefSeq genomes

More...GeneIDi		122183
729233
729240
729246
729250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:122183
hsa:729233
hsa:729240
hsa:729246
hsa:729250

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353652 Genomic DNA No translation available.
CCDSiCCDS45054.1
RefSeqiNP_001123876.1, NM_001130404.1
NP_001123877.1, NM_001130405.1
NP_001123878.1, NM_001130406.1
NP_001123879.1, NM_001130407.1
NP_940843.1, NM_198441.2
XP_016855016.1, XM_016999527.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125761, 99 interactors
609637, 90 interactors
609643, 90 interactors
609649, 90 interactors
609653, 103 interactors
IntActiP86479, 26 interactors

PTM databases

iPTMnetiP86479
PhosphoSitePlusiP86479

Genetic variation databases

BioMutaiPRR20C

Proteomic databases

ProteomicsDBi57776

Genome annotation databases

EnsembliENST00000544357; ENSP00000438757; ENSG00000229665
ENST00000614894; ENSP00000480729; ENSG00000229665
GeneIDi122183
729233
729240
729246
729250
KEGGihsa:122183
hsa:729233
hsa:729240
hsa:729246
hsa:729250

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		122183
729233
729240
729246
729250

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRR20C
HGNCiHGNC:37221, PRR20C
HPAiENSG00000229665, Tissue enriched (testis)
neXtProtiNX_P86479
OpenTargetsiENSG00000204919
PharmGKBiPA165505473
VEuPathDBiHostDB:ENSG00000229665.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

HOGENOMiCLU_117010_0_0_1
InParanoidiP86479
OMAiPNGTYVQ
OrthoDBi1355106at2759
PhylomeDBiP86479
TreeFamiTF341860

Enzyme and pathway databases

PathwayCommonsiP86479

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		122183, 10 hits in 446 CRISPR screens
729233, 5 hits in 74 CRISPR screens
729240, 6 hits in 78 CRISPR screens
729246, 7 hits in 79 CRISPR screens
729250, 8 hits in 118 CRISPR screens
PharosiP86479, Tdark

Protein Ontology

More...PROi		PR:P86479
RNActiP86479, protein

Gene expression databases

BgeeiENSG00000229665, Expressed in testis and 2 other tissues
GenevisibleiP86479, HS

Family and domain databases

InterProiView protein in InterPro
IPR031439, PRR20
PANTHERiPTHR38819, PTHR38819, 1 hit
PfamiView protein in Pfam
PF15708, PRR20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPR20C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P86479
Secondary accession number(s): Q8N7V5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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