Triosephosphate isomerase

Functionⁱ

Catalytic activityⁱ

D-glyceraldehyde 3-phosphate = glycerone phosphate.PROSITE-ProRule annotationBy similarity

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.PROSITE-ProRule annotationBy similarity
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayⁱ: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.PROSITE-ProRule annotationBy similarity
Proteins known to be involved in this subpathway in this organism are:

Triosephosphate isomerase

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	62	Proton acceptorPROSITE-ProRule annotationBy similarity		1

GO - Molecular functionⁱ

triose-phosphate isomerase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-UniPathway
glycolytic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayⁱ	UPA00109;UER00189 UPA00138

UniPathwayⁱ

UPA00109;UER00189

UPA00138

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Triosephosphate isomerase (EC:5.3.1.1) Short name: TIM Alternative name(s): Triose-phosphate isomerase Allergen: Pla o 4
Organismⁱ	Platanus orientalis (Oriental plane-tree)
Taxonomic identifierⁱ	122832 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › early-diverging eudicotyledons › Proteales › Platanaceae › Platanus

Pathology & Biotechⁱ

Allergenic propertiesⁱ

Causes an allergic reaction in human.1 Publication

Keywords - Diseaseⁱ

Allergen

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000343452	‹1 – ›86	Triosephosphate isomeraseAdd BLAST		›86

Proteomic databases

PRIDEⁱ	P85814

PRIDEⁱ

P85814

Interactionⁱ

Subunit structureⁱ

Homodimer.PROSITE-ProRule annotationBy similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P85814
SMRⁱ	P85814
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the triosephosphate isomerase family.PROSITE-ProRule annotation

Family and domain databases

Gene3Dⁱ	3.20.20.70, 2 hits
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR035990 TIM_sf IPR000652 Triosephosphate_isomerase IPR020861 Triosephosphate_isomerase_AS
PANTHERⁱ	PTHR21139 PTHR21139, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00121 TIM, 1 hit
SUPFAMⁱ	SSF51351 SSF51351, 1 hit
PROSITEⁱ	View protein in PROSITE PS00171 TIM_1, 1 hit PS51440 TIM_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragments.

P85814-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAATSLTAPP SFSGLRASRA VVAMAGTGKG GAFTGEISVE QLKDIGRWVI 
        60         70         80 
LGHSERIVVA YEPVWAIGTG KVATPDQAQE VHGLCR

Length:86

Mass (Da):8,935

Last modified:July 1, 2008 - v1

Checksum:ⁱD816B8C38C23ACA1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Non-terminal residueⁱ	1	1 Publication	1
Non-adjacent residuesⁱ	16 – 17	1 Publication	2
Non-adjacent residuesⁱ	29 – 30	1 Publication	2
Non-adjacent residuesⁱ	47 – 48	1 Publication	2
Non-adjacent residuesⁱ	56 – 57	1 Publication	2
Non-terminal residueⁱ	86	1 Publication	1

Mass spectrometryⁱ

Molecular mass is 27074.8 Da . Determined by MALDI. 1 Publication

Entry informationⁱ

Entry nameⁱ	TPIS_PLAOI
Accessionⁱ	P85814Primary (citable) accession number: P85814
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
	Last sequence update:	July 1, 2008
	Last modified:	April 25, 2018
	This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing

UniProtKB - P85814 (TPIS_PLAOI)

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Allergenic propertiesⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Molecule processing

Proteomic databases

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Experimental Info

Mass spectrometryⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P85814 (TPIS_PLAOI)

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Triosephosphate isomerase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Mass spectrometryⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ