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Protein

Elongation factor Tu, mitochondrial

Gene

TUFM

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 66GTPBy similarity5

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu, mitochondrialBy similarity
Short name:
EF-TuBy similarity
Gene namesi
Name:TUFMBy similarity
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000394413‹1 – ›174Elongation factor Tu, mitochondrialAdd BLAST›174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78N6-succinyllysineBy similarity1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei161N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP86251

Structurei

3D structure databases

SMRiP86251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit

Sequencei

Sequence statusi: Fragments.

P86251-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DKPHVNVGTI GHVDHGKILA EGGGAKKYEE IDNAPEERAR GITINAAHVE
60 70 80 90 100
YSTAARHYAH TDCPGHADYV KDPELGVKSV QKLLDAVDTY IPVPTRGTVV
110 120 130 140 150
TGTLERGDEC ELLGHNKNIR SLERAEAGDN LGALVRGLVM VKPGSIQPHQ
160 170
KVEAQVYILS KEEGGRFTLR DGNK
Length:174
Mass (Da):18,836
Last modified:June 15, 2010 - v1
Checksum:i213E3FD79039FE38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-adjacent residuesi17 – 18Curated2
Non-adjacent residuesi26 – 27Curated2
Non-adjacent residuesi71 – 72Curated2
Non-adjacent residuesi96 – 97Curated2
Non-adjacent residuesi106 – 107Curated2
Non-adjacent residuesi120 – 121Curated2
Non-adjacent residuesi136 – 137Curated2
Non-adjacent residuesi166 – 167Curated2
Non-terminal residuei1741

Cross-referencesi

3D structure databases

SMRiP86251
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP86251

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEFTU_MESAU
AccessioniPrimary (citable) accession number: P86251
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 22, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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