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Protein

Circulin-F

Gene
N/A
Organism
Chassalia parviflora
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus.PROSITE-ProRule annotationCurated1 Publication

Caution

This peptide is cyclic. The start position was chosen by similarity to OAK1 (kalata-B1) for which the DNA sequence is known.Curated

GO - Biological processi

  • defense response Source: UniProtKB
  • regulation of defense response to virus Source: UniProtKB-KW

Keywordsi

Molecular functionAntiviral protein
Biological processPlant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Circulin-F
Short name:
CIRF
OrganismiChassalia parviflora
Taxonomic identifieri58431 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesRubiaceaeRubioideaePalicoureeaeChassalia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000436031 – 29Circulin-FPROSITE-ProRule annotation1 PublicationAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki1 ↔ 29Cyclopeptide (Ala-Arg)1 Publication
Disulfide bondi4 ↔ 20PROSITE-ProRule annotationBy similarity
Disulfide bondi8 ↔ 22PROSITE-ProRule annotationBy similarity
Disulfide bondi13 ↔ 27PROSITE-ProRule annotationBy similarity

Post-translational modificationi

This is a cyclic peptide.PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP84644
SMRiP84644
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the cyclotide family. Bracelet subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR005535 Cyclotide
IPR012323 Cyclotide_bracelet_CS
IPR036146 Cyclotide_sf
PfamiView protein in Pfam
PF03784 Cyclotide, 1 hit
PIRSFiPIRSF037891 Cycloviolacin, 1 hit
SUPFAMiSSF57038 SSF57038, 1 hit
PROSITEiView protein in PROSITE
PS51052 CYCLOTIDE, 1 hit
PS60008 CYCLOTIDE_BRACELET, 1 hit

Sequencei

Sequence statusi: Complete.

P84644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
AIPCGESCVW IPCISAAIGC SCKNKVCYR
Length:29
Mass (Da):3,076
Last modified:September 13, 2005 - v1
Checksum:i019A52EACB38A95D
GO

Mass spectrometryi

Molecular mass is 3053.2 Da from positions 1 - 29. Determined by FAB. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiCIRF_CHAPA
AccessioniPrimary (citable) accession number: P84644
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 25, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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