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Protein

Actin-like protein 6B

Gene

Actl6b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.By similarity

GO - Biological processi

  • chromatin remodeling Source: Ensembl
  • spinal cord development Source: RGD

Keywordsi

Molecular functionChromatin regulator
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-3214858 RMTs methylate histone arginines
R-RNO-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 6BBy similarity
Alternative name(s):
BRG1-associated factor 53B
Short name:
BAF53B
Gene namesi
Name:Actl6bBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1307763 Actl6b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003654781 – 426Actin-like protein 6BAdd BLAST426

Proteomic databases

PaxDbiP86173
PRIDEiP86173

PTM databases

iPTMnetiP86173
PhosphoSitePlusiP86173

Expressioni

Tissue specificityi

Expressed in hippocampus, exclusively in neurons, but not in glial cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000001408 Expressed in 3 organ(s), highest expression level in brain
ExpressionAtlasiP86173 baseline and differential
GenevisibleiP86173 RN

Interactioni

Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (By similarity).Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A or SMARCD2/BAF60B or SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (ACTB). Note that the nBAF complex is polymorphic in regard to the ATPase, SMARCA2 and SMARCA4 occupying mutually exclusive positions (By similarity). May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001910

Structurei

3D structure databases

ProteinModelPortaliP86173
SMRiP86173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 82Essential for mediating its function in dendritic development; may contribute to neuronal-specific targetingBy similarityAdd BLAST44

Sequence similaritiesi

Belongs to the actin family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0679 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00900000140992
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP86173
KOiK11652
OMAiQLWISKQ
OrthoDBiEOG091G0A1S
PhylomeDBiP86173
TreeFamiTF312863

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P86173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGVYGGDE VGALVFDIGS FSVRAGYAGE DCPKADFPTT VGLLAAEEGG
60 70 80 90 100
GLELEGEKEK KGKIFHIDTN ALHVPRDGAE VMSPLKNGMI EDWECFRAIL
110 120 130 140 150
DHTYSKHVKS EPNLHPVLMS EAPWNTRAKR EKLTELMFEQ YNIPAFFLCK
160 170 180 190 200
TAVLTAFANG RSTGLVLDSG ATHTTAIPVH DGYVLQQGIV KSPLAGDFIS
210 220 230 240 250
MQCRELFQEM AIDIIPPYMI AAKEPVREGA PPNWKKKEKL PQVSKSWHNY
260 270 280 290 300
MCNEVIQDFQ ASVLQVSDSP YDEQVAAQMP TVHYEMPNGY NTDYGAERLR
310 320 330 340 350
IPEGLFDPSN VKGLSGNTML GVGHVVTTSI GMCDIDIRPG LYGSVIVTGG
360 370 380 390 400
NTLLQGFTDR LNRELSQKTP PSMRLKLIAS NSTMERKFSP WIGGSILASL
410 420
GTFQQMWISK QEYEEGGKQC VERKCP
Length:426
Mass (Da):46,891
Last modified:October 13, 2009 - v2
Checksum:i7B9CD9B70E1304CE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JW70A0A0G2JW70_RAT
Actin-like protein 6B
Actl6b
345Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473973 Genomic DNA Translation: EDM13260.1
RefSeqiNP_001099387.2, NM_001105917.1
UniGeneiRn.44972

Genome annotation databases

EnsembliENSRNOT00000001910; ENSRNOP00000001910; ENSRNOG00000001408
GeneIDi288563
KEGGirno:288563
UCSCiRGD:1307763 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473973 Genomic DNA Translation: EDM13260.1
RefSeqiNP_001099387.2, NM_001105917.1
UniGeneiRn.44972

3D structure databases

ProteinModelPortaliP86173
SMRiP86173
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001910

PTM databases

iPTMnetiP86173
PhosphoSitePlusiP86173

Proteomic databases

PaxDbiP86173
PRIDEiP86173

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001910; ENSRNOP00000001910; ENSRNOG00000001408
GeneIDi288563
KEGGirno:288563
UCSCiRGD:1307763 rat

Organism-specific databases

CTDi51412
RGDi1307763 Actl6b

Phylogenomic databases

eggNOGiKOG0679 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00900000140992
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP86173
KOiK11652
OMAiQLWISKQ
OrthoDBiEOG091G0A1S
PhylomeDBiP86173
TreeFamiTF312863

Enzyme and pathway databases

ReactomeiR-RNO-3214858 RMTs methylate histone arginines
R-RNO-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

PROiPR:P86173

Gene expression databases

BgeeiENSRNOG00000001408 Expressed in 3 organ(s), highest expression level in brain
ExpressionAtlasiP86173 baseline and differential
GenevisibleiP86173 RN

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACL6B_RAT
AccessioniPrimary (citable) accession number: P86173
Secondary accession number(s): A6J021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 13, 2009
Last modified: November 7, 2018
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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