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UniProtKB - P84445 (ICP0_EHV1V)
Protein
E3 ubiquitin-protein ligase ICP0
Gene
ICP0
Organism
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)
Status
Functioni
Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100.
By similarityCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 8 | Zinc 1By similarity | 1 | |
Metal bindingi | 11 | Zinc 1By similarity | 1 | |
Metal bindingi | 24 | Zinc 2By similarity | 1 | |
Metal bindingi | 26 | Zinc 2By similarity | 1 | |
Metal bindingi | 29 | Zinc 1By similarity | 1 | |
Metal bindingi | 32 | Zinc 1By similarity | 1 | |
Metal bindingi | 43 | Zinc 2By similarity | 1 | |
Metal bindingi | 46 | Zinc 2By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 8 – 47 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- disruption by symbiont of host cell PML body Source: UniProtKB
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host exit from mitosis Source: UniProtKB-KW
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase ICP0 (EC:2.3.2.27)Alternative name(s): Infected cell protein 0 RING-type E3 ubiquitin transferase ICP0Curated |
Gene namesi | Name:ICP0 |
Organismi | Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus) |
Taxonomic identifieri | 310273 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › |
Virus hosti | Equus caballus (Horse) [TaxID: 9796] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056355 | 1 – 532 | E3 ubiquitin-protein ligase ICP0Add BLAST | 532 |
Post-translational modificationi
Auto-ubiquitinated.By similarity
Keywords - PTMi
Ubl conjugationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 206 – 391 | DisorderedSequence analysisAdd BLAST | 186 | |
Regioni | 406 – 426 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 461 – 498 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 510 – 532 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 219 – 241 | Acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 265 – 279 | Basic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 347 – 361 | Polar residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 8 – 47 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00097, zf-C3HC4, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P84445-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATVAERCPI CLEDPSNYSM ALPCLHAFCY VCITRWIRQN PTCPLCKVPV
60 70 80 90 100
ESVVHTIESD SEFKETKVSV DFDYDSEEDE DSFEGQFLAV DSGDAPANIS
110 120 130 140 150
AWNGPMAFVP LNANGTAGAP RLQPLVDWLV ERLDQLFETP ELALVMRNIV
160 170 180 190 200
MDTLCEHGCN EEELTRQFWP MFHEDTVPFV TDLIVQAELC VASRPILPIA
210 220 230 240 250
RGRGVEYIDS SSSSSSSEEE TDSDIEVDPN NLTDPEDTSD ETSTDNSSAQ
260 270 280 290 300
APRQEDSRPA RARPGPPTRG RRRGRRPAAP GPASRRSARL RRRQPRTNSR
310 320 330 340 350
TNGGDNGEII DLTLDSDGDT EPADVSGSLN TTDQPVLIPD EEEAAPASPH
360 370 380 390 400
TSSNSAIICL VSELTPESEE PPRDQPVAPS GSSAGERPMR PRCSLREFAR
410 420 430 440 450
RFMALAPRDS STSEAAGPSR LGAGPRATEP FSVAVVLVDR SSEGAGLFGG
460 470 480 490 500
RFAQHVRRRT EDESARRRGN VLLRPRRQSV PPVPYPDIAS TSPLIRQGGQ
510 520 530
RVRDLQRAFQ TQPAEPEEMR CPHNCQRYRR NQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY464052 Genomic DNA Translation: AAS45947.1 |
RefSeqi | YP_053107.1, NC_001491.2 |
Genome annotation databases
GeneIDi | 2948570 |
KEGGi | vg:2948570 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY464052 Genomic DNA Translation: AAS45947.1 |
RefSeqi | YP_053107.1, NC_001491.2 |
3D structure databases
SMRi | P84445 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 2948570 |
KEGGi | vg:2948570 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00097, zf-C3HC4, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ICP0_EHV1V | |
Accessioni | P84445Primary (citable) accession number: P84445 Secondary accession number(s): Q6S6U1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | March 1, 2005 | |
Last modified: | February 23, 2022 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |