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Protein

Ferritin, middle subunit

Gene
N/A
Organism
Trematomus newnesi (Dusky notothen)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.1 Publication

Temperature dependencei

Thermostable.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi59Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi59Iron 2PROSITE-ProRule annotationBy similarity1
Metal bindingi62Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi104Iron 2PROSITE-ProRule annotationBy similarity1
Metal bindingi138Iron 2PROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, middle subunit1 Publication (EC:1.16.3.1)
Short name:
Ferritin M1 Publication
OrganismiTrematomus newnesi (Dusky notothen)
Taxonomic identifieri35730 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeTrematomus

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003527831 – 176Ferritin, middle subunitAdd BLAST176

Expressioni

Tissue specificityi

Liver and spleen (at protein level).1 Publication

Interactioni

Subunit structurei

In liver, forms a heteropolymer consisting of middle and heavy subunits. In spleen, forms a homopolymer. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.Curated1 Publication

Structurei

3D structure databases

SMRiP85835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Sequence analysis

Phylogenomic databases

HOVERGENiHBG000410

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P85835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQVRQNYH RDCEAAVNRM INMELFASYS YTSMAFYFSR DDVALPGFAH
60 70 80 90 100
FFKENSEEER EHADKLLTFQ NSRGGRIFLQ DIKKPERDEW GSGLDALQSS
110 120 130 140 150
LQLEKNVNQA LLDLHKIASD HTDPHMCDFL ETHYLNEQVE SIKKLGDFIT
160 170
NLSRMDAVKN KMAEYLFDKH TMGGKN
Length:176
Mass (Da):20,450
Last modified:October 14, 2008 - v1
Checksum:i161929EF2565AC4B
GO

Similar proteinsi

Entry informationi

Entry nameiFRIM_TRENE
AccessioniPrimary (citable) accession number: P85835
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: November 22, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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