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Protein

Ferritin, heavy subunit

Gene
N/A
Organism
Trematomus newnesi (Dusky notothen)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi59Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi59Iron 2PROSITE-ProRule annotationBy similarity1
Metal bindingi62Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi104Iron 2PROSITE-ProRule annotationBy similarity1
Metal bindingi138Iron 2PROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, heavy subunit1 Publication (EC:1.16.3.1)
Short name:
Ferritin H1 Publication
OrganismiTrematomus newnesi (Dusky notothen)
Taxonomic identifieri35730 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeTrematomus

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003527811 – 174Ferritin, heavy subunitAdd BLAST174

Proteomic databases

PRIDEiP85837

Expressioni

Tissue specificityi

Liver (at protein level).1 Publication

Interactioni

Subunit structurei

In liver, forms a heteropolymer consisting of middle and heavy subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.Curated1 Publication

Structurei

3D structure databases

SMRiP85837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Sequence analysis

Phylogenomic databases

HOVERGENiHBG000410

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P85837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQVRQNFH KDCEAAINRQ INLELYASYS YLSMAYYFDR DDVALPGFAH
60 70 80 90 100
FFKHQSEEER EHAEKLMKQQ NQRGGRIFLQ DVKKPDRDEW GSGLDALECA
110 120 130 140 150
LQLEKNVNQS LLDLHKVCSE HNDPHMCDFL ETHYLDEQVK SIKELGDWVT
160 170
NLRRLGAPQN GMAEYLFDKH TLGK
Length:174
Mass (Da):20,379
Last modified:October 14, 2008 - v1
Checksum:i2A0C1B99353515E6
GO

Similar proteinsi

Entry informationi

Entry nameiFRIH_TRENE
AccessioniPrimary (citable) accession number: P85837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: May 23, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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