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Protein

Conotoxin tx3e

Gene
N/A
Organism
Conus textile (Cloth-of-gold cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin tx3eCurated
Alternative name(s):
Conotoxin 4Curated
Cleaved into the following chain:
OrganismiConus textile (Cloth-of-gold cone)
Taxonomic identifieri6494 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusCylinder

Organism-specific databases

ConoServeri3749 Tx3e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003712771 – 17Conotoxin tx3eAdd BLAST17
PeptideiPRO_00004451212 – 17Truncated conotoxin tx3e1 PublicationAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 16By similarity
Disulfide bondi3 ↔ 12By similarity
Disulfide bondi8 ↔ 15By similarity
Modified residuei144-hydroxyproline; partial2 Publications1

Post-translational modificationi

Contains 3 disulfide bonds.1 Publication
The truncated conotoxin tx3e is only found with an hydroxyproline, whereas conotoxin tx3e is either hydroxylated or not hydroxylated.1 Publication

Keywords - PTMi

Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Domaini

The cysteine framework is III (CC-C-C-CC). Classified in the M-2 branch, since 2 residues stand between the fourth and the fifth cysteine residues.Curated

Sequence similaritiesi

Belongs to the conotoxin M superfamily.Curated

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Length:17
Mass (Da):1,835
Last modified:May 5, 2009 - v1
Checksum:i6A00F72EBAF71CA4
GO

Mass spectrometryi

Molecular mass is 1843.568±0.02 Da from positions 1 - 17. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri3749 Tx3e

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiM3E_CONTE
AccessioniPrimary (citable) accession number: P86262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 10, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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