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Protein

Kiwellin

Gene
N/A
Organism
Actinidia deliciosa (Kiwi)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kissper is an anion-selective pore-forming peptide.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Kiwellin
Alternative name(s):
Allergen: Act d 5
Cleaved into the following 4 chains:
OrganismiActinidia deliciosa (Kiwi)
Taxonomic identifieri3627 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridsEricalesActinidiaceaeActinidia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE from the serum of kiwi-allergic patients.2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei2821 Act d 5
3588 Act d 5.0101

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000833961 – 189KiwellinAdd BLAST189
PeptideiPRO_00003187671 – 39Kissper2 PublicationsAdd BLAST39
ChainiPRO_000034124638 – 189KiTH-31 PublicationAdd BLAST152
ChainiPRO_000034124740 – 189KiTH-11 PublicationAdd BLAST150
ChainiPRO_000034124842 – 189KiTH-21 PublicationAdd BLAST148

Post-translational modificationi

Undergoes proteolytic cleavage by actinidin to produce kissper and KiTH. Three forms of KiTH are produced by cleavage at different sites, the main form produced in vivo is KiTH-1.1 Publication

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP84527
SMRiP84527
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kiwellin family.Curated

Family and domain databases

Gene3Di2.40.40.10, 1 hit
InterProiView protein in InterPro
IPR039271 Kiwellin-like
IPR036908 RlpA-like_sf
PANTHERiPTHR33191 PTHR33191, 1 hit
SUPFAMiSSF50685 SSF50685, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84527-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ISSCNGPCRD LNDCDGQLIC IKGKCNDDPQ VGTHICRGTT HSHQPGGCKP
60 70 80 90 100
SGTLTCRGKS YPTYDCSPPV TSSTPAKLTN NDFSEGGDDG GPSECDESYH
110 120 130 140 150
NNNERIVALS TGWYNGGSRC GKMIRITASN GKSVSAKVVD ECDSRHGCDK
160 170 180
EHAGQPPCRN NIVDGSNAVW SALGLDKNVG VVDITWSMA
Length:189
Mass (Da):19,968
Last modified:January 24, 2006 - v1
Checksum:i731EC308E13E1104
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti61Y → H1 Publication1

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X9UX-ray2.10A/B1-189[»]
ProteinModelPortaliP84527
SMRiP84527
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2821 Act d 5
3588 Act d 5.0101

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.40.10, 1 hit
InterProiView protein in InterPro
IPR039271 Kiwellin-like
IPR036908 RlpA-like_sf
PANTHERiPTHR33191 PTHR33191, 1 hit
SUPFAMiSSF50685 SSF50685, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIWEL_ACTDE
AccessioniPrimary (citable) accession number: P84527
Secondary accession number(s): P83975, P83976
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 18, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Allergens
    Nomenclature of allergens and list of entries
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