UniProtKB - P84245 (H33_RAT)
Protein
Histone H3.3
Gene
H3-3b
Organism
Rattus norvegicus (Rat)
Status
Functioni
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.By similarity
GO - Molecular functioni
- nucleosomal DNA binding Source: RGD
- protein heterodimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II core promoter sequence-specific DNA binding Source: RGD
GO - Biological processi
- brain development Source: RGD
- cell population proliferation Source: RGD
- DNA replication-independent nucleosome assembly Source: RGD
- embryo implantation Source: RGD
- male gonad development Source: RGD
- multicellular organism growth Source: RGD
- muscle cell differentiation Source: RGD
- negative regulation of chromosome condensation Source: RGD
- nucleosome assembly Source: RGD
- nucleus organization Source: RGD
- oogenesis Source: RGD
- osteoblast differentiation Source: RGD
- pericentric heterochromatin assembly Source: RGD
- positive regulation of cell growth Source: RGD
- regulation of centromere complex assembly Source: RGD
- response to hormone Source: RGD
- single fertilization Source: RGD
- spermatid development Source: RGD
- spermatogenesis Source: RGD
- subtelomeric heterochromatin assembly Source: RGD
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-RNO-201722, Formation of the beta-catenin:TCF transactivating complex R-RNO-212300, PRC2 methylates histones and DNA R-RNO-2299718, Condensation of Prophase Chromosomes R-RNO-2559580, Oxidative Stress Induced Senescence R-RNO-2559582, Senescence-Associated Secretory Phenotype (SASP) R-RNO-427359, SIRT1 negatively regulates rRNA expression R-RNO-427413, NoRC negatively regulates rRNA expression R-RNO-5250924, B-WICH complex positively regulates rRNA expression R-RNO-5578749, Transcriptional regulation by small RNAs R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-RNO-73728, RNA Polymerase I Promoter Opening R-RNO-73772, RNA Polymerase I Promoter Escape R-RNO-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-RNO-9018519, Estrogen-dependent gene expression R-RNO-9670095, Inhibition of DNA recombination at telomere R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H3.3 |
Gene namesi | Name:H3-3bBy similarity Synonyms:H3.3b, H3f3bImported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621095, H3f3b |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Nucleus
- Barr body Source: Ensembl
- nuclear chromosome Source: RGD
- nuclear chromosome, telomeric region Source: RGD
- nuclear nucleosome Source: RGD
- nucleus Source: RGD
Other locations
- nucleosome Source: RGD
- protein-containing complex Source: RGD
Keywords - Cellular componenti
Chromosome, Nucleosome core, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCurated | |||
ChainiPRO_0000221254 | 2 – 136 | Histone H3.3Add BLAST | 135 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | Asymmetric dimethylarginine; by PRMT6; alternateBy similarity | 1 | |
Modified residuei | 3 | Citrulline; alternateBy similarity | 1 | |
Modified residuei | 4 | Phosphothreonine; by HASPINBy similarity | 1 | |
Modified residuei | 5 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 5 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 5 | N6,N6-dimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 5 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 5 | N6-(beta-hydroxybutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 5 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 5 | N6-crotonyllysine; alternateBy similarity | 1 | |
Modified residuei | 5 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 7 | Phosphothreonine; by PKCBy similarity | 1 | |
Modified residuei | 9 | Citrulline; alternateBy similarity | 1 | |
Modified residuei | 9 | Symmetric dimethylarginine; by PRMT5; alternateBy similarity | 1 | |
Modified residuei | 10 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 10 | N6,N6-dimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 10 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 10 | N6-(beta-hydroxybutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 10 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 10 | N6-crotonyllysine; alternateBy similarity | 1 | |
Modified residuei | 10 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 11 | ADP-ribosylserine; alternateBy similarity | 1 | |
Modified residuei | 11 | Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA51 Publication | 1 | |
Modified residuei | 12 | Phosphothreonine; by PKC1 Publication | 1 | |
Modified residuei | 15 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 15 | N6-(beta-hydroxybutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 15 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 15 | N6-glutaryllysine; alternateBy similarity | 1 | |
Modified residuei | 15 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 18 | Asymmetric dimethylarginine; by CARM1; alternateBy similarity | 1 | |
Modified residuei | 18 | Citrulline; alternateBy similarity | 1 | |
Modified residuei | 19 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 19 | N6-(beta-hydroxybutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 19 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 19 | N6-butyryllysine; alternateBy similarity | 1 | |
Modified residuei | 19 | N6-crotonyllysine; alternateBy similarity | 1 | |
Modified residuei | 19 | N6-glutaryllysine; alternateBy similarity | 1 | |
Modified residuei | 19 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-(beta-hydroxybutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-butyryllysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-crotonyllysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-glutaryllysine; alternateBy similarity | 1 | |
Modified residuei | 24 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 27 | CitrullineBy similarity | 1 | |
Modified residuei | 28 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 28 | N6,N6-dimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 28 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 28 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 28 | N6-crotonyllysine; alternateBy similarity | 1 | |
Modified residuei | 28 | N6-glutaryllysine; alternateBy similarity | 1 | |
Modified residuei | 28 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 29 | ADP-ribosylserine; alternateBy similarity | 1 | |
Modified residuei | 29 | Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5By similarity | 1 | |
Modified residuei | 32 | PhosphoserineBy similarity | 1 | |
Modified residuei | 37 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 37 | N6,N6-dimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 37 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 37 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 37 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 38 | N6-methyllysineBy similarity | 1 | |
Modified residuei | 42 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 57 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 57 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 57 | N6-(beta-hydroxybutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 57 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 57 | N6-crotonyllysine; alternateBy similarity | 1 | |
Modified residuei | 57 | N6-glutaryllysine; alternateBy similarity | 1 | |
Modified residuei | 57 | N6-methyllysine; by EHMT2; alternateBy similarity | 1 | |
Modified residuei | 57 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 58 | PhosphoserineBy similarity | 1 | |
Modified residuei | 65 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 65 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 80 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 80 | N6,N6-dimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 80 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 80 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 80 | N6-glutaryllysine; alternateBy similarity | 1 | |
Modified residuei | 80 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 80 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 81 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 87 | PhosphoserineBy similarity | 1 | |
Modified residuei | 108 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 116 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 116 | N6-glutaryllysine; alternateBy similarity | 1 | |
Modified residuei | 123 | N6-(2-hydroxyisobutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 123 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 123 | N6-glutaryllysine; alternateBy similarity | 1 | |
Modified residuei | 123 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 123 | N6-succinyllysine; alternateBy similarity | 1 |
Post-translational modificationi
Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.By similarity
Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.By similarity
Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.By similarity
Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.By similarity
Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.By similarity
Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).By similarity1 Publication
Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.By similarity
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.By similarity
Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.By similarity
Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.By similarity
Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).By similarity
Keywords - PTMi
Acetylation, ADP-ribosylation, Citrullination, Hydroxylation, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P84245 |
PaxDbi | P84245 |
PRIDEi | P84245 |
PTM databases
iPTMneti | P84245 |
Expressioni
Developmental stagei
Expressed throughout the cell cycle independently of DNA synthesis. Levels increase from embryonic day 18 to postnatal day 10.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000003220, Expressed in thymus and 19 other tissues |
ExpressionAtlasi | P84245, baseline and differential |
Genevisiblei | P84245, RN |
Interactioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Interacts with HIRA, a chaperone required for its incorporation into nucleosomes.
Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 32 | Interaction with ZMYND11By similarity | 1 |
GO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 250653, 3 interactors |
IntActi | P84245, 1 interactor |
MINTi | P84245 |
STRINGi | 10116.ENSRNOP00000040434 |
Family & Domainsi
Domaini
Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).By similarity
Sequence similaritiesi
Belongs to the histone H3 family.Curated
Phylogenomic databases
eggNOGi | KOG1745, Eukaryota |
GeneTreei | ENSGT01010000222477 |
HOGENOMi | CLU_078295_4_0_1 |
InParanoidi | P84245 |
OMAi | CTMARTK |
OrthoDBi | 1564596at2759 |
PhylomeDBi | P84245 |
TreeFami | TF314241 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000164, Histone_H3/CENP-A |
PANTHERi | PTHR11426, PTHR11426, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00622, HISTONEH3 |
SMARTi | View protein in SMART SM00428, H3, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00322, HISTONE_H3_1, 1 hit PS00959, HISTONE_H3_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P84245-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARTKQTARK STGGKAPRKQ LATKAARKSA PSTGGVKKPH RYRPGTVALR
60 70 80 90 100
EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY
110 120 130
LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73683 mRNA Translation: CAA52035.1 BC063159 mRNA Translation: AAH63159.1 BC078759 mRNA Translation: AAH78759.1 BC086580 mRNA Translation: AAH86580.1 BC087725 mRNA Translation: AAH87725.1 |
PIRi | S34185 |
RefSeqi | NP_446437.1, NM_053985.2 XP_002728089.1, XM_002728043.3 XP_003752732.1, XM_003752684.4 |
Genome annotation databases
Ensembli | ENSRNOT00000004329; ENSRNOP00000004329; ENSRNOG00000003220 ENSRNOT00000050223; ENSRNOP00000040434; ENSRNOG00000006532 |
GeneIDi | 100361558 117056 |
KEGGi | rno:100361558 rno:117056 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73683 mRNA Translation: CAA52035.1 BC063159 mRNA Translation: AAH63159.1 BC078759 mRNA Translation: AAH78759.1 BC086580 mRNA Translation: AAH86580.1 BC087725 mRNA Translation: AAH87725.1 |
PIRi | S34185 |
RefSeqi | NP_446437.1, NM_053985.2 XP_002728089.1, XM_002728043.3 XP_003752732.1, XM_003752684.4 |
3D structure databases
SMRi | P84245 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 250653, 3 interactors |
IntActi | P84245, 1 interactor |
MINTi | P84245 |
STRINGi | 10116.ENSRNOP00000040434 |
PTM databases
iPTMneti | P84245 |
Proteomic databases
jPOSTi | P84245 |
PaxDbi | P84245 |
PRIDEi | P84245 |
Genome annotation databases
Ensembli | ENSRNOT00000004329; ENSRNOP00000004329; ENSRNOG00000003220 ENSRNOT00000050223; ENSRNOP00000040434; ENSRNOG00000006532 |
GeneIDi | 100361558 117056 |
KEGGi | rno:100361558 rno:117056 |
Organism-specific databases
CTDi | 15078 15081 |
RGDi | 621095, H3f3b |
Phylogenomic databases
eggNOGi | KOG1745, Eukaryota |
GeneTreei | ENSGT01010000222477 |
HOGENOMi | CLU_078295_4_0_1 |
InParanoidi | P84245 |
OMAi | CTMARTK |
OrthoDBi | 1564596at2759 |
PhylomeDBi | P84245 |
TreeFami | TF314241 |
Enzyme and pathway databases
Reactomei | R-RNO-201722, Formation of the beta-catenin:TCF transactivating complex R-RNO-212300, PRC2 methylates histones and DNA R-RNO-2299718, Condensation of Prophase Chromosomes R-RNO-2559580, Oxidative Stress Induced Senescence R-RNO-2559582, Senescence-Associated Secretory Phenotype (SASP) R-RNO-427359, SIRT1 negatively regulates rRNA expression R-RNO-427413, NoRC negatively regulates rRNA expression R-RNO-5250924, B-WICH complex positively regulates rRNA expression R-RNO-5578749, Transcriptional regulation by small RNAs R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-RNO-73728, RNA Polymerase I Promoter Opening R-RNO-73772, RNA Polymerase I Promoter Escape R-RNO-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-RNO-9018519, Estrogen-dependent gene expression R-RNO-9670095, Inhibition of DNA recombination at telomere R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
PROi | PR:P84245 |
Gene expression databases
Bgeei | ENSRNOG00000003220, Expressed in thymus and 19 other tissues |
ExpressionAtlasi | P84245, baseline and differential |
Genevisiblei | P84245, RN |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000164, Histone_H3/CENP-A |
PANTHERi | PTHR11426, PTHR11426, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00622, HISTONEH3 |
SMARTi | View protein in SMART SM00428, H3, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00322, HISTONE_H3_1, 1 hit PS00959, HISTONE_H3_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H33_RAT | |
Accessioni | P84245Primary (citable) accession number: P84245 Secondary accession number(s): P06351 Q9V3W4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families