UniProtKB - P84744 (KAX95_BUTOC)
Protein
Potassium channel toxin alpha-KTx 9.5
Gene
N/A
Organism
Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Status
Functioni
Binds and inhibits voltage-gated potassium channels, with varying affinities for Kv1.2/KCNA2 > Kv1.3/KCNA3 > Kv1.1/KCNA1. Also inhibits calcium-activated potassium channels (KCa/KCNN).1 Publication
GO - Molecular functioni
- potassium channel inhibitor activity Source: UniProtKB
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- negative regulation of potassium ion transport Source: UniProtKB
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 9.5Alternative name(s): Neurotoxin Kbot1 |
Organismi | Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus) |
Taxonomic identifieri | 6871 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Buthus › |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000045198 | 1 – 28 | Potassium channel toxin alpha-KTx 9.5Add BLAST | 28 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 19 | By similarity | ||
Disulfide bondi | 6 ↔ 24 | By similarity | ||
Disulfide bondi | 10 ↔ 26 | By similarity | ||
Modified residuei | 28 | Valine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
3D structure databases
ProteinModelPortali | P84744 |
SMRi | P84744 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 09 subfamily.Curated
Family and domain databases
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR008911 Toxin_alpha-KTx_8/9 |
Pfami | View protein in Pfam PF05453 Toxin_6, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P84744 |
SMRi | P84744 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR008911 Toxin_alpha-KTx_8/9 |
Pfami | View protein in Pfam PF05453 Toxin_6, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KAX95_BUTOC | |
Accessioni | P84744Primary (citable) accession number: P84744 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | December 5, 2018 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families