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Entry version 112 (11 Dec 2019)
Sequence version 1 (21 Jun 2005)
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Protein

SKI family transcriptional corepressor 1

Gene

Skor1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits BMP signaling. Acts as a transcriptional corepressor of LBX1 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SKI family transcriptional corepressor 1
Alternative name(s):
Ladybird homeobox corepressor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Skor1
Synonyms:Lbxcor1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1307687 Skor1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001293921 – 964SKI family transcriptional corepressor 1Add BLAST964

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P84551

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P84551

PRoteomics IDEntifications database

More...
PRIDEi
P84551

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P84551

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P84551

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000013959 Expressed in 2 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P84551 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LBX1.

Interacts with SMAD1, SMAD2 and SMAD3 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000018756

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P84551

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili857 – 921Sequence analysisAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKI family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEFD Eukaryota
ENOG410XPY0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158440

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P84551

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRSISPD

Database of Orthologous Groups

More...
OrthoDBi
1034068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P84551

TreeFam database of animal gene trees

More...
TreeFami
TF324133

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.260.20, 1 hit
3.10.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR028762 SKOR1
IPR023216 Tscrpt_reg_SKI_SnoN

The PANTHER Classification System

More...
PANTHERi
PTHR10005 PTHR10005, 1 hit
PTHR10005:SF8 PTHR10005:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P84551-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLCGLGQV TLRLWVSLPF QTENRIGFLA AGAFLRSGGM EALTTQLGPG
60 70 80 90 100
REGSSSPNSK QELQPYSGSS ALKPNQVGET SLYGVPIVSL VIDGQERLCL
110 120 130 140 150
AQISNTLLKN YSYNEIHNRR VALGITCVQC TPVQLEILRR AGAMPISSRR
160 170 180 190 200
CGMITKREAE RLCKSFLGEH KPPKLPENFA FDVVHECAWG SRGSFIPARY
210 220 230 240 250
NSSRAKCIKC GYCSMYFSPN KFIFHSHRTP DAKYTQPDAA NFNSWRRHLK
260 270 280 290 300
LSDKSATDEL SHAWEDVKAM FNGGTRKRTF SLQGGGGGGA NSGSGGAGKG
310 320 330 340 350
GAGGGGGPGC GSEMAPGPPP HKSLRCGEDE ASGPPGPPPP HPQRALGLAA
360 370 380 390 400
AANGPAGPGG PGGSAGVRSY PVIPVPSKGF GLLQKLPPPL FPHPYGFPTA
410 420 430 440 450
FGLCPKKDDP VLVAGEPKGG PGTGSGGGAG TAAGAGGPGA GHLPPGAGPG
460 470 480 490 500
PGGGTMFWGH QPSGAAKDAA AVAAAAAAAT VYPTFPMFWP AAGSLPVPPY
510 520 530 540 550
PAAQSQAKAV AAAVAAAAAA AAAAAGGGGP ESLDGAEPAK EGSLGTEERC
560 570 580 590 600
PSALSRGPLD EDGADEALPP SLAPLAPPPP PPARKSSYVS AFRPVVKDAE
610 620 630 640 650
SIAKLYGSAR EAYGSGPARG PVPGTGTGGG YVSPDFLSEG SSSYHSASPD
660 670 680 690 700
VDTADEPEVD VESNRFPDEE GAQEDTEPSV PSTGGGPDGD QPAGPPSVTS
710 720 730 740 750
SGADGPTDSA DGDSPRPRRR LGPPPAIRSA FGDLVADDVV RRTERSPPNG
760 770 780 790 800
GYELREPCGP LGGPAAAKVY VPERDEHVKS AAAAAALGPA ASYLCTPETH
810 820 830 840 850
EPDKEDNHST TADDLETRKS FSDQRSVSQP SPANTDRGED GLTLDVTGTQ
860 870 880 890 900
LVEKDIENLA REELQKLLLE QMELRKKLER EFQSLKDNFQ DQMKRELAYR
910 920 930 940 950
EEMVQQLQIV RDTLCNELDQ ERKARYAIQQ KLKEAHDALH HFSCKMLTPR
960
HCTGNCSFKP PLLP
Length:964
Mass (Da):100,234
Last modified:June 21, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78D1B922CAB29B7D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR03062264 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006226487.2, XM_006226425.2
XP_006243308.2, XM_006243246.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000018756; ENSRNOP00000018756; ENSRNOG00000013959

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315748

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:315748

UCSC genome browser

More...
UCSCi
RGD:1307687 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03062264 Genomic DNA No translation available.
RefSeqiXP_006226487.2, XM_006226425.2
XP_006243308.2, XM_006243246.2

3D structure databases

SMRiP84551
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018756

PTM databases

iPTMnetiP84551
PhosphoSitePlusiP84551

Proteomic databases

jPOSTiP84551
PaxDbiP84551
PRIDEiP84551

Genome annotation databases

EnsembliENSRNOT00000018756; ENSRNOP00000018756; ENSRNOG00000013959
GeneIDi315748
KEGGirno:315748
UCSCiRGD:1307687 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
390598
RGDi1307687 Skor1

Phylogenomic databases

eggNOGiENOG410IEFD Eukaryota
ENOG410XPY0 LUCA
GeneTreeiENSGT00940000158440
InParanoidiP84551
OMAiYRSISPD
OrthoDBi1034068at2759
PhylomeDBiP84551
TreeFamiTF324133

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P84551

Gene expression databases

BgeeiENSRNOG00000013959 Expressed in 2 organ(s), highest expression level in testis
GenevisibleiP84551 RN

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR028762 SKOR1
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PTHR10005:SF8 PTHR10005:SF8, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKOR1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P84551
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: December 11, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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