UniProtKB - P85814 (TPIS_PLAOI)
Protein
Triosephosphate isomerase
Gene
N/A
Organism
Platanus orientalis (Oriental plane-tree)
Status
Functioni
Catalytic activityi
- EC:5.3.1.1PROSITE-ProRule annotationBy similarity
: gluconeogenesis Pathwayi
This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.PROSITE-ProRule annotationBy similarityView all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.
Pathwayi: glycolysis
This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.PROSITE-ProRule annotationBy similarityProteins known to be involved in this subpathway in this organism are:
- Triosephosphate isomerase
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 62 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
GO - Molecular functioni
- triose-phosphate isomerase activity Source: UniProtKB-EC
GO - Biological processi
- gluconeogenesis Source: UniProtKB-UniPathway
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Gluconeogenesis, Glycolysis |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00189 UPA00138 |
Names & Taxonomyi
Protein namesi | Recommended name: Triosephosphate isomerase (EC:5.3.1.1)Short name: TIM Alternative name(s): Triose-phosphate isomerase Allergen: Pla o 4 |
Organismi | Platanus orientalis (Oriental plane-tree) |
Taxonomic identifieri | 122832 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Proteales › Platanaceae › Platanus |
Pathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.1 Publication
Keywords - Diseasei
AllergenPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000343452 | ‹1 – ›86 | Triosephosphate isomeraseAdd BLAST | ›86 |
Interactioni
Subunit structurei
Homodimer.
PROSITE-ProRule annotationBy similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the triosephosphate isomerase family.PROSITE-ProRule annotation
Family and domain databases
Gene3Di | 3.20.20.70, 2 hits |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR035990, TIM_sf IPR000652, Triosephosphate_isomerase IPR020861, Triosephosphate_isomerase_AS |
PANTHERi | PTHR21139, PTHR21139, 2 hits |
Pfami | View protein in Pfam PF00121, TIM, 1 hit |
SUPFAMi | SSF51351, SSF51351, 1 hit |
PROSITEi | View protein in PROSITE PS00171, TIM_1, 1 hit PS51440, TIM_2, 1 hit |
i Sequence
Sequence statusi: Fragments.
P85814-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAATSLTAPP SFSGLRASRA VVAMAGTGKG GAFTGEISVE QLKDIGRWVI
60 70 80
LGHSERIVVA YEPVWAIGTG KVATPDQAQE VHGLCR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 Publication | 1 | |
Non-adjacent residuesi | 16 – 17 | 1 Publication | 2 | |
Non-adjacent residuesi | 29 – 30 | 1 Publication | 2 | |
Non-adjacent residuesi | 47 – 48 | 1 Publication | 2 | |
Non-adjacent residuesi | 56 – 57 | 1 Publication | 2 | |
Non-terminal residuei | 86 | 1 Publication | 1 |
Mass spectrometryi
Molecular mass is 27074.8 Da. Determined by MALDI. 1 Publication
Cross-referencesi
3D structure databases
SMRi | P85814 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00189 UPA00138 |
Family and domain databases
Gene3Di | 3.20.20.70, 2 hits |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR035990, TIM_sf IPR000652, Triosephosphate_isomerase IPR020861, Triosephosphate_isomerase_AS |
PANTHERi | PTHR21139, PTHR21139, 2 hits |
Pfami | View protein in Pfam PF00121, TIM, 1 hit |
SUPFAMi | SSF51351, SSF51351, 1 hit |
PROSITEi | View protein in PROSITE PS00171, TIM_1, 1 hit PS51440, TIM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPIS_PLAOI | |
Accessioni | P85814Primary (citable) accession number: P85814 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Allergens
Nomenclature of allergens and list of entries