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UniProtKB - P85971 (6PGL_RAT)
Protein
6-phosphogluconolactonase
Gene
Pgls
Organism
Rattus norvegicus (Rat)
Status
Functioni
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
By similarityCatalytic activityi
- EC:3.1.1.31By similarity
: pentose phosphate pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).By similarity This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
GO - Molecular functioni
- 6-phosphogluconolactonase activity Source: RGD
- monosaccharide binding Source: RGD
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- pentose-phosphate shunt Source: RGD
- pentose-phosphate shunt, oxidative branch Source: RGD
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
Reactomei | R-RNO-71336, Pentose phosphate pathway |
UniPathwayi | UPA00115;UER00409 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PglsBy similarity |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1307001, Pgls |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000349118 | 2 – 257 | 6-phosphogluconolactonaseAdd BLAST | 256 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 49 | PhosphoserineCombined sources | 1 | |
Modified residuei | 180 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P85971 |
PaxDbi | P85971 |
PRIDEi | P85971 |
2D gel databases
World-2DPAGEi | 0004:P85971 |
PTM databases
iPTMneti | P85971 |
PhosphoSitePlusi | P85971 |
SwissPalmi | P85971 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.Sequence analysis
Phylogenomic databases
eggNOGi | KOG3147, Eukaryota |
InParanoidi | P85971 |
OMAi | YQLFEFE |
PhylomeDBi | P85971 |
Family and domain databases
CDDi | cd01400, 6PGL, 1 hit |
InterProi | View protein in InterPro IPR005900, 6-phosphogluconolactonase_DevB IPR006148, Glc/Gal-6P_isomerase IPR037171, NagB/RpiA_transferase-like IPR039104, PGLS |
PANTHERi | PTHR11054, PTHR11054, 1 hit |
Pfami | View protein in Pfam PF01182, Glucosamine_iso, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR01198, pgl, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P85971-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPAPGLIS VFSSPQELGA SLAQLVAQRA ASCLEGNRGR FALGLSGGSL
60 70 80 90 100
VSMLARDLPA ATAPAGPASF ARWTLGFCDE RLVPFDHAES TYGLYRTHLL
110 120 130 140 150
SKLPIPDSQV LTIDPALPVE DAAEDYARKL RQAFQGDTVP VFDLLILGVG
160 170 180 190 200
PDGHTCSLFP GHPLLQEREK IVAPIGDSPK PPPQRVTLTL PVLNAAQSVI
210 220 230 240 250
FVATGEGKAA VLKRILEDQE SALPAAMVQP RTGALCWFLD EAAARLLSVP
FEKHSTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V8D5 | G3V8D5_RAT | 6-phosphogluconolactonase | Pgls Pgls_predicted, rCG_38716 | 291 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03100626 Genomic DNA No translation available. |
Genome annotation databases
UCSCi | RGD:1307001, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03100626 Genomic DNA No translation available. |
3D structure databases
SMRi | P85971 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024827 |
PTM databases
iPTMneti | P85971 |
PhosphoSitePlusi | P85971 |
SwissPalmi | P85971 |
2D gel databases
World-2DPAGEi | 0004:P85971 |
Proteomic databases
jPOSTi | P85971 |
PaxDbi | P85971 |
PRIDEi | P85971 |
Genome annotation databases
UCSCi | RGD:1307001, rat |
Organism-specific databases
RGDi | 1307001, Pgls |
Phylogenomic databases
eggNOGi | KOG3147, Eukaryota |
InParanoidi | P85971 |
OMAi | YQLFEFE |
PhylomeDBi | P85971 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00409 |
Reactomei | R-RNO-71336, Pentose phosphate pathway |
Miscellaneous databases
PROi | PR:P85971 |
Family and domain databases
CDDi | cd01400, 6PGL, 1 hit |
InterProi | View protein in InterPro IPR005900, 6-phosphogluconolactonase_DevB IPR006148, Glc/Gal-6P_isomerase IPR037171, NagB/RpiA_transferase-like IPR039104, PGLS |
PANTHERi | PTHR11054, PTHR11054, 1 hit |
Pfami | View protein in Pfam PF01182, Glucosamine_iso, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR01198, pgl, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 6PGL_RAT | |
Accessioni | P85971Primary (citable) accession number: P85971 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | April 7, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families