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UniProtKB - P84776 (PA2H_PROMB)
Protein
Basic phospholipase A2 homolog zhaoermiatoxin
Gene
N/A
Organism
Protobothrops mangshanensis (Mangshan pitviper) (Zhaoermia mangshanensis)
Status
Functioni
Snake venom phospholipase A2 homolog that induces myonecrosis, and edema. Has low myotoxic activity.
1 PublicationCaution
Does not bind calcium as one of the calcium-binding sites is lost (Asp->Arg in position 48, which corresponds to 'Arg-49' in the current nomenclature).Curated
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: InterPro
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Myotoxin, Toxin |
Enzyme and pathway databases
BRENDAi | 3.1.1.4, 9394 |
Names & Taxonomyi
Protein namesi | Recommended name: Basic phospholipase A2 homolog zhaoermiatoxinShort name: svPLA2 homolog |
Organismi | Protobothrops mangshanensis (Mangshan pitviper) (Zhaoermia mangshanensis) |
Taxonomic identifieri | 242058 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Protobothrops |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is in the range of 6.25-12.5 mg/kg by intraperitoneal injection into mice.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250615 | 1 – 121 | Basic phospholipase A2 homolog zhaoermiatoxinAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 115 | 1 Publication | ||
Disulfide bondi | 28 ↔ 44 | 1 Publication | ||
Disulfide bondi | 43 ↔ 95 | 1 Publication | ||
Disulfide bondi | 49 ↔ 121 | 1 Publication | ||
Disulfide bondi | 50 ↔ 88 | 1 Publication | ||
Disulfide bondi | 57 ↔ 81 | 1 Publication | ||
Disulfide bondi | 75 ↔ 86 | 1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
PRIDEi | P84776 |
Expressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Interactioni
Subunit structurei
Homodimer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P84776 |
SMRi | P84776 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P84776 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
P84776-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SLIELTKMVF QETGKNPVTY YTLYGCNCGV GRRGKPKDAT DRCCFVHRCC
60 70 80 90 100
YKKLTGCDPK KDRYSYSWEN KAIVCGEKNP CLKELCECDK AVAICLRKNL
110 120
GTYDKNYRFT MKFLCDKPEK C
Mass spectrometryi
Molecular mass is 13972.0 Da. Determined by ESI. 1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PH4 | X-ray | 2.05 | A/B | 1-121 | [»] | |
AlphaFoldDBi | P84776 | |||||
SMRi | P84776 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | P84776 |
Enzyme and pathway databases
BRENDAi | 3.1.1.4, 9394 |
Miscellaneous databases
EvolutionaryTracei | P84776 |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2H_PROMB | |
Accessioni | P84776Primary (citable) accession number: P84776 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | May 25, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families