UniProtKB - P85011 (CA1E_CONRE)
Protein
Alpha-conotoxin-like Reg1e
Gene
N/A
Organism
Conus regius (Crown cone)
Status
Functioni
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity
Caution
Has the same mature sequence than RgIA (AC P0C1D0). RgIA could therefore be the precursor of Reg1e, except that RgIA does not have the C-terminal Gly residue required for C-terminal amidation of Reg1e.Curated
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-conotoxin-like Reg1e1 Publication |
Organismi | Conus regius (Crown cone) |
Taxonomic identifieri | 101314 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Stephanoconus |
Organism-specific databases
ConoServeri | 30 Reg1e |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- other organism postsynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000259387 | 1 – 12 | Alpha-conotoxin-like Reg1e1 PublicationAdd BLAST | 12 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 2 ↔ 8 | By similarity | ||
Disulfide bondi | 3 ↔ 12 | By similarity | ||
Modified residuei | 6 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 12 | Cysteine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Disulfide bond, HydroxylationExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Family & Domainsi
Domaini
The cysteine framework is I (CC-C-C). Alpha4/3 pattern.Curated
Sequence similaritiesi
Belongs to the conotoxin A superfamily.Curated
Family and domain databases
InterProi | View protein in InterPro IPR018072 Conotoxin_a-typ_CS |
PROSITEi | View protein in PROSITE PS60014 ALPHA_CONOTOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
ConoServeri | 30 Reg1e |
Family and domain databases
InterProi | View protein in InterPro IPR018072 Conotoxin_a-typ_CS |
PROSITEi | View protein in PROSITE PS60014 ALPHA_CONOTOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CA1E_CONRE | |
Accessioni | P85011Primary (citable) accession number: P85011 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | September 12, 2018 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families