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UniProtKB - P85037 (FOXK1_HUMAN)

>sp|P85037|FOXK1_HUMAN Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1
MAEVGEDSGARALLALRSAPCSPVLCAAAAAAAFPAAAPPPAPAQPQPPPGPPPPPPPPL
PPGAIAGAGSSGGSSGVSGDSAVAGAAPALVAAAAASVRQSPGPALARLEGREFEFLMRQ
PSVTIGRNSSQGSVDLSMGLSSFISRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRRGAP
ALQLPKQCTFRFPSTAIKIQFTSLYHKEEAPASPLRPLYPQISPLKIHIPEPDLRSMVSP
VPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTSDLQLAAEFAAKAASEQQADTSGGDSP
KDESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLN
RYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFRTPFGPLSSRSAPAS
PTHPGLMSPRSGGLQTPECLSREGSPIPHDPEFGSKLASVPEYRYSQSAPGSPVSAQPVI
MAVPPRPSSLVAKPVAYMPASIVTSQQPAGHAIHVVQQAPTVTMVRVVTTSANSANGYIL
TSQGAAGGSHDAAGAAVLDLGSEARGLEEKPTIAFATIPAAGGVIQTVASQMAPGVPGHT
VTILQPATPVTLGQHHLPVRAVTQNGKHAVPTNSLAGNAYALTSPLQLLATQASSSAPVV
VTRVCEVGPKEPAAAVAATATTTPATATTASASASSTGEPEVKRSRVEEPSGAVTTPAGV
IAAAGPQGPGTGE

Entry version 152 (25 May 2022)
Sequence version 1 (28 Nov 2006)
Previous versions | rss

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Protein

Forkhead box protein K1

Gene

FOXK1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity).

Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796).

Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity).

Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity).

Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity).

Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity).

Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity).

Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity).

Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity).

Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity).

Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity).

Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity).

Represses myogenic differentiation by inhibiting MEFC activity (By similarity).

Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136).

Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164).

By similarity3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	305 – 400	Fork-headPROSITE-ProRule annotationAdd BLAST		96

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Differentiation, Host-virus interaction, Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

PathwayCommonsⁱ	P85037
Reactomeⁱ	R-HSA-5689603, UCH proteinases
SignaLinkⁱ	P85037

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Forkhead box protein K12 Publications Alternative name(s): Myocyte nuclear factor1 Publication Short name: MNF1 Publication
Gene namesⁱ	Name:FOXK12 PublicationsImported Synonyms:MNF1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23480, FOXK1
MIMⁱ	616302, gene
neXtProtⁱ	NX_P85037
VEuPathDBⁱ	HostDB:ENSG00000164916

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	127	R → A: Reduced interaction with BAP1. 1 Publication		1
Mutagenesisⁱ	355	H → A: Reduced DNA-binding and ability to repress transcription without affecting interaction with SRF. No effect on interaction with DVL2. 2 Publications		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	221937
Open Targets More...OpenTargetsⁱ	ENSG00000164916
PharmGKBⁱ	PA134978307

Miscellaneous databases

Pharosⁱ	P85037, Tbio

Pharosⁱ

P85037, Tbio

Genetic variation databases

BioMutaⁱ	FOXK1
DMDMⁱ	118572324

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000261667	2 – 733	Forkhead box protein K1Add BLAST		732

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	101	PhosphoserineCombined sources	1
Modified residueⁱ	161	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	191	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	213	PhosphoserineCombined sources	1
Modified residueⁱ	223	PhosphoserineCombined sources	1
Modified residueⁱ	239	PhosphoserineCombined sources	1
Modified residueⁱ	243	PhosphoserineCombined sources	1
Modified residueⁱ	245	PhosphothreonineBy similarity	1
Modified residueⁱ	247	PhosphothreonineBy similarity	1
Modified residueⁱ	253	PhosphoserineCombined sources	1
Modified residueⁱ	257	PhosphoserineCombined sources	1
Modified residueⁱ	295	PhosphoserineBy similarity	1
Modified residueⁱ	299	PhosphoserineCombined sources	1
Modified residueⁱ	416	PhosphoserineCombined sources	1
Modified residueⁱ	420	PhosphoserineCombined sources	1
Modified residueⁱ	422	PhosphothreonineCombined sources	1
Modified residueⁱ	428	PhosphoserineCombined sources	1
Modified residueⁱ	436	PhosphothreonineCombined sources	1
Modified residueⁱ	441	PhosphoserineCombined sources	1
Modified residueⁱ	445	PhosphoserineCombined sources	1
Modified residueⁱ	459	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with YWHAE/14-3-3-epsilon and retention in the cytoplasm. In response to mTORC1 signaling, phosphorylation by GSK3 is prevented, leading to translocation to the nucleus.By similarity

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	P85037
jPOSTⁱ	P85037
MassIVEⁱ	P85037
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P85037
PaxDbⁱ	P85037
PeptideAtlas More...PeptideAtlasⁱ	P85037
PRIDEⁱ	P85037
ProteomicsDBⁱ	57762 [P85037-1] 57763 [P85037-2]

PTM databases

GlyGenⁱ	P85037, 28 sites, 2 O-linked glycans (28 sites)
iPTMnetⁱ	P85037
PhosphoSitePlusⁱ	P85037

Expressionⁱ

Tissue specificityⁱ

Expressed both developing and adult tissues (PubMed:15289879). In adults, significant expression is seen in tumors of the brain, colon and lymph node (PubMed:15289879).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000164916, Expressed in cerebellar vermis and 226 other tissues
ExpressionAtlasⁱ	P85037, baseline and differential
Genevisibleⁱ	P85037, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000164916, Low tissue specificity

HPAⁱ

ENSG00000164916, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts with SIN3A and SIN3B (via PAH2) to form a complex which represses transcription (By similarity).

Component of SIN3A-, but not SIN3B-, containing multiprotein complexes (By similarity).

Interacts with FOXO4 and MEF2C; both interactions inhibit FOXO4 and MEF2C transactivation activity (By similarity).

Interacts (when phosphorylated) with YWHAE/14-3-3-epsilon; promotes sequestration in the cytoplasm and leads to impaired ability to bind DNA (By similarity).

Interacts with FHL2 (By similarity).

Interacts with SRF (PubMed:17670796).

Interacts with DVL2 and DVL3; the interaction induces DVL2 nuclear translocation (PubMed:25805136).

Interacts with BAP1 (when phosphorylated) (PubMed:25451922).

By similarity3 Publications

Binary interactionsⁱ

Hide details

P85037

With	#Exp.	IntAct
FOXO3 [O43524]	2	EBI-2509974,EBI-1644164
IRF2 [P14316]	3	EBI-2509974,EBI-2866589

GO - Molecular functionⁱ

14-3-3 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- "mTORC1 promotes metabolic reprogramming by the suppression of GSK3-dependent foxk1 phosphorylation."
  He L., Gomes A.P., Wang X., Yoon S.O., Lee G., Nagiec M.J., Cho S., Chavez A., Islam T., Yu Y., Asara J.M., Kim B.Y., Blenis J.
  Mol. Cell 70:949-960(2018) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	128769, 183 interactors
IntActⁱ	P85037, 111 interactors
Molecular INTeraction database More...MINTⁱ	P85037
STRINGⁱ	9606.ENSP00000328720

Miscellaneous databases

RNActⁱ	P85037, protein

RNActⁱ

P85037, protein

Structureⁱ

3D structure databases

AlphaFoldDBⁱ	P85037
BMRBⁱ	P85037
SMRⁱ	P85037
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	123 – 175	FHAPROSITE-ProRule annotationAdd BLAST		53

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 40	Interaction with SIN3A and SIN3BBy similarityAdd BLAST	39
Regionⁱ	36 – 79	DisorderedSequence analysisAdd BLAST	44
Regionⁱ	95 – 420	Required for interaction with FOXO4 and MEF2CBy similarityAdd BLAST	326
Regionⁱ	287 – 306	DisorderedSequence analysisAdd BLAST	20
Regionⁱ	413 – 436	DisorderedSequence analysisAdd BLAST	24
Regionⁱ	676 – 733	DisorderedSequence analysisAdd BLAST	58

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	36 – 64	Pro residuesSequence analysisAdd BLAST		29
Compositional biasⁱ	679 – 700	Polar residuesSequence analysisAdd BLAST		22

Phylogenomic databases

eggNOGⁱ	KOG2294, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159507
HOGENOMⁱ	CLU_022344_0_0_1
InParanoidⁱ	P85037
OMAⁱ	VTIGQHH
Database of Orthologous Groups More...OrthoDBⁱ	1270467at2759
PhylomeDBⁱ	P85037
TreeFamⁱ	TF325718

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059, FH, 1 hit cd00060, FHA, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000253, FHA_dom IPR001766, Fork_head_dom IPR008984, SMAD_FHA_dom_sf IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00498, FHA, 1 hit PF00250, Forkhead, 1 hit
PRINTSⁱ	PR00053, FORKHEAD
SMARTⁱ	View protein in SMART SM00339, FH, 1 hit SM00240, FHA, 1 hit
SUPFAMⁱ	SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 12 Publications (identifier: P85037-1) [UniParc]FASTA Add to basket

Also known as: a1 Publication

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEVGEDSGA RALLALRSAP CSPVLCAAAA AAAFPAAAPP PAPAQPQPPP 
        60         70         80         90        100
GPPPPPPPPL PPGAIAGAGS SGGSSGVSGD SAVAGAAPAL VAAAAASVRQ 
       110        120        130        140        150
SPGPALARLE GREFEFLMRQ PSVTIGRNSS QGSVDLSMGL SSFISRRHLQ 
       160        170        180        190        200
LSFQEPHFYL RCLGKNGVFV DGAFQRRGAP ALQLPKQCTF RFPSTAIKIQ 
       210        220        230        240        250
FTSLYHKEEA PASPLRPLYP QISPLKIHIP EPDLRSMVSP VPSPTGTISV 
       260        270        280        290        300
PNSCPASPRG AGSSSYRFVQ NVTSDLQLAA EFAAKAASEQ QADTSGGDSP 
       310        320        330        340        350
KDESKPPFSY AQLIVQAISS AQDRQLTLSG IYAHITKHYP YYRTADKGWQ 
       360        370        380        390        400
NSIRHNLSLN RYFIKVPRSQ EEPGKGSFWR IDPASEAKLV EQAFRKRRQR 
       410        420        430        440        450
GVSCFRTPFG PLSSRSAPAS PTHPGLMSPR SGGLQTPECL SREGSPIPHD 
       460        470        480        490        500
PEFGSKLASV PEYRYSQSAP GSPVSAQPVI MAVPPRPSSL VAKPVAYMPA 
       510        520        530        540        550
SIVTSQQPAG HAIHVVQQAP TVTMVRVVTT SANSANGYIL TSQGAAGGSH 
       560        570        580        590        600
DAAGAAVLDL GSEARGLEEK PTIAFATIPA AGGVIQTVAS QMAPGVPGHT 
       610        620        630        640        650
VTILQPATPV TLGQHHLPVR AVTQNGKHAV PTNSLAGNAY ALTSPLQLLA 
       660        670        680        690        700
TQASSSAPVV VTRVCEVGPK EPAAAVAATA TTTPATATTA SASASSTGEP 
       710        720        730 
EVKRSRVEEP SGAVTTPAGV IAAAGPQGPG TGE

Length:733

Mass (Da):75,457

Last modified:November 28, 2006 - v1

Checksum:ⁱC9EF4AC3C959A1C3

Isoform 21 Publication (identifier: P85037-2) [UniParc]FASTA Add to basket

Also known as: b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
1-163: Missing.
164-187: GKNGVFVDGAFQRRGAPALQLPKQ → MAYCLGVNFVPSRFCYQLHRLLLR

« Hide

        10         20         30         40         50
MAYCLGVNFV PSRFCYQLHR LLLRCTFRFP STAIKIQFTS LYHKEEAPAS 
        60         70         80         90        100
PLRPLYPQIS PLKIHIPEPD LRSMVSPVPS PTGTISVPNS CPASPRGAGS 
       110        120        130        140        150
SSYRFVQNVT SDLQLAAEFA AKAASEQQAD TSGGDSPKDE SKPPFSYAQL 
       160        170        180        190        200
IVQAISSAQD RQLTLSGIYA HITKHYPYYR TADKGWQNSI RHNLSLNRYF 
       210        220        230        240        250
IKVPRSQEEP GKGSFWRIDP ASEAKLVEQA FRKRRQRGVS CFRTPFGPLS 
       260        270        280        290        300
SRSAPASPTH PGLMSPRSGG LQTPECLSRE GSPIPHDPEF GSKLASVPEY 
       310        320        330        340        350
RYSQSAPGSP VSAQPVIMAV PPRPSSLVAK PVAYMPASIV TSQQPAGHAI 
       360        370        380        390        400
HVVQQAPTVT MVRVVTTSAN SANGYILTSQ GAAGGSHDAA GAAVLDLGSE 
       410        420        430        440        450
ARGLEEKPTI AFATIPAAGG VIQTVASQMA PGVPGHTVTI LQPATPVTLG 
       460        470        480        490        500
QHHLPVRAVT QNGKHAVPTN SLAGNAYALT SPLQLLATQA SSSAPVVVTR 
       510        520        530        540        550
VCEVGPKEPA AAVAATATTT PATATTASAS ASSTGEPEVK RSRVEEPSGA 
       560        570
VTTPAGVIAA AGPQGPGTGE

Show »

Length:570

Mass (Da):59,702

Checksum:ⁱFF1010BC65780B22

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	U3KQ26	U3KQ26_HUMAN		Forkhead box protein K1 Forkhead box protein K1	FOXK1	109	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	144	I → V in CB959941 (PubMed:15489334).Curated	1
Sequence conflictⁱ	154 – 155	QE → KS in CB959941 (PubMed:15489334).Curated	2
Sequence conflictⁱ	159	Y → S in CB959941 (PubMed:15489334).Curated	1
Sequence conflictⁱ	217	P → A in AW206906 (Ref. 4) Curated	1
Sequence conflictⁱ	232	P → T in AW206906 (Ref. 4) Curated	1
Sequence conflictⁱ	437 – 445	Missing in AK122663 (PubMed:14702039).Curated	9

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_052239	1 – 163	Missing in isoform 2. 2 PublicationsAdd BLAST		163
Alternative sequenceⁱVSP_052240	164 – 187	GKNGV…QLPKQ → MAYCLGVNFVPSRFCYQLHR LLLR in isoform 2. 2 PublicationsAdd BLAST		24

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK122663 mRNA No translation available. AC072054 Genomic DNA No translation available. AC092428 Genomic DNA No translation available. AC092610 Genomic DNA No translation available. BC038434 mRNA No translation available. CB959941 mRNA No translation available. AW206906 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34591.1 [P85037-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001032242.1, NM_001037165.1 [P85037-1] XP_011513493.1, XM_011515191.2

Genome annotation databases

Ensemblⁱ	ENST00000328914.5; ENSP00000328720.4; ENSG00000164916.11
GeneIDⁱ	221937
KEGGⁱ	hsa:221937
MANE-Selectⁱ	ENST00000328914.5; ENSP00000328720.4; NM_001037165.2; NP_001032242.1
UCSC genome browser More...UCSCⁱ	uc003snc.2, human [P85037-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P85037	Forkhead box K1 (Fragment)		synthetic construct		362	UniRef100_P85037

Protein	Similar proteins		Species	Score	Length	Source
P85037	Forkhead box K1 (Fragment)		synthetic construct		362	UniRef90_P85037
Forkhead box K1		CEBIM		740
Forkhead box K1		CALJA		738
FOXK1 isoform 1		PANTR		735
Forkhead box K1		PANPA		591
+21
P85037-2	Fork-head domain-containing protein (Fragment)		MACMU		547	UniRef90_P85037-2
+1

Protein	Similar proteins		Species	Score	Length	Source
P85037	Forkhead box protein K1	)	MOUSE		719	UniRef50_P42128
Forkhead box K1		MUSSI		719
Forkhead box K1		RAT		719
Forkhead box K1		PERMB		692
Forkhead box protein K1		MICOH		546
+210
P85037-2	Fork-head domain-containing protein (Fragment)		MACMU		547	UniRef50_P85037-2
Uncharacterized protein		CHIPU		662
Uncharacterized protein		CALMI		622
Forkhead box K1		MELGA		595
Fork-head domain-containing protein		NOMLE		610
+640

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK122663 mRNA No translation available. AC072054 Genomic DNA No translation available. AC092428 Genomic DNA No translation available. AC092610 Genomic DNA No translation available. BC038434 mRNA No translation available. CB959941 mRNA No translation available. AW206906 mRNA No translation available.
CCDSⁱ	CCDS34591.1 [P85037-1]
RefSeqⁱ	NP_001032242.1, NM_001037165.1 [P85037-1] XP_011513493.1, XM_011515191.2

3D structure databases

AlphaFoldDBⁱ	P85037
BMRBⁱ	P85037
SMRⁱ	P85037
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	128769, 183 interactors
IntActⁱ	P85037, 111 interactors
MINTⁱ	P85037
STRINGⁱ	9606.ENSP00000328720

PTM databases

GlyGenⁱ	P85037, 28 sites, 2 O-linked glycans (28 sites)
iPTMnetⁱ	P85037
PhosphoSitePlusⁱ	P85037

Genetic variation databases

BioMutaⁱ	FOXK1
DMDMⁱ	118572324

Proteomic databases

EPDⁱ	P85037
jPOSTⁱ	P85037
MassIVEⁱ	P85037
MaxQBⁱ	P85037
PaxDbⁱ	P85037
PeptideAtlasⁱ	P85037
PRIDEⁱ	P85037
ProteomicsDBⁱ	57762 [P85037-1] 57763 [P85037-2]

Protocols and materials databases

Antibodypediaⁱ	11250, 221 antibodies from 30 providers
The DNASU plasmid repository More...DNASUⁱ	221937

Genome annotation databases

Ensemblⁱ	ENST00000328914.5; ENSP00000328720.4; ENSG00000164916.11
GeneIDⁱ	221937
KEGGⁱ	hsa:221937
MANE-Selectⁱ	ENST00000328914.5; ENSP00000328720.4; NM_001037165.2; NP_001032242.1
UCSCⁱ	uc003snc.2, human [P85037-1]

Organism-specific databases

CTDⁱ	221937
DisGeNETⁱ	221937
GeneCardsⁱ	FOXK1
HGNCⁱ	HGNC:23480, FOXK1
HPAⁱ	ENSG00000164916, Low tissue specificity
MIMⁱ	616302, gene
neXtProtⁱ	NX_P85037
OpenTargetsⁱ	ENSG00000164916
PharmGKBⁱ	PA134978307
VEuPathDBⁱ	HostDB:ENSG00000164916
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2294, Eukaryota
GeneTreeⁱ	ENSGT00940000159507
HOGENOMⁱ	CLU_022344_0_0_1
InParanoidⁱ	P85037
OMAⁱ	VTIGQHH
OrthoDBⁱ	1270467at2759
PhylomeDBⁱ	P85037
TreeFamⁱ	TF325718

Enzyme and pathway databases

PathwayCommonsⁱ	P85037
Reactomeⁱ	R-HSA-5689603, UCH proteinases
SignaLinkⁱ	P85037

Miscellaneous databases

BioGRID-ORCSⁱ	221937, 98 hits in 1117 CRISPR screens
ChiTaRSⁱ	FOXK1, human
GeneWikiⁱ	FOXK1
GenomeRNAiⁱ	221937
Pharosⁱ	P85037, Tbio
Protein Ontology More...PROⁱ	PR:P85037
RNActⁱ	P85037, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164916, Expressed in cerebellar vermis and 226 other tissues
ExpressionAtlasⁱ	P85037, baseline and differential
Genevisibleⁱ	P85037, HS

Family and domain databases

CDDⁱ	cd00059, FH, 1 hit cd00060, FHA, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000253, FHA_dom IPR001766, Fork_head_dom IPR008984, SMAD_FHA_dom_sf IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00498, FHA, 1 hit PF00250, Forkhead, 1 hit
PRINTSⁱ	PR00053, FORKHEAD
SMARTⁱ	View protein in SMART SM00339, FH, 1 hit SM00240, FHA, 1 hit
SUPFAMⁱ	SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXK1_HUMAN
Accessionⁱ	P85037Primary (citable) accession number: P85037
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	November 28, 2006
	Last modified:	May 25, 2022
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P85037 (FOXK1_HUMAN)

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Forkhead box protein K1

FOXK1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Keywords - Cellular componenti

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Genetic variation databases

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Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

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Gene expression databases

Organism-specific databases

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P85037

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3D structure databases

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Domains and Repeats

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Compositional bias

Phylogenomic databases

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Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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Protein-protein interaction databases

PTM databases

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Proteomic databases

Protocols and materials databases

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Enzyme and pathway databases

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Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ