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Protein

Forkhead box protein K1

Gene

FOXK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene (By similarity). Important regulatory factor of the myogenic progenitor cell population (By similarity). Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells (By similarity). Represses myogenic differentiation by inhibiting MEFC acitivity (By similarity). Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi305 – 400Fork-headPROSITE-ProRule annotationAdd BLAST96

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5689603 UCH proteinases

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein K1
Alternative name(s):
Myocyte nuclear factor
Short name:
MNF
Gene namesi
Name:FOXK12 Publications
Synonyms:MNF1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164916.10
HGNCiHGNC:23480 FOXK1
MIMi616302 gene
neXtProtiNX_P85037

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi355H → A: No effect on interaction with DVL2. 1 Publication1

Organism-specific databases

DisGeNETi221937
OpenTargetsiENSG00000164916
PharmGKBiPA134978307

Polymorphism and mutation databases

BioMutaiFOXK1
DMDMi118572324

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002616672 – 733Forkhead box protein K1Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei161Omega-N-methylarginineCombined sources1
Modified residuei191Omega-N-methylarginineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei245PhosphothreonineBy similarity1
Modified residuei247PhosphothreonineBy similarity1
Modified residuei253PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei299PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei422PhosphothreonineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei436PhosphothreonineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Modified residuei459PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP85037
MaxQBiP85037
PaxDbiP85037
PeptideAtlasiP85037
PRIDEiP85037
ProteomicsDBi57762
57763 [P85037-2]

PTM databases

iPTMnetiP85037
PhosphoSitePlusiP85037

Expressioni

Tissue specificityi

Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.1 Publication

Gene expression databases

BgeeiENSG00000164916 Expressed in 212 organ(s), highest expression level in cerebellar vermis
CleanExiHS_FOXK1
ExpressionAtlasiP85037 baseline and differential
GenevisibleiP85037 HS

Organism-specific databases

HPAiHPA017998
HPA018864

Interactioni

Subunit structurei

Interacts with SIN3A and SIN3B (via PAH2) to form a complex which represses transcription (By similarity). Interacts with FOXO4 and MEF2C; both interactions inhibit FOXO4 and MEF2C transactivation activity (By similarity). Interacts with DVL2 and DVL3; the interaction induces DVL2 nuclear translocation (PubMed:25805136).By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi128769, 100 interactors
IntActiP85037, 67 interactors
MINTiP85037
STRINGi9606.ENSP00000328720

Structurei

3D structure databases

ProteinModelPortaliP85037
SMRiP85037
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 175FHAPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 40Interaction with SIN3A and SIN3BBy similarityAdd BLAST39
Regioni95 – 420Required for interaction with FOXO4 and MEF2CBy similarityAdd BLAST326

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 96Ala-richSequence analysisAdd BLAST87
Compositional biasi35 – 62Pro-richSequence analysisAdd BLAST28

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00920000148974
HOGENOMiHOG000072588
HOVERGENiHBG051649
InParanoidiP85037
KOiK09404
OMAiCEVGPEE
OrthoDBiEOG091G099F
PhylomeDBiP85037
TreeFamiTF325718

Family and domain databases

CDDicd00059 FH, 1 hit
cd00060 FHA, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR001766 Fork_head_dom
IPR008984 SMAD_FHA_dom_sf
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SM00240 FHA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: P85037-1) [UniParc]FASTAAdd to basket
Also known as: a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEVGEDSGA RALLALRSAP CSPVLCAAAA AAAFPAAAPP PAPAQPQPPP
60 70 80 90 100
GPPPPPPPPL PPGAIAGAGS SGGSSGVSGD SAVAGAAPAL VAAAAASVRQ
110 120 130 140 150
SPGPALARLE GREFEFLMRQ PSVTIGRNSS QGSVDLSMGL SSFISRRHLQ
160 170 180 190 200
LSFQEPHFYL RCLGKNGVFV DGAFQRRGAP ALQLPKQCTF RFPSTAIKIQ
210 220 230 240 250
FTSLYHKEEA PASPLRPLYP QISPLKIHIP EPDLRSMVSP VPSPTGTISV
260 270 280 290 300
PNSCPASPRG AGSSSYRFVQ NVTSDLQLAA EFAAKAASEQ QADTSGGDSP
310 320 330 340 350
KDESKPPFSY AQLIVQAISS AQDRQLTLSG IYAHITKHYP YYRTADKGWQ
360 370 380 390 400
NSIRHNLSLN RYFIKVPRSQ EEPGKGSFWR IDPASEAKLV EQAFRKRRQR
410 420 430 440 450
GVSCFRTPFG PLSSRSAPAS PTHPGLMSPR SGGLQTPECL SREGSPIPHD
460 470 480 490 500
PEFGSKLASV PEYRYSQSAP GSPVSAQPVI MAVPPRPSSL VAKPVAYMPA
510 520 530 540 550
SIVTSQQPAG HAIHVVQQAP TVTMVRVVTT SANSANGYIL TSQGAAGGSH
560 570 580 590 600
DAAGAAVLDL GSEARGLEEK PTIAFATIPA AGGVIQTVAS QMAPGVPGHT
610 620 630 640 650
VTILQPATPV TLGQHHLPVR AVTQNGKHAV PTNSLAGNAY ALTSPLQLLA
660 670 680 690 700
TQASSSAPVV VTRVCEVGPK EPAAAVAATA TTTPATATTA SASASSTGEP
710 720 730
EVKRSRVEEP SGAVTTPAGV IAAAGPQGPG TGE
Note: No experimental confirmation available.Curated
Length:733
Mass (Da):75,457
Last modified:November 28, 2006 - v1
Checksum:iC9EF4AC3C959A1C3
GO
Isoform 21 Publication (identifier: P85037-2) [UniParc]FASTAAdd to basket
Also known as: b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.
     164-187: GKNGVFVDGAFQRRGAPALQLPKQ → MAYCLGVNFVPSRFCYQLHRLLLR

Note: No experimental confirmation available.Curated
Show »
Length:570
Mass (Da):59,702
Checksum:iFF1010BC65780B22
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ26U3KQ26_HUMAN
Forkhead box protein K1
FOXK1
109Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144I → V in CB959941 (PubMed:15489334).Curated1
Sequence conflicti154 – 155QE → KS in CB959941 (PubMed:15489334).Curated2
Sequence conflicti159Y → S in CB959941 (PubMed:15489334).Curated1
Sequence conflicti217P → A in AW206906 (Ref. 4) Curated1
Sequence conflicti232P → T in AW206906 (Ref. 4) Curated1
Sequence conflicti437 – 445Missing in AK122663 (PubMed:14702039).Curated9

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0522391 – 163Missing in isoform 2. 2 PublicationsAdd BLAST163
Alternative sequenceiVSP_052240164 – 187GKNGV…QLPKQ → MAYCLGVNFVPSRFCYQLHR LLLR in isoform 2. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122663 mRNA No translation available.
AC072054 Genomic DNA No translation available.
AC092428 Genomic DNA No translation available.
AC092610 Genomic DNA No translation available.
BC038434 mRNA No translation available.
CB959941 mRNA No translation available.
AW206906 mRNA No translation available.
CCDSiCCDS34591.1 [P85037-1]
RefSeqiNP_001032242.1, NM_001037165.1 [P85037-1]
XP_011513493.1, XM_011515191.2 [P85037-2]
UniGeneiHs.487393

Genome annotation databases

EnsembliENST00000328914; ENSP00000328720; ENSG00000164916 [P85037-1]
GeneIDi221937
KEGGihsa:221937
UCSCiuc003snc.2 human [P85037-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122663 mRNA No translation available.
AC072054 Genomic DNA No translation available.
AC092428 Genomic DNA No translation available.
AC092610 Genomic DNA No translation available.
BC038434 mRNA No translation available.
CB959941 mRNA No translation available.
AW206906 mRNA No translation available.
CCDSiCCDS34591.1 [P85037-1]
RefSeqiNP_001032242.1, NM_001037165.1 [P85037-1]
XP_011513493.1, XM_011515191.2 [P85037-2]
UniGeneiHs.487393

3D structure databases

ProteinModelPortaliP85037
SMRiP85037
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128769, 100 interactors
IntActiP85037, 67 interactors
MINTiP85037
STRINGi9606.ENSP00000328720

PTM databases

iPTMnetiP85037
PhosphoSitePlusiP85037

Polymorphism and mutation databases

BioMutaiFOXK1
DMDMi118572324

Proteomic databases

EPDiP85037
MaxQBiP85037
PaxDbiP85037
PeptideAtlasiP85037
PRIDEiP85037
ProteomicsDBi57762
57763 [P85037-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328914; ENSP00000328720; ENSG00000164916 [P85037-1]
GeneIDi221937
KEGGihsa:221937
UCSCiuc003snc.2 human [P85037-1]

Organism-specific databases

CTDi221937
DisGeNETi221937
EuPathDBiHostDB:ENSG00000164916.10
GeneCardsiFOXK1
HGNCiHGNC:23480 FOXK1
HPAiHPA017998
HPA018864
MIMi616302 gene
neXtProtiNX_P85037
OpenTargetsiENSG00000164916
PharmGKBiPA134978307
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00920000148974
HOGENOMiHOG000072588
HOVERGENiHBG051649
InParanoidiP85037
KOiK09404
OMAiCEVGPEE
OrthoDBiEOG091G099F
PhylomeDBiP85037
TreeFamiTF325718

Enzyme and pathway databases

ReactomeiR-HSA-5689603 UCH proteinases

Miscellaneous databases

ChiTaRSiFOXK1 human
GeneWikiiFOXK1
GenomeRNAii221937
PROiPR:P85037
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164916 Expressed in 212 organ(s), highest expression level in cerebellar vermis
CleanExiHS_FOXK1
ExpressionAtlasiP85037 baseline and differential
GenevisibleiP85037 HS

Family and domain databases

CDDicd00059 FH, 1 hit
cd00060 FHA, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR001766 Fork_head_dom
IPR008984 SMAD_FHA_dom_sf
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SM00240 FHA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXK1_HUMAN
AccessioniPrimary (citable) accession number: P85037
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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