UniProtKB - P84810 (LV1A_BUTOC)
Protein
Lipolysis-activating peptide 1-alpha chain
Gene
N/A
Organism
Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Status
Functioni
The heterodimer non-edited LVP1 induces lipolysis in rat adipocytes. Induction of lipolysis by LVP1 appears to be mediated through the beta-2 adrenergic receptor pathway (ADRB2). Intracerebroventricular injection is not toxic to mice.1 Publication
The edited BmKBTx-like, similar to beta-toxins, may modulate voltage-gated sodium channels (Nav) and may block voltage-gated potassium channels (Kv).1 Publication
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response Source: UniProtKB
- positive regulation of lipid catabolic process Source: UniProtKB
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Lipolysis-activating peptide 1-alpha chainShort name: BotLVP1-alpha Short name: LVP1-alpha Cleaved into the following chain: |
Organismi | Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus) |
Taxonomic identifieri | 6871 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Buthus › |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000232422 | 23 – 91 | Lipolysis-activating peptide 1-alpha chainAdd BLAST | 69 | |
ChainiPRO_0000394866 | 23 – 78 | Neurotoxin BmKBTx-likeBy similarityAdd BLAST | 56 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 61 | PROSITE-ProRule annotation | ||
Disulfide bondi | 47 ↔ 66 | PROSITE-ProRule annotation | ||
Disulfide bondi | 51 ↔ 68 | PROSITE-ProRule annotation | ||
Disulfide bondi | 86 | Interchain (with C-90 in BotLVP1 chain beta)Curated |
Keywords - PTMi
Disulfide bondProteomic databases
PRIDEi | P84810 |
Expressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Interactioni
Subunit structurei
Monomer (edited version) and heterodimer (non-edited version) of this alpha chain and a beta chain (AC P84809).1 Publication
Structurei
3D structure databases
ProteinModelPortali | P84810 |
SMRi | P84810 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 87 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the long (3 C-C) scorpion toxin superfamily.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P84810-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMKLVLFGII VILFSLIGSI HGISGNYPLN PYGGYYYCTI LGENEYCKKI
60 70 80 90
CRIHGVRYGY CYDSACWCET LKDEDVSVWN AVKKHCKNPY L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | Missing AA sequence (PubMed:15680238).Curated | 1 |
RNA editingi
Edited at position 79.By similarity
The stop codon (UGA) at position 79 is created by RNA editing.By similarity
The stop codon (UGA) at position 79 is created by RNA editing.By similarity
Mass spectrometryi
Keywords - Coding sequence diversityi
RNA editingSimilar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P84810 |
SMRi | P84810 |
ModBasei | Search... |
MobiDBi | Search... |
Proteomic databases
PRIDEi | P84810 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | LV1A_BUTOC | |
Accessioni | P84810Primary (citable) accession number: P84810 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | April 18, 2006 | |
Last modified: | December 5, 2018 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families