UniProtKB - P85876 (ETCM_ENTFC)
Protein
Bacteriocin enterocin-M
Gene
N/A
Organism
Enterococcus faecium (Streptococcus faecium)
Status
Functioni
Bacteriocin that inhibits the growth of closely related Enterococcus species and a wide range of Gram-positive bacterial species. Inhibits the growth of several strains of the Gram-negative bacterium E.coli, but not the growth of Gram-negative Pseudomonas species.1 Publication
pH dependencei
Stable at pH 5.0.1 Publication
Temperature dependencei
Thermostable, retains activity after heating at 60, 80 and 100 degrees Celsius for 1 hour. Long-term storage at 4 degrees Celsius or -20 degrees Celsius does not affect activity.1 Publication
GO - Biological processi
- cytolysis Source: UniProtKB-KW
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Bacteriocin |
Names & Taxonomyi
Protein namesi | Recommended name: Bacteriocin enterocin-M |
Organismi | Enterococcus faecium (Streptococcus faecium) |
Taxonomic identifieri | 1352 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Enterococcaceae › Enterococcus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371799 | 1 – ›38 | Bacteriocin enterocin-MAdd BLAST | ›38 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 11 ↔ 16 | By similarity |
Keywords - PTMi
Disulfide bondFamily & Domainsi
Sequence similaritiesi
Belongs to the bacteriocin class IIA/YGNGV family.Sequence analysis
Family and domain databases
InterProi | View protein in InterPro IPR002633, Bacteriocin_IIa IPR023384, Bacteriocin_IIa_CS |
Pfami | View protein in Pfam PF01721, Bacteriocin_II, 1 hit |
PROSITEi | View protein in PROSITE PS60030, BACTERIOCIN_IIA, 1 hit |
i Sequence
Sequence statusi: Fragment.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 38 | 1 Publication | 1 |
Mass spectrometryi
Molecular mass is 4637.99 Da. Determined by MALDI. 1 Publication
Cross-referencesi
3D structure databases
SMRi | P85876 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR002633, Bacteriocin_IIa IPR023384, Bacteriocin_IIa_CS |
Pfami | View protein in Pfam PF01721, Bacteriocin_II, 1 hit |
PROSITEi | View protein in PROSITE PS60030, BACTERIOCIN_IIA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ETCM_ENTFC | |
Accessioni | P85876Primary (citable) accession number: P85876 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 11, 2019 | |
This is version 15 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families