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UniProtKB - P85090 (OCE4_LEPOE)
Protein
Ocellatin-4
Gene
N/A
Organism
Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)
Status
Functioni
Has hemolytic activity against human erythrocytes (HC50=14.3 µM). Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=64 µM) and the Gram-negative bacterium E.coli ATCC 25922 (MIC=64 µM).
1 PublicationGO - Biological processi
- defense response to bacterium Source: UniProtKB-KW
- hemolysis in other organism Source: UniProtKB-KW
Keywordsi
Molecular function | Amphibian defense peptide, Antibiotic, Antimicrobial |
Biological process | Cytolysis, Hemolysis |
Names & Taxonomyi
Protein namesi | Recommended name: Ocellatin-4 |
Organismi | Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum) |
Taxonomic identifieri | 928525 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Hyloidea › Leptodactylidae › Leptodactylinae › Leptodactylus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000306195 | 1 – 21 | Ocellatin-41 PublicationAdd BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | Isoleucine amide1 Publication | 1 |
Keywords - PTMi
AmidationExpressioni
Tissue specificityi
Expressed by the skin dorsal glands.1 Publication
Structurei
Family & Domainsi
Sequence similaritiesi
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Molecular mass is 2274.24 Da. Determined by MALDI. 1 Publication
Cross-referencesi
Web resourcesi
The antimicrobial peptide database |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | OCE4_LEPOE | |
Accessioni | P85090Primary (citable) accession number: P85090 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | September 29, 2021 | |
This is version 22 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families