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Entry version 130 (07 Oct 2020)
Sequence version 1 (21 Jun 2005)
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Protein

SKI family transcriptional corepressor 1

Gene

SKOR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P84550

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P84550

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SKI family transcriptional corepressor 1
Alternative name(s):
Functional Smad-suppressing element on chromosome 15
Short name:
Fussel-15
LBX1 corepressor 1
Ladybird homeobox corepressor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SKOR1
Synonyms:CORL1, FUSSEL15, LBXCOR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188779.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21326, SKOR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611273, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P84550

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000188779

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165479509

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P84550, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SKOR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68052265

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001293901 – 965SKI family transcriptional corepressor 1Add BLAST965

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P84550

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P84550

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P84550

PeptideAtlas

More...
PeptideAtlasi
P84550

PRoteomics IDEntifications database

More...
PRIDEi
P84550

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57758 [P84550-1]
57759 [P84550-2]
57760 [P84550-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P84550

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P84550

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present specifically in cerebellar Purkinje cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188779, Expressed in cerebellum and 86 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P84550, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188779, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LBX1 (By similarity).

Interacts with SMAD1, SMAD2 and SMAD3.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P84550, 1 interactor

Molecular INTeraction database

More...
MINTi
P84550

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343200

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P84550, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P84550

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili858 – 922Sequence analysisAdd BLAST65

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKI family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQC2, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158440

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011930_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P84550

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAKVYAP

Database of Orthologous Groups

More...
OrthoDBi
1034068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P84550

TreeFam database of animal gene trees

More...
TreeFami
TF324133

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.260.20, 1 hit
3.10.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014890, c-SKI_SMAD4-bd_dom
IPR009061, DNA-bd_dom_put_sf
IPR010919, SAND-like_dom_sf
IPR003380, SKI/SNO/DAC
IPR037000, Ski_DNA-bd_sf
IPR028762, SKOR1
IPR023216, Tscrpt_reg_SKI_SnoN

The PANTHER Classification System

More...
PANTHERi
PTHR10005, PTHR10005, 1 hit
PTHR10005:SF8, PTHR10005:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08782, c-SKI_SMAD_bind, 1 hit
PF02437, Ski_Sno, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01046, c-SKI_SMAD_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955, SSF46955, 1 hit
SSF63763, SSF63763, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P84550-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLCGLGQV TLRIWVSLPS QSENGIGFLA ARAFLRSGGM EALTTQLGPG
60 70 80 90 100
REGSSSPNSK QELQPYSGSS ALKPNQVGET SLYGVPIVSL VIDGQERLCL
110 120 130 140 150
AQISNTLLKN YSYNEIHNRR VALGITCVQC TPVQLEILRR AGAMPISSRR
160 170 180 190 200
CGMITKREAE RLCKSFLGEH KPPKLPENFA FDVVHECAWG SRGSFIPARY
210 220 230 240 250
NSSRAKCIKC GYCSMYFSPN KFIFHSHRTP DAKYTQPDAA NFNSWRRHLK
260 270 280 290 300
LSDKSATDEL SHAWEDVKAM FNGGTRKRTF SLQGGGGGGA NGGSGGQGKG
310 320 330 340 350
GAGGGGGGGP GCGAEMAPGP PPHKSLRCGE DEAAGPPGPP PPHPQRGLGL
360 370 380 390 400
ATGASGPAGP GGPGGGAGVR SYPVIPVPSK GFGLLQKLPP PLFPHPYGFP
410 420 430 440 450
TAFGLCPKKD DPVLGAGEPK GGPGTGSGGG GAGTGGGAGG PGASHLPPGA
460 470 480 490 500
GAGPGGGAMF WGHQPSGAAK DAAAVAAAAA AATVYPTFPM FWPAAGSLPV
510 520 530 540 550
PSYPAAQSQA KAVAAAVAAA AAAAAAAAGS GAPEPLDGAE PAKESGLGAE
560 570 580 590 600
ERCPSALSRG PLDEDGTDEA LPPPLAPLPP PPPPPARKGS YVSAFRPVVK
610 620 630 640 650
DTESIAKLYG SAREAYGAGP ARGPGPGAGS GGYVSPDFLS EGSSSYNSAS
660 670 680 690 700
PDVDTADEPE VDVESNRFPD DEDAQEETEP SAPSAGGGPD GEQPTGPPSA
710 720 730 740 750
TSSGADGPAN SPDGGSPRPR RRLGPPPAGR PAFGDLAAED LVRRPERSPP
760 770 780 790 800
SGGGGYELRE PCGPLGGPAP AKVFAPERDE HVKSAAVALG PAASYVCTPE
810 820 830 840 850
AHEPDKEDNH SPADDLETRK SYPDQRSISQ PSPANTDRGE DGLTLDVTGT
860 870 880 890 900
HLVEKDIENL AREELQKLLL EQMELRKKLE REFQSLKDNF QDQMKRELAY
910 920 930 940 950
REEMVQQLQI VRDTLCNELD QERKARYAIQ QKLKEAHDAL HHFSCKMLTP
960
RHCTGNCSFK PPLLP
Length:965
Mass (Da):99,831
Last modified:June 21, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i313E95B0430A979B
GO
Isoform 2 (identifier: P84550-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MALLCGLGQV...GFLAARAFLR → MIPKSLVQAA...HVDLGGNQLW
     267-345: Missing.
     422-588: Missing.
     691-727: Missing.

Show »
Length:868
Mass (Da):93,779
Checksum:iA206B5ADFF8E8421
GO
Isoform 3 (identifier: P84550-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-36: Missing.
     277-311: Missing.

Show »
Length:921
Mass (Da):96,028
Checksum:i52DBF87B6324D49F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3E1G3V3E1_HUMAN
SKI family transcriptional corepres...
SKOR1
926Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5H7G3V5H7_HUMAN
SKI family transcriptional corepres...
SKOR1
937Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07927273K → Q1 PublicationCorresponds to variant dbSNP:rs776369126Ensembl.1
Isoform 2 (identifier: P84550-2)
Natural variantiVAR_08291627R → T1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0336781 – 36MALLC…RAFLR → MIPKSLVQAAETQRGLCEPG GKGREGRSGGKGETRPRGVG TQEGKGTIPGSPREKRGERG EGDPALLPAEDLWRLPGSKD RLRSSLLPPPGPPSSDSGPG PPSSHSGKTAQGPRTLNWAR KQSARTSSNLCAWSLAMATK MAEIPSSPYEPGQRGMKDTQ RGDAPQRGSPEPRILQLARV GNVYLKEESSRSGRLEAKKW IPTKFLENLSVPHVDLGGNQ LW in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_04019928 – 36Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_033679267 – 345Missing in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_040200277 – 311Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_033680422 – 588Missing in isoform 2. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_033681691 – 727Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY669507 mRNA Translation: AAV74188.1
AC009292 Genomic DNA No translation available.
BC168376 mRNA Translation: AAI68376.1

NCBI Reference Sequences

More...
RefSeqi
NP_001244953.1, NM_001258024.1
XP_016877662.1, XM_017022173.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341418; ENSP00000343200; ENSG00000188779 [P84550-2]
ENST00000380035; ENSP00000369374; ENSG00000188779 [P84550-1]

UCSC genome browser

More...
UCSCi
uc031qsn.2, human [P84550-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669507 mRNA Translation: AAV74188.1
AC009292 Genomic DNA No translation available.
BC168376 mRNA Translation: AAI68376.1
RefSeqiNP_001244953.1, NM_001258024.1
XP_016877662.1, XM_017022173.1

3D structure databases

SMRiP84550
ModBaseiSearch...

Protein-protein interaction databases

IntActiP84550, 1 interactor
MINTiP84550
STRINGi9606.ENSP00000343200

PTM databases

iPTMnetiP84550
PhosphoSitePlusiP84550

Polymorphism and mutation databases

BioMutaiSKOR1
DMDMi68052265

Proteomic databases

jPOSTiP84550
MassIVEiP84550
PaxDbiP84550
PeptideAtlasiP84550
PRIDEiP84550
ProteomicsDBi57758 [P84550-1]
57759 [P84550-2]
57760 [P84550-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50926, 22 antibodies

The DNASU plasmid repository

More...
DNASUi
390598

Genome annotation databases

EnsembliENST00000341418; ENSP00000343200; ENSG00000188779 [P84550-2]
ENST00000380035; ENSP00000369374; ENSG00000188779 [P84550-1]
UCSCiuc031qsn.2, human [P84550-1]

Organism-specific databases

EuPathDBiHostDB:ENSG00000188779.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SKOR1
HGNCiHGNC:21326, SKOR1
HPAiENSG00000188779, Tissue enriched (brain)
MIMi611273, gene
neXtProtiNX_P84550
OpenTargetsiENSG00000188779
PharmGKBiPA165479509

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQC2, Eukaryota
GeneTreeiENSGT00940000158440
HOGENOMiCLU_011930_1_1_1
InParanoidiP84550
OMAiTAKVYAP
OrthoDBi1034068at2759
PhylomeDBiP84550
TreeFamiTF324133

Enzyme and pathway databases

PathwayCommonsiP84550
SIGNORiP84550

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
390598, 3 hits in 872 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
390598
PharosiP84550, Tbio

Protein Ontology

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PROi
PR:P84550
RNActiP84550, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000188779, Expressed in cerebellum and 86 other tissues
ExpressionAtlasiP84550, baseline and differential

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890, c-SKI_SMAD4-bd_dom
IPR009061, DNA-bd_dom_put_sf
IPR010919, SAND-like_dom_sf
IPR003380, SKI/SNO/DAC
IPR037000, Ski_DNA-bd_sf
IPR028762, SKOR1
IPR023216, Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005, PTHR10005, 1 hit
PTHR10005:SF8, PTHR10005:SF8, 1 hit
PfamiView protein in Pfam
PF08782, c-SKI_SMAD_bind, 1 hit
PF02437, Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046, c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955, SSF46955, 1 hit
SSF63763, SSF63763, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKOR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P84550
Secondary accession number(s): A6NIP4, A6NJY0, Q2VWA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: October 7, 2020
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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