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UniProtKB - P85968 (6PGD_RAT)
Protein
6-phosphogluconate dehydrogenase, decarboxylating
Gene
Pgd
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
By similarityCatalytic activityi
- EC:1.1.1.44By similarity
: pentose phosphate pathway Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).By similarity This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 103 | NADPBy similarity | 1 | |
Binding sitei | 103 | SubstrateBy similarity | 1 | |
Active sitei | 184 | Proton acceptorBy similarity | 1 | |
Active sitei | 191 | Proton donorBy similarity | 1 | |
Binding sitei | 192 | SubstrateBy similarity | 1 | |
Binding sitei | 261 | Substrate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 288 | SubstrateBy similarity | 1 | |
Binding sitei | 447 | Substrate; shared with dimeric partnerBy similarity | 1 | |
Binding sitei | 453 | Substrate; shared with dimeric partnerBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 15 | NADPBy similarity | 6 | |
Nucleotide bindingi | 33 – 35 | NADPBy similarity | 3 | |
Nucleotide bindingi | 75 – 77 | NADPBy similarity | 3 | |
Nucleotide bindingi | 478 – 481 | NADP; shared with dimeric partnerBy similarity | 4 |
GO - Molecular functioni
- carbohydrate binding Source: RGD
- carboxylic acid binding Source: RGD
- NADP binding Source: RGD
- phosphogluconate dehydrogenase (decarboxylating) activity Source: RGD
GO - Biological processi
- carbohydrate metabolic process Source: RGD
- D-gluconate catabolic process Source: GO_Central
- D-gluconate metabolic process Source: RGD
- NADP metabolic process Source: RGD
- pentose biosynthetic process Source: RGD
- pentose-phosphate shunt Source: RGD
- pentose-phosphate shunt, oxidative branch Source: RGD
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Gluconate utilization, Pentose shunt |
Ligand | NADP |
Enzyme and pathway databases
SABIO-RKi | P85968 |
UniPathwayi | UPA00115;UER00410 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PgdBy similarity |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1583832, Pgd |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: GO_Central
Other locations
- intracellular membrane-bounded organelle Source: RGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349115 | 1 – 483 | 6-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST | 483 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 57 | PhosphoserineBy similarity | 1 | |
Modified residuei | 59 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 129 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P85968 |
2D gel databases
World-2DPAGEi | 0004:P85968 |
PTM databases
iPTMneti | P85968 |
PhosphoSitePlusi | P85968 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
IntActi | P85968, 2 interactors |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 131 | Substrate bindingBy similarity | 3 | |
Regioni | 187 – 188 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the 6-phosphogluconate dehydrogenase family.Sequence analysis
Phylogenomic databases
InParanoidi | P85968 |
OrthoDBi | 847823at2759 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006114, 6PGDH_C IPR006113, 6PGDH_Gnd/GntZ IPR006115, 6PGDH_NADP-bd IPR006184, 6PGdom_BS IPR036291, NAD(P)-bd_dom_sf IPR006183, Pgluconate_DH |
PANTHERi | PTHR11811, PTHR11811, 1 hit |
Pfami | View protein in Pfam PF00393, 6PGD, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000109, 6PGD, 1 hit |
PRINTSi | PR00076, 6PGDHDRGNASE |
SMARTi | View protein in SMART SM01350, 6PGD, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00873, gnd, 1 hit |
PROSITEi | View protein in PROSITE PS00461, 6PGD, 1 hit |
i Sequence
Sequence statusi: Complete.
P85968-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLAKEAKGT
60 70 80 90 100
KVIGAKSLKD MVSKLKKPRR VILLVKAGQA VDDFIEKLVP LLDTGDIIID
110 120 130 140 150
GGNSEYRDTT RRCQDLKAKG ILFVGSGVSG GEEGARYGPS LMPGGNKEAW
160 170 180 190 200
PHIKTIFQAI AAKVGTGEPC CDWVGDEGAG HFVKMVHNGI EYGDMQLICE
210 220 230 240 250
AYHLMKDVLG MRHEEMAQAF EDWNKTELDS FLIEITANIL KFQDTDGKEL
260 270 280 290 300
LPKIRDSAGQ KGTGKWTAIS ALEYGMPVTL IGEAVFARCL SSLKEERVQA
310 320 330 340 350
SRKLKGPKMV QLEGSKQAFL EDVRKALYAS KIISYAQGFM LLRQAATEFG
360 370 380 390 400
WTLNYGGIAL MWRGGCIIRS VFLGKIKDAF ERNPELQNLL LDDFFKSAVD
410 420 430 440 450
DCQDSWRRVI STGVQAGIPM PCFTTALSFY DGYRHEMLPA NLIQAQRDYF
460 470 480
GAHTYELLSK PGEFIHTNWT GHGGSVSSSS YNA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03040409 Genomic DNA No translation available. |
RefSeqi | NP_001292364.1, NM_001305435.1 |
Genome annotation databases
Ensembli | ENSRNOT00000104782; ENSRNOP00000082532; ENSRNOG00000057626 |
GeneIDi | 100360180 |
KEGGi | rno:100360180 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03040409 Genomic DNA No translation available. |
RefSeqi | NP_001292364.1, NM_001305435.1 |
3D structure databases
AlphaFoldDBi | P85968 |
SMRi | P85968 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P85968, 2 interactors |
PTM databases
iPTMneti | P85968 |
PhosphoSitePlusi | P85968 |
2D gel databases
World-2DPAGEi | 0004:P85968 |
Proteomic databases
jPOSTi | P85968 |
Genome annotation databases
Ensembli | ENSRNOT00000104782; ENSRNOP00000082532; ENSRNOG00000057626 |
GeneIDi | 100360180 |
KEGGi | rno:100360180 |
Organism-specific databases
CTDi | 5226 |
RGDi | 1583832, Pgd |
Phylogenomic databases
InParanoidi | P85968 |
OrthoDBi | 847823at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00410 |
SABIO-RKi | P85968 |
Miscellaneous databases
PROi | PR:P85968 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006114, 6PGDH_C IPR006113, 6PGDH_Gnd/GntZ IPR006115, 6PGDH_NADP-bd IPR006184, 6PGdom_BS IPR036291, NAD(P)-bd_dom_sf IPR006183, Pgluconate_DH |
PANTHERi | PTHR11811, PTHR11811, 1 hit |
Pfami | View protein in Pfam PF00393, 6PGD, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000109, 6PGD, 1 hit |
PRINTSi | PR00076, 6PGDHDRGNASE |
SMARTi | View protein in SMART SM01350, 6PGD, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00873, gnd, 1 hit |
PROSITEi | View protein in PROSITE PS00461, 6PGD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 6PGD_RAT | |
Accessioni | P85968Primary (citable) accession number: P85968 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families