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Protein

Helokinestatin-1

Gene
N/A
Organism
Heloderma horridum horridum (Mexican beaded lizard)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Helokinestatin antagonizes the vasodilatory actions of bradykinin at the B2 bradykinin receptor (BDKRB2) in a dose-dependent manner.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Helokinestatin-1
Alternative name(s):
Helokinestatin1 Publication
OrganismiHeloderma horridum horridum (Mexican beaded lizard)
Taxonomic identifieri8552 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaAnguimorphaNeoanguimorphaHelodermatidaeHeloderma

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003924511 – 10Helokinestatin-110

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Sequencei

Sequence statusi: Complete.

Length:10
Mass (Da):1,123
Last modified:March 23, 2010 - v1
Checksum:i3150E9C73776CB47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence uncertaintyi7L or I1 Publication1

Mass spectrometryi

Molecular mass is 1122.62 Da from positions 1 - 10. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiHKS_HELHO
AccessioniPrimary (citable) accession number: P86447
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 22, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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