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UniProtKB - P85504 (TXP2_BRAAI)
Protein
Omega-theraphotoxin-Ba1b
Gene
N/A
Organism
Brachypelma albiceps (Mexican golden redrump tarantula) (Brachypelma ruhnaui)
Status
Functioni
Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity).
Has insecticidal activity to crickets (Acheta domesticus) (PubMed:19374957).
Is not toxic to mice (PubMed:19374957).
By similarity1 PublicationMiscellaneous
Does not inhibit insect and mice voltage-gated sodium channels (para/tipE, Nav1.2/SCN2A, Nav1.5/SCN5A).1 Publication
GO - Molecular functioni
- calcium channel regulator activity Source: UniProtKB-KW
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Omega-theraphotoxin-Ba1bCuratedShort name: Omega-TRTX-Ba1bCurated Alternative name(s): Ba21 Publication |
Organismi | Brachypelma albiceps (Mexican golden redrump tarantula) (Brachypelma ruhnaui) |
Taxonomic identifieri | 503929 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Araneae › Mygalomorphae › Theraphosidae › Brachypelma |
Organism-specific databases
ArachnoServeri | AS000401, omega-theraphotoxin-Ba1b |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 9.2 +-0.9 mg/kg in juvenile house crickets (Acheta domesticus).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000332948 | 1 – 39 | Omega-theraphotoxin-Ba1b1 PublicationAdd BLAST | 39 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 4 ↔ 17 | Combined sources1 Publication | ||
Disulfide bondi | 8 ↔ 31 | Combined sources1 Publication | ||
Disulfide bondi | 25 ↔ 36 | Combined sources1 Publication |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P85504 |
BMRBi | P85504 |
SMRi | P85504 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P85504 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR012625, Toxin_20 |
Pfami | View protein in Pfam PF08089, Toxin_20, 1 hit |
PROSITEi | View protein in PROSITE PS60022, HWTX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Molecular mass is 4440.67 Da. Determined by ESI. 1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KGH | NMR | - | A | 1-39 | [»] | |
AlphaFoldDBi | P85504 | |||||
BMRBi | P85504 | |||||
SMRi | P85504 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Organism-specific databases
ArachnoServeri | AS000401, omega-theraphotoxin-Ba1b |
Miscellaneous databases
EvolutionaryTracei | P85504 |
Family and domain databases
InterProi | View protein in InterPro IPR012625, Toxin_20 |
Pfami | View protein in Pfam PF08089, Toxin_20, 1 hit |
PROSITEi | View protein in PROSITE PS60022, HWTX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TXP2_BRAAI | |
Accessioni | P85504Primary (citable) accession number: P85504 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | April 29, 2008 | |
Last modified: | May 25, 2022 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families