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Entry version 71 (11 Dec 2019)
Sequence version 1 (23 Mar 2010)
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Protein

Zinc finger BED domain-containing protein 6

Gene

ZBED6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).By similarity

Miscellaneous

Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri130 – 187BED-type 1PROSITE-ProRule annotationAdd BLAST58
Zinc fingeri264 – 321BED-type 2PROSITE-ProRule annotationAdd BLAST58

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 61 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBED61 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000257315.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33273 ZBED6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613512 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P86452

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100381270

Open Targets

More...
OpenTargetsi
ENSG00000257315

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165752811

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P86452 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZBED6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
292495573

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003925731 – 979Zinc finger BED domain-containing protein 6Add BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei381PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P86452

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P86452

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P86452

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P86452

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P86452

PeptideAtlas

More...
PeptideAtlasi
P86452

PRoteomics IDEntifications database

More...
PRIDEi
P86452

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57774

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P86452

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P86452

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000257315 Expressed in 90 organ(s), highest expression level in intestine

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P86452 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA068807

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
1147772, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P86452, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000447879

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P86452 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P86452

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni866 – 948HATC (Hobo-Ac-Tam3) domainAdd BLAST83

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 187BED-type 1PROSITE-ProRule annotationAdd BLAST58
Zinc fingeri264 – 321BED-type 2PROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR9U Eukaryota
ENOG410YAJD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163411

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P86452

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTSAVWN

Database of Orthologous Groups

More...
OrthoDBi
223749at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P86452

TreeFam database of animal gene trees

More...
TreeFami
TF322818

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00614 ZnF_BED, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50808 ZF_BED, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P86452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVCTLSVPV SSLSPGRRCN TFSDSGILGC VPINSNTDEE DVVEEKMVAE
60 70 80 90 100
GVNKEAKQPA KKKRKKGLRI KGKRRRKKLI LAKKFSKDLG SGRPVADAPA
110 120 130 140 150
LLASNDPEQD EESLFESNIE KQIYLPSTRA KTSIVWHFFH VDPQYTWRAI
160 170 180 190 200
CNLCEKSVSR GKPGSHLGTS TLQRHLQARH SPHWTRANKF GVASGEEDFT
210 220 230 240 250
LDVSLSPSSG SNGSFEYIPT DPLDDNRMGK KHDKSASDAL RAERGRFLIK
260 270 280 290 300
SNIVKHALIP GTRAKTSAVW NFFYTDPQHI SRAVCNICKR SVSRGRPGSH
310 320 330 340 350
LGTSTLQRHL QATHPIHWAV ANKDSGAVAN GLDEAETERS DLLSDTLHGE
360 370 380 390 400
KSTGSQDLTA EDLSDSDSDE PMLEVENRSE SPIPVAEQGT LMRAQERETT
410 420 430 440 450
CCGNPVSSHI SQAIIQMIVE DMHPYNYFST PAFQRFMQIV APDYRLPSET
460 470 480 490 500
YFFTKAVPQL YDCVREKIFL TLENVQSQKI HLTVDIWTHD PSTDYFIVTV
510 520 530 540 550
HWVSLETASF LNNGRIPDFR KWAVLCVTGL AKDCLITNIL QELNDQIGLW
560 570 580 590 600
LSPNFLIPSF IVSDNSSNVV HAIKDGGFTH VPCFLHCLNM VIQDFFCEHK
610 620 630 640 650
SIENMLVAAR KTCHHFSHSV KARQILQEFQ NDHQLPWKNL KQDETGHWIS
660 670 680 690 700
TFYMLKWLLE HCYSVHHSLG RASGVVLTSL QWTLMTYVCD ILKPFEEATQ
710 720 730 740 750
KVSVKTAGLN QVLPLIHHLL LSLQKLREDF QVRGITQALN LVDSLSLKLE
760 770 780 790 800
TDTLLSAMLK SKPCILATLL DPCFKNSLED FFPQGADLET YKQFLAEEVC
810 820 830 840 850
NYMESSPEIC QIPTSEASCP SVTVGADSFT SSLKEGTSSS GSVDSSAVDN
860 870 880 890 900
VALGSKSFMF PSAVAVVDEY FKEKYSEFSG GDDPLIYWQR KISIWPALTQ
910 920 930 940 950
VAIQYLSCPM CSWQSECIFT KNSHFHPKQI MSLDFDNIEQ LMFLKMNLKN
960 970
VNYDYSTLVL SWDPEQNEVV QSSEKEILP
Length:979
Mass (Da):109,973
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48D5B5EE9AFDC2A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC114402 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55673.1

NCBI Reference Sequences

More...
RefSeqi
NP_001167579.1, NM_001174108.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000550078; ENSP00000447879; ENSG00000257315

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100381270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100381270

UCSC genome browser

More...
UCSCi
uc021phs.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114402 Genomic DNA No translation available.
CCDSiCCDS55673.1
RefSeqiNP_001167579.1, NM_001174108.2

3D structure databases

SMRiP86452
ModBaseiSearch...

Protein-protein interaction databases

BioGridi1147772, 5 interactors
IntActiP86452, 5 interactors
STRINGi9606.ENSP00000447879

PTM databases

iPTMnetiP86452
PhosphoSitePlusiP86452

Polymorphism and mutation databases

BioMutaiZBED6
DMDMi292495573

Proteomic databases

EPDiP86452
jPOSTiP86452
MassIVEiP86452
MaxQBiP86452
PaxDbiP86452
PeptideAtlasiP86452
PRIDEiP86452
ProteomicsDBi57774

Genome annotation databases

EnsembliENST00000550078; ENSP00000447879; ENSG00000257315
GeneIDi100381270
KEGGihsa:100381270
UCSCiuc021phs.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100381270
DisGeNETi100381270
EuPathDBiHostDB:ENSG00000257315.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZBED6
HGNCiHGNC:33273 ZBED6
HPAiHPA068807
MIMi613512 gene
neXtProtiNX_P86452
OpenTargetsiENSG00000257315
PharmGKBiPA165752811

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IR9U Eukaryota
ENOG410YAJD LUCA
GeneTreeiENSGT00940000163411
InParanoidiP86452
OMAiKTSAVWN
OrthoDBi223749at2759
PhylomeDBiP86452
TreeFamiTF322818

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZBED6
PharosiP86452 Tdark

Protein Ontology

More...
PROi
PR:P86452
RNActiP86452 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000257315 Expressed in 90 organ(s), highest expression level in intestine
GenevisibleiP86452 HS

Family and domain databases

InterProiView protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 2 hits
SMARTiView protein in SMART
SM00614 ZnF_BED, 2 hits
SUPFAMiSSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBED6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P86452
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: December 11, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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