Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proline-rich protein 5

Gene

PRR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.2 Publications

GO - Biological processi

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
SIGNORiP85299

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 5
Alternative name(s):
Protein observed with Rictor-1
Short name:
Protor-1
Gene namesi
Name:PRR5
Synonyms:PROTOR1
ORF Names:PP610
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000186654.20
HGNCiHGNC:31682 PRR5
MIMi609406 gene
neXtProtiNX_P85299

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi55615
OpenTargetsiENSG00000186654
PharmGKBiPA144596392

Polymorphism and mutation databases

BioMutaiPRR5
DMDMi160016058

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003081621 – 388Proline-rich protein 5Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP85299
PaxDbiP85299
PeptideAtlasiP85299
PRIDEiP85299
ProteomicsDBi57768
57769 [P85299-2]
57770 [P85299-3]
57771 [P85299-4]

PTM databases

iPTMnetiP85299
PhosphoSitePlusiP85299

Expressioni

Tissue specificityi

Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.2 Publications

Gene expression databases

BgeeiENSG00000186654
ExpressionAtlasiP85299 baseline and differential
GenevisibleiP85299 HS

Organism-specific databases

HPAiHPA054072

Interactioni

Subunit structurei

Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and RICTOR within the TORC2 complex.2 Publications

Protein-protein interaction databases

BioGridi120755, 6 interactors
IntActiP85299, 15 interactors
MINTiP85299
STRINGi9606.ENSP00000384848

Structurei

3D structure databases

ProteinModelPortaliP85299
SMRiP85299
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 95Interaction with RICTORAdd BLAST86
Regioni188 – 218Interaction with RICTORAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 27Poly-Ala4

Sequence similaritiesi

Belongs to the PROTOR family.Curated

Phylogenomic databases

eggNOGiKOG4406 Eukaryota
ENOG410XR4J LUCA
GeneTreeiENSGT00530000063981
HOGENOMiHOG000290687
HOVERGENiHBG067971
InParanoidiP85299
KOiK20411
OMAiSCILEKH
OrthoDBiEOG091G0VPK
PhylomeDBiP85299
TreeFamiTF314826

Family and domain databases

InterProiView protein in InterPro
IPR013745 Bit61/PRR5
IPR016159 Cullin_repeat-like_dom_sf
PfamiView protein in Pfam
PF08539 HbrB, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P85299-1) [UniParc]FASTAAdd to basket
Also known as: alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTLRRLKFM SSPSLSDLGK REPAAAADER GTQQRRACAN ATWNSIHNGV
60 70 80 90 100
IAVFQRKGLP DQELFSLNEG VRQLLKTELG SFFTEYLQNQ LLTKGMVILR
110 120 130 140 150
DKIRFYEGQK LLDSLAETWD FFFSDVLPML QAIFYPVQGK EPSVRQLALL
160 170 180 190 200
HFRNAITLSV KLEDALARAH ARVPPAIVQM LLVLQGVHES RGVTEDYLRL
210 220 230 240 250
ETLVQKVVSP YLGTYGLHSS EGPFTHSCIL EKRLLRRSRS GDVLAKNPVV
260 270 280 290 300
RSKSYNTPLL NPVQEHEAEG AAAGGTSIRR HSVSEMTSCP EPQGFSDPPG
310 320 330 340 350
QGPTGTFRSS PAPHSGPCPS RLYPTTQPPE QGLDPTRSSL PRSSPENLVD
360 370 380
QILESVDSDS EGIFIDFGRG RGSGMSDLEG SGGRQSVV
Length:388
Mass (Da):42,753
Last modified:October 23, 2007 - v1
Checksum:iFA6B90495623EF3F
GO
Isoform 2 (identifier: P85299-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     102-107: KIRFYE → MAPMPT

Show »
Length:287
Mass (Da):31,125
Checksum:i24E46CD123CA100E
GO
Isoform 3 (identifier: P85299-3) [UniParc]FASTAAdd to basket
Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:379
Mass (Da):41,551
Checksum:i1A0E3E17802AFD85
GO
Isoform 4 (identifier: P85299-4) [UniParc]FASTAAdd to basket
Also known as: gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:293
Mass (Da):32,061
Checksum:i63D42183C35C9A0B
GO
Isoform 5 (identifier: P85299-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MRTLR → MVCLELSQREAWGSGSPEKMPAQPEGLY

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):45,172
Checksum:i85B5B9159AB9350B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280R → W in BAA90999 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062230243V → M. Corresponds to variant dbSNP:rs36082900Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0016461 – 101Missing in isoform 2. 2 PublicationsAdd BLAST101
Alternative sequenceiVSP_0288841 – 95Missing in isoform 4. CuratedAdd BLAST95
Alternative sequenceiVSP_0288851 – 9Missing in isoform 3. Curated9
Alternative sequenceiVSP_0458831 – 5MRTLR → MVCLELSQREAWGSGSPEKM PAQPEGLY in isoform 5. 1 Publication5
Alternative sequenceiVSP_001648102 – 107KIRFYE → MAPMPT in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000192 mRNA Translation: BAA90999.1
AK055848 mRNA Translation: BAG51585.1
AF177331 mRNA Translation: AAG17975.1
Z93244 Genomic DNA No translation available.
Z98743 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73353.1
CH471138 Genomic DNA Translation: EAW73355.1
BC016921 mRNA Translation: AAH16921.1
BK005635 mRNA Translation: DAA05654.1
BK005636 mRNA Translation: DAA05655.1
BK005637 mRNA Translation: DAA05656.1
BK005638 mRNA Translation: DAA05657.1
BK005639 mRNA Translation: DAA05658.1
CCDSiCCDS14058.1
CCDS14059.1 [P85299-3]
CCDS56232.1 [P85299-5]
CCDS74875.1 [P85299-4]
RefSeqiNP_001017528.1, NM_001017528.2 [P85299-3]
NP_001017529.1, NM_001017529.2 [P85299-4]
NP_001017530.1, NM_001017530.1 [P85299-4]
NP_001185650.1, NM_001198721.1 [P85299-5]
NP_056181.2, NM_015366.3 [P85299-3]
NP_851850.1, NM_181333.3 [P85299-1]
UniGeneiHs.102336

Genome annotation databases

EnsembliENST00000006251; ENSP00000006251; ENSG00000186654 [P85299-3]
ENST00000336985; ENSP00000337464; ENSG00000186654 [P85299-1]
ENST00000403581; ENSP00000384848; ENSG00000186654 [P85299-5]
ENST00000611394; ENSP00000480357; ENSG00000186654 [P85299-3]
ENST00000617066; ENSP00000479623; ENSG00000186654 [P85299-4]
ENST00000624862; ENSP00000485597; ENSG00000186654 [P85299-4]
GeneIDi55615
KEGGihsa:55615
UCSCiuc003bew.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRR5_HUMAN
AccessioniPrimary (citable) accession number: P85299
Secondary accession number(s): B1AHF6
, B1AHG5, B3KP73, O75983, O95695, Q5BIW2, Q5EAJ8, Q5EAJ9, Q5XKJ6, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NSG0, Q9NVX8, Q9NXL1, Q9UH20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health