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Entry version 67 (12 Aug 2020)
Sequence version 2 (22 Sep 2009)
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Protein

Scavenger receptor cysteine-rich type 1 protein M130

Gene

CD163

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).By similarity
After shedding, the soluble form (sCD163) may play an anti-inflammatory role.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAcute phase, Inflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-2168880, Scavenging of heme from plasma

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Scavenger receptor cysteine-rich type 1 protein M130By similarity
Alternative name(s):
CD_antigen: CD163By similarity
Cleaved into the following chain:
Soluble CD163By similarity
Short name:
sCD163By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD163By similarity
Synonyms:M130By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini41 – 1039ExtracellularSequence analysisAdd BLAST999
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1040 – 1060HelicalSequence analysisAdd BLAST21
Topological domaini1061 – 1129CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Sequence analysisAdd BLAST40
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000037685241 – 1129Scavenger receptor cysteine-rich type 1 protein M130By similarityAdd BLAST1089
ChainiPRO_000037685341 – ?Soluble CD163By similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi71 ↔ 135PROSITE-ProRule annotation
Disulfide bondi84 ↔ 145PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi115 ↔ 125PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 242PROSITE-ProRule annotation
Disulfide bondi191 ↔ 252PROSITE-ProRule annotation
Disulfide bondi222 ↔ 232PROSITE-ProRule annotation
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi285 ↔ 349PROSITE-ProRule annotation
Disulfide bondi298 ↔ 359PROSITE-ProRule annotation
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 339PROSITE-ProRule annotation
Disulfide bondi392 ↔ 456PROSITE-ProRule annotation
Disulfide bondi405 ↔ 466PROSITE-ProRule annotation
Disulfide bondi436 ↔ 446PROSITE-ProRule annotation
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi497 ↔ 561PROSITE-ProRule annotation
Disulfide bondi510 ↔ 571PROSITE-ProRule annotation
Disulfide bondi541 ↔ 551PROSITE-ProRule annotation
Glycosylationi544N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi602 ↔ 666PROSITE-ProRule annotation
Disulfide bondi615 ↔ 676PROSITE-ProRule annotation
Disulfide bondi646 ↔ 656PROSITE-ProRule annotation
Glycosylationi679N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi738 ↔ 802PROSITE-ProRule annotation
Disulfide bondi751 ↔ 812PROSITE-ProRule annotation
Glycosylationi761N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi782 ↔ 792PROSITE-ProRule annotation
Disulfide bondi858 ↔ 919PROSITE-ProRule annotation
Disulfide bondi889 ↔ 899PROSITE-ProRule annotation
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi948 ↔ 1012PROSITE-ProRule annotation
Disulfide bondi961 ↔ 1022PROSITE-ProRule annotation
Disulfide bondi992 ↔ 1002PROSITE-ProRule annotation
Glycosylationi995N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs (By similarity).By similarity
Phosphorylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei263 – 264Cleavage; in calcium-free conditionBy similarity2
Sitei275 – 276Cleavage; in calcium-free conditionBy similarity2
Sitei327 – 328Cleavage; in calcium-free conditionBy similarity2
Sitei354 – 355Cleavage; in calcium-free conditionBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P85521

PRoteomics IDEntifications database

More...
PRIDEi
P85521

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000019669, Expressed in lung and 16 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P85521, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CSNK2B.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000026215

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P85521

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 146SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini153 – 253SRCR 2PROSITE-ProRule annotationAdd BLAST101
Domaini260 – 360SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini367 – 467SRCR 4PROSITE-ProRule annotationAdd BLAST101
Domaini472 – 572SRCR 5PROSITE-ProRule annotationAdd BLAST101
Domaini577 – 677SRCR 6PROSITE-ProRule annotationAdd BLAST101
Domaini713 – 813SRCR 7PROSITE-ProRule annotationAdd BLAST101
Domaini818 – 920SRCR 8PROSITE-ProRule annotationAdd BLAST103
Domaini923 – 1023SRCR 9PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1085 – 1088Internalization signalBy similarity4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ5W, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_258459_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P85521

KEGG Orthology (KO)

More...
KOi
K06545

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGQVWRH

Database of Orthologous Groups

More...
OrthoDBi
1095487at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329295

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.250.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00530, SRCR, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258, SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00202, SR, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56487, SSF56487, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00420, SRCR_1, 5 hits
PS50287, SRCR_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P85521-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLHDNSGSA GFKRCSVHFG PFTLAVVSVL YACLITSALG GTDKELRLVA
60 70 80 90 100
GQTKCSGRVE VKVQEEWGTV CNTGWDLAAV SVVCKQLGCP SVIKATGWTN
110 120 130 140 150
SSAGTGRIWM DHVSCRGNES ALWDCKHEGW GKHNCTHQQD VGVTCSDGSD
160 170 180 190 200
LEMRLMNGGN RCSGRIEIKF QGQWGTVCDD NFNLDHASVV CKQLGCGSAV
210 220 230 240 250
SFSGSANFGE GSGPIWFDDL VCHGNESALW NCRHEGWGKH NCDHAEDAGV
260 270 280 290 300
ICLEGADLSL RLVDGVTKCS GRLEVRFQGE WGTVCDDGWD SDDAAVACQQ
310 320 330 340 350
LGCPTAITAV GRVNASEGTG HIWLDSVSCQ GHESAVWQCR HHEWGKHYCN
360 370 380 390 400
HNEDAGVTCS DGSDLELRLK GGGSRCAGTV EVEIQKLIGK VCDRSWGLKE
410 420 430 440 450
ADVVCKQLGC GSALRTSYQV YSKIQATNTW LFLNNCNGNE TSIWDCKNWQ
460 470 480 490 500
WGGLSCEHYH EAKVTCSAHR EPRLVGGDIP CSGRVEVKHG DTWGTICDSD
510 520 530 540 550
FSLESASVLC RELECGSVVS ILGGAHFGEG NGQIWAEEFQ CEGNESHLSL
560 570 580 590 600
CPVAPRLDGT CSHSKDIGVV CSRYTEVRLV GGNTPCEGRV EVKILGTWGP
610 620 630 640 650
LCNSHWDMED AHVLCQQLKC GVAASIPGRA PFGKGSGQPW RHMFHCTGTE
660 670 680 690 700
QHMGDCPVTA LGASLCPEGQ VASVICSGNR SQTLYPCNSS SSDPESSVVL
710 720 730 740 750
EENGVPCIGS GQLRLVNGGG RCAGRIEVYH EGSWGTICDD SWDLDDAHVV
760 770 780 790 800
CRQLGCGVAI NATGSAHFGE GSGPIWLDEV NCNGKEPRIS QCRSHGWGRQ
810 820 830 840 850
NCRHKEDAGV ICSEFMSLRL ISDSSSETCA GRLEVFYNGA WGSVGKSDMS
860 870 880 890 900
ATTVGVVCRQ LGCTDKGSIR PAPSDKVENR YMWVDNVRCP KGPETLWQCP
910 920 930 940 950
SSPWKRRLAS PSEETWITCA DKIRLQEGTT NCSGRVEVWH GGSWGTVCDD
960 970 980 990 1000
SWDLNDAQVV CRQLGCGLAL EAGKEAAFGQ GTGPIWLNEV KCKGNESSLW
1010 1020 1030 1040 1050
DCPARSWGHS DCGHKEDASV KCSEIAESKG SVKAAGHSST VALGILGVIL
1060 1070 1080 1090 1100
LAFLIATLLW IQRRRQRQRL AVSSRGENSV HEIQYREMNS CLKADDLDLY
1110 1120
NSSGLWVLRG SIALGFRLVT AAEAERHST
Length:1,129
Mass (Da):121,806
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2479FF57C3DC21BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1LQ59A0A3Q1LQ59_BOVIN
Scavenger receptor cysteine-rich ty...
CD163
1,127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4 – 6HDN → LED in ACS87934 (Ref. 1) Curated3
Sequence conflicti35I → V in ACS87934 (Ref. 1) Curated1
Sequence conflicti957A → T in ACS87934 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GQ184570 mRNA Translation: ACS87934.1
AAFC03037181 Genomic DNA No translation available.
AAFC03037182 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001156885.1, NM_001163413.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000026215; ENSBTAP00000026215; ENSBTAG00000019669

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
533844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:533844

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ184570 mRNA Translation: ACS87934.1
AAFC03037181 Genomic DNA No translation available.
AAFC03037182 Genomic DNA No translation available.
RefSeqiNP_001156885.1, NM_001163413.1

3D structure databases

SMRiP85521
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026215

Proteomic databases

PaxDbiP85521
PRIDEiP85521

Genome annotation databases

EnsembliENSBTAT00000026215; ENSBTAP00000026215; ENSBTAG00000019669
GeneIDi533844
KEGGibta:533844

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9332

Phylogenomic databases

eggNOGiENOG502QQ5W, Eukaryota
GeneTreeiENSGT00940000155987
HOGENOMiCLU_258459_0_0_1
InParanoidiP85521
KOiK06545
OMAiSGQVWRH
OrthoDBi1095487at2759
TreeFamiTF329295

Enzyme and pathway databases

ReactomeiR-BTA-2168880, Scavenging of heme from plasma

Gene expression databases

BgeeiENSBTAG00000019669, Expressed in lung and 16 other tissues
ExpressionAtlasiP85521, baseline

Family and domain databases

Gene3Di3.10.250.10, 9 hits
InterProiView protein in InterPro
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
PfamiView protein in Pfam
PF00530, SRCR, 9 hits
PRINTSiPR00258, SPERACTRCPTR
SMARTiView protein in SMART
SM00202, SR, 9 hits
SUPFAMiSSF56487, SSF56487, 9 hits
PROSITEiView protein in PROSITE
PS00420, SRCR_1, 5 hits
PS50287, SRCR_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC163A_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P85521
Secondary accession number(s): C6KEM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: September 22, 2009
Last modified: August 12, 2020
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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