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Protein

Defensin ARD1

Gene
N/A
Organism
Archaeoprepona demophon (One-spotted leafwing butterfly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses potent anti-fungal activity.1 Publication

GO - Biological processi

  • antifungal humoral response Source: UniProtKB
  • defense response Source: UniProtKB
  • innate immune response Source: UniProtKB-KW
  • killing of cells of other organism Source: UniProtKB-KW

Keywordsi

Molecular functionAntimicrobial, Defensin, Fungicide
Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin ARD1
OrganismiArchaeoprepona demophon (One-spotted leafwing butterfly)
Taxonomic identifieri191427 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaPapilionoideaNymphalidaeCharaxinaePreponiniArchaeoprepona

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19N → R: Improves antifungal activity. 1 Publication1
Mutagenesisi36A → L: Improves antifungal activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000744761 – 44Defensin ARD1Add BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 32PROSITE-ProRule annotation1 Publication
Disulfide bondi18 ↔ 40PROSITE-ProRule annotation1 Publication
Disulfide bondi22 ↔ 42PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP84156
SMRiP84156
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84156

Family & Domainsi

Sequence similaritiesi

Belongs to the invertebrate defensin family. Type 2 subfamily.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR001542 Defensin_invertebrate/fungal
IPR036574 Scorpion_toxin-like_sf
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51378 INVERT_DEFENSINS, 1 hit

Sequencei

Sequence statusi: Complete.

P84156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
DKLIGSCVWG AVNYTSNCNA ECKRRGYKGG HCGSFANVNC WCET
Length:44
Mass (Da):4,803
Last modified:September 13, 2004 - v1
Checksum:i367DC7B793DCFCD5
GO

Mass spectrometryi

Molecular mass is 4803.4 Da from positions 1 - 44. Determined by MALDI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OZZNMR-A1-44[»]
1P00NMR-A1-44[»]
1P0ANMR-A1-44[»]
ProteinModelPortaliP84156
SMRiP84156
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP84156

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR001542 Defensin_invertebrate/fungal
IPR036574 Scorpion_toxin-like_sf
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51378 INVERT_DEFENSINS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEFN_ARCDE
AccessioniPrimary (citable) accession number: P84156
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2004
Last modified: October 25, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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