Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hypotensin-2

Gene
N/A
Organism
Tityus serrulatus (Brazilian scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Agonist of the B2 bradykinin receptor (BDKRB2). Potentiates the hypotensive effect of bradykinin (BK) and induces a direct vasorelaxing effect, independently of BK, by endothelium- and nitric oxide (NO)-dependent mechanisms in rat aortic ring preparations. Does not inhibit the angiotensin-converting enzyme (ACE).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei23 – 24Important for potentiating BK effectsBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Hypotensive agent, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Hypotensin-21 Publication
Alternative name(s):
Hypotensin II1 Publication
Short name:
TsHpt-II1 Publication
Cleaved into the following chain:
Hypotensin-41 Publication
Alternative name(s):
Hypotensin IV1 Publication
Short name:
TsHpt-IV1 Publication
OrganismiTityus serrulatus (Brazilian scorpion)
Taxonomic identifieri6887 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002394341 – 25Hypotensin-21 PublicationAdd BLAST25
PeptideiPRO_00002394361 – 24Hypotensin-41 PublicationAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6Phosphoserine1 Publication1

Post-translational modificationi

The ultimate C-terminal Ala residue of TsHpt-I is quickly removed by carboxypeptidase Y in (in vitro) experiments.By similarity

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP84190

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
AEIDFSGIPE DIIKEIKETN AKPPA
Length:25
Mass (Da):2,726
Last modified:June 13, 2006 - v1
Checksum:i8D99F16FE445C0C6
GO

Mass spectrometryi

Molecular mass is 2725.6 Da from positions 1 - 25. Determined by ESI. 1 Publication
Molecular mass is 2654.6 Da from positions 1 - 24. Determined by ESI. 1 Publication

Entry informationi

Entry nameiNDBH2_TITSE
AccessioniPrimary (citable) accession number: P84190
Secondary accession number(s): P84192
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: February 28, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health