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Protein

Conotoxin de13a

Gene
N/A
Organism
Conus delessertii (Sozon's cone) (Conus sozoni)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin de13a
OrganismiConus delessertii (Sozon's cone) (Conus sozoni)
Taxonomic identifieri348592 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConasprellaConasprella incertae sedis

Organism-specific databases

ConoServeri1500 De13a precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000426831 – 32Conotoxin de13aAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34-hydroxyproline1 Publication1
Modified residuei74-hydroxyproline1 Publication1
Modified residuei146'-bromotryptophan1 Publication1
Modified residuei185-hydroxylysine1 Publication1
Modified residuei214-hydroxyproline1 Publication1
Modified residuei255-hydroxylysine1 Publication1
Modified residuei32Histidine amide1 Publication1

Post-translational modificationi

Contains 4 disulfide bonds.
The diastereomeric form of 5-hydroxylysine found was not conclusively established, but it is probably 5R.

Keywords - PTMi

Amidation, Bromination, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Domaini

The cysteine framework is XIII (C-C-C-CC-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin G superfamily.Curated

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84698-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
DCPTRCPTTC ANGWECCKGY PCVNKACSGC THGK
Length:34
Mass (Da):3,595
Last modified:October 25, 2005 - v1
Checksum:iF58FD10670E9CC0D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5R → S AA sequence (PubMed:16101297).Curated1

Mass spectrometryi

Molecular mass is 3486.76 Da from positions 1 - 32. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1500 De13a precursor

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCDA_CONDE
AccessioniPrimary (citable) accession number: P84698
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: September 12, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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