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Protein

Brevinin-1BYc

Gene
N/A
Organism
Rana boylii (Foothill yellow-legged frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antibacterial activity against Gram-positive bacterium S.aureus. Weak antifungal activity against C.albicans.1 Publication

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Antibiotic, Antimicrobial, Fungicide
Biological processCytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Brevinin-1BYc
OrganismiRana boylii (Foothill yellow-legged frog)
Taxonomic identifieri160499 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaRana

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000435341 – 24Brevinin-1BYcAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 241 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.1 Publication

Family and domain databases

InterProiView protein in InterPro
IPR012520 Antimicrobial_frog_1
PfamiView protein in Pfam
PF08018 Antimicrobial_1, 1 hit

Sequencei

Sequence statusi: Complete.

P84113-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
FLPILASLAA TLGPKLLCLI TKKC
Length:24
Mass (Da):2,528
Last modified:August 16, 2004 - v1
Checksum:i4CC2E08E069C9EFA
GO

Mass spectrometryi

Molecular mass is 2524.5 Da from positions 1 - 24. Determined by MALDI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012520 Antimicrobial_frog_1
PfamiView protein in Pfam
PF08018 Antimicrobial_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBR1YC_RANBO
AccessioniPrimary (citable) accession number: P84113
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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