UniProtKB - P84845 (CT5A_CONSP)
Protein
Conotoxin sr5a
Gene
N/A
Organism
Conus spurius (Alphabet cone)
Status
Functioni
When injected intracranially into 9-day-old mice, causes transient symptoms, including extension of the body and clockwise and counter-clockwise turns, that last 3 to 4 minutes. When injected intracranially into 16-day-old mice, causes transient symptoms, including agitated breathing and occasional turning followed by scratching and grooming behavior, that last for 15-19 minutes.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: UniProtKB
Keywordsi
Molecular function | Neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Conotoxin sr5aAlternative name(s): Sr5.1 Sr5.2 Sr5.3 |
Organismi | Conus spurius (Alphabet cone) |
Taxonomic identifieri | 192919 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Lindaconus |
Organism-specific databases
ConoServeri | 1618 SrVA 3699 SrVA precursor 3700 SrVA precursor 3782 SrVA precursor |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
PropeptideiPRO_0000392714 | 23 – 44 | CuratedAdd BLAST | 22 | |
PeptideiPRO_0000235846 | 47 – 59 | Conotoxin sr5a1 PublicationAdd BLAST | 13 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 51 ↔ 58 | 1 Publication | ||
Disulfide bondi | 52 ↔ 59 | 1 Publication |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Family & Domainsi
Domaini
The cysteine framework is V (CC-CC).Curated
Sequence similaritiesi
Belongs to the conotoxin T superfamily.1 Publication
Keywords - Domaini
SignalFamily and domain databases
InterProi | View protein in InterPro IPR031565 T-conotoxin |
Pfami | View protein in Pfam PF16981 Chi-conotoxin, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform sr5a (identifier: P84845-1) [UniParc]FASTAAdd to basket
Also known as: Sr5.1
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MRCLPVFVIL LLLIASAPSV DAQLKTKDDV PLASFHDNAK GTQHKRIINW
CCLIFYQCC
Isoform Sr5.2 (identifier: P84845-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
22-36: Missing.
Mass spectrometryi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 7 | F → L in Sr5.3. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038848 | 22 – 36 | Missing in isoform Sr5.2. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ646602 mRNA Translation: ACN22840.1 FJ646603 mRNA Translation: ACN22841.1 FJ646604 mRNA Translation: ACN22842.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ646602 mRNA Translation: ACN22840.1 FJ646603 mRNA Translation: ACN22841.1 FJ646604 mRNA Translation: ACN22842.1 |
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
ConoServeri | 1618 SrVA 3699 SrVA precursor 3700 SrVA precursor 3782 SrVA precursor |
Family and domain databases
InterProi | View protein in InterPro IPR031565 T-conotoxin |
Pfami | View protein in Pfam PF16981 Chi-conotoxin, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CT5A_CONSP | |
Accessioni | P84845Primary (citable) accession number: P84845 Secondary accession number(s): C0KYC0, C0KYC1, C0KYC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | March 23, 2010 | |
Last modified: | September 12, 2018 | |
This is version 22 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families