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Protein

Zinc finger BED domain-containing protein 6

Gene

ZBED6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).By similarity

Miscellaneous

Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 187BED-type 1PROSITE-ProRule annotationAdd BLAST58
Zinc fingeri264 – 321BED-type 2PROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 61 Publication
Gene namesi
Name:ZBED61 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000257315.1
HGNCiHGNC:33273 ZBED6
MIMi613512 gene
neXtProtiNX_P86452

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100381270
OpenTargetsiENSG00000257315
PharmGKBiPA165752811

Polymorphism and mutation databases

BioMutaiZBED6
DMDMi292495573

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003925731 – 979Zinc finger BED domain-containing protein 6Add BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei381PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP86452
MaxQBiP86452
PaxDbiP86452
PeptideAtlasiP86452
PRIDEiP86452
ProteomicsDBi57774

PTM databases

iPTMnetiP86452
PhosphoSitePlusiP86452

Expressioni

Gene expression databases

BgeeiENSG00000257315 Expressed in 90 organ(s), highest expression level in intestine
GenevisibleiP86452 HS

Organism-specific databases

HPAiHPA068807

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1147772, 4 interactors
IntActiP86452, 4 interactors
STRINGi9606.ENSP00000447879

Structurei

3D structure databases

ProteinModelPortaliP86452
SMRiP86452
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni866 – 948HATC (Hobo-Ac-Tam3) domainAdd BLAST83

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 187BED-type 1PROSITE-ProRule annotationAdd BLAST58
Zinc fingeri264 – 321BED-type 2PROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IR9U Eukaryota
ENOG410YAJD LUCA
GeneTreeiENSGT00530000063354
InParanoidiP86452
OMAiKTSAVWN
OrthoDBiEOG091G0B61
PhylomeDBiP86452
TreeFamiTF322818

Family and domain databases

InterProiView protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 2 hits
SMARTiView protein in SMART
SM00614 ZnF_BED, 2 hits
SUPFAMiSSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 2 hits

Sequencei

Sequence statusi: Complete.

P86452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVCTLSVPV SSLSPGRRCN TFSDSGILGC VPINSNTDEE DVVEEKMVAE
60 70 80 90 100
GVNKEAKQPA KKKRKKGLRI KGKRRRKKLI LAKKFSKDLG SGRPVADAPA
110 120 130 140 150
LLASNDPEQD EESLFESNIE KQIYLPSTRA KTSIVWHFFH VDPQYTWRAI
160 170 180 190 200
CNLCEKSVSR GKPGSHLGTS TLQRHLQARH SPHWTRANKF GVASGEEDFT
210 220 230 240 250
LDVSLSPSSG SNGSFEYIPT DPLDDNRMGK KHDKSASDAL RAERGRFLIK
260 270 280 290 300
SNIVKHALIP GTRAKTSAVW NFFYTDPQHI SRAVCNICKR SVSRGRPGSH
310 320 330 340 350
LGTSTLQRHL QATHPIHWAV ANKDSGAVAN GLDEAETERS DLLSDTLHGE
360 370 380 390 400
KSTGSQDLTA EDLSDSDSDE PMLEVENRSE SPIPVAEQGT LMRAQERETT
410 420 430 440 450
CCGNPVSSHI SQAIIQMIVE DMHPYNYFST PAFQRFMQIV APDYRLPSET
460 470 480 490 500
YFFTKAVPQL YDCVREKIFL TLENVQSQKI HLTVDIWTHD PSTDYFIVTV
510 520 530 540 550
HWVSLETASF LNNGRIPDFR KWAVLCVTGL AKDCLITNIL QELNDQIGLW
560 570 580 590 600
LSPNFLIPSF IVSDNSSNVV HAIKDGGFTH VPCFLHCLNM VIQDFFCEHK
610 620 630 640 650
SIENMLVAAR KTCHHFSHSV KARQILQEFQ NDHQLPWKNL KQDETGHWIS
660 670 680 690 700
TFYMLKWLLE HCYSVHHSLG RASGVVLTSL QWTLMTYVCD ILKPFEEATQ
710 720 730 740 750
KVSVKTAGLN QVLPLIHHLL LSLQKLREDF QVRGITQALN LVDSLSLKLE
760 770 780 790 800
TDTLLSAMLK SKPCILATLL DPCFKNSLED FFPQGADLET YKQFLAEEVC
810 820 830 840 850
NYMESSPEIC QIPTSEASCP SVTVGADSFT SSLKEGTSSS GSVDSSAVDN
860 870 880 890 900
VALGSKSFMF PSAVAVVDEY FKEKYSEFSG GDDPLIYWQR KISIWPALTQ
910 920 930 940 950
VAIQYLSCPM CSWQSECIFT KNSHFHPKQI MSLDFDNIEQ LMFLKMNLKN
960 970
VNYDYSTLVL SWDPEQNEVV QSSEKEILP
Length:979
Mass (Da):109,973
Last modified:March 23, 2010 - v1
Checksum:i48D5B5EE9AFDC2A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114402 Genomic DNA No translation available.
CCDSiCCDS55673.1
RefSeqiNP_001167579.1, NM_001174108.2

Genome annotation databases

EnsembliENST00000550078; ENSP00000447879; ENSG00000257315
GeneIDi100381270
KEGGihsa:100381270
UCSCiuc021phs.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114402 Genomic DNA No translation available.
CCDSiCCDS55673.1
RefSeqiNP_001167579.1, NM_001174108.2

3D structure databases

ProteinModelPortaliP86452
SMRiP86452
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1147772, 4 interactors
IntActiP86452, 4 interactors
STRINGi9606.ENSP00000447879

PTM databases

iPTMnetiP86452
PhosphoSitePlusiP86452

Polymorphism and mutation databases

BioMutaiZBED6
DMDMi292495573

Proteomic databases

EPDiP86452
MaxQBiP86452
PaxDbiP86452
PeptideAtlasiP86452
PRIDEiP86452
ProteomicsDBi57774

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550078; ENSP00000447879; ENSG00000257315
GeneIDi100381270
KEGGihsa:100381270
UCSCiuc021phs.2 human

Organism-specific databases

CTDi100381270
DisGeNETi100381270
EuPathDBiHostDB:ENSG00000257315.1
GeneCardsiZBED6
H-InvDBiHIX0159983
HGNCiHGNC:33273 ZBED6
HPAiHPA068807
MIMi613512 gene
neXtProtiNX_P86452
OpenTargetsiENSG00000257315
PharmGKBiPA165752811
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR9U Eukaryota
ENOG410YAJD LUCA
GeneTreeiENSGT00530000063354
InParanoidiP86452
OMAiKTSAVWN
OrthoDBiEOG091G0B61
PhylomeDBiP86452
TreeFamiTF322818

Miscellaneous databases

GeneWikiiZBED6
PROiPR:P86452
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000257315 Expressed in 90 organ(s), highest expression level in intestine
GenevisibleiP86452 HS

Family and domain databases

InterProiView protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 2 hits
SMARTiView protein in SMART
SM00614 ZnF_BED, 2 hits
SUPFAMiSSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBED6_HUMAN
AccessioniPrimary (citable) accession number: P86452
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 7, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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