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Protein

Serine/threonine-protein kinase UL13 homolog

Gene

49

Organism
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression. Regulates the nuclear localization of viral envelopment factors UL34 and UL31 homologs, by phosphorylating the US3 kinase homolog, indicating a role in nuclear egress. Disrupts host nuclear lamins, including LMNA and LMNB1. Phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of glycoprotein E (gE) by UL13 homolog alters its subcellular localization, from the host early endosome to the plasma membrane. Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator ICP22 homolog (By similarity).By similarity

Miscellaneous

Displays a substrate specificity similar to host CDC2.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPPROSITE-ProRule annotationBy similarity1
Active sitei349Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi229 – 237ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase UL13 homolog (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:49
OrganismiEquine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)
Taxonomic identifieri310273 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000008296 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861861 – 594Serine/threonine-protein kinase UL13 homologAdd BLAST594

Post-translational modificationi

Autophosphorylated.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 594Protein kinasePROSITE-ProRule annotationAdd BLAST372

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi482 – 485Poly-Tyr4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

OrthoDBiVOG09000040

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P84391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSRRRSSV DEMDVGGSAT SEYENCGGPS FSPLNLSRPK KSTRGRSLRS
60 70 80 90 100
AQAWGGKQLH PERSTPLARN DCGPSSKPRR RHEVGRSNKG LGASLDRTDE
110 120 130 140 150
DTSQCPRIRA SAIRCGASTR KIVRITGECD AQQGDSRPGR SEMAGWHSPP
160 170 180 190 200
KRRRTPSRHG NSDNERSHLP RLSSHGVVRV GGRPLTQTPL QKTIILQPKL
210 220 230 240 250
VRKVFMPTFT VNPEMHYRRV ALGEIPKFGG AGSYGEVQIF KQTGLAIKTA
260 270 280 290 300
SSRSCFEHEL AVSLLTGECS LRAQASLGIG GIICLMAFSL PSKQMVFPAY
310 320 330 340 350
DADLNAYGYR LSRSGPPSVL VTESIERAFI GLGRALVYLN TSCGLTHLDV
360 370 380 390 400
KGGNIFVNHS HFVISDCVIG DLSLMTLNTN SMAMRAEFEI DTGEEEIKTL
410 420 430 440 450
RLPRSASQMT FSFVIGHGLN QPISVIADFI NNSGLAKSTG PIKHDVGLTI
460 470 480 490 500
DLYALGQALL ELLLVGCISP CLSVPILRTA TYYYYSNKLS VDYALDLLAY
510 520 530 540 550
RCSLYPALFP TTPLTTIYGI PWDQVEGVFE SIAGAHHREA FRAHLERYRL
560 570 580 590
THRRLFASIR IPSAFTGVLE LVSLLCHANE KARLSIPLLW TPRP
Length:594
Mass (Da):65,248
Last modified:February 15, 2005 - v1
Checksum:i5A69A541897061CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY464052 Genomic DNA Translation: AAS45933.1
RefSeqiYP_053094.1, NC_001491.2

Genome annotation databases

GeneIDi1487528
KEGGivg:1487528

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY464052 Genomic DNA Translation: AAS45933.1
RefSeqiYP_053094.1, NC_001491.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1487528
KEGGivg:1487528

Phylogenomic databases

OrthoDBiVOG09000040

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUL13_EHV1V
AccessioniPrimary (citable) accession number: P84391
Secondary accession number(s): Q6S6S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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