SRSF3

Functionⁱ

Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific (PubMed:17036044).5 Publications

GO - Molecular functionⁱ

phospholipase binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 26876937
sequence-specific mRNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to leukemia inhibitory factor Source: Ensembl
mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: Reactome
mRNA splicing, via spliceosome Source: Reactome
regulation of mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 26876937
RNA export from nucleus Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing
SIGNORⁱ	P84103

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/arginine-rich splicing factor 3 Alternative name(s): Pre-mRNA-splicing factor SRP20 Splicing factor, arginine/serine-rich 3
Gene namesⁱ	Name:SRSF3 Synonyms:SFRS3, SRP20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112081.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10785 SRSF3
MIMⁱ	603364 gene
neXtProtⁱ	NX_P84103

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	86	R → E: Abolishes interaction with NXF1. 1 Publication	1
Mutagenesisⁱ	88	R → E: Abolishes interaction with NXF1. 1 Publication	1
Mutagenesisⁱ	90	R → E: Abolishes interaction with NXF1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6428
Open Targets More...OpenTargetsⁱ	ENSG00000112081
PharmGKBⁱ	PA35701

Polymorphism and mutation databases

BioMutaⁱ	SRSF3
DMDMⁱ	51338672

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081923	1 – 164	Serine/arginine-rich splicing factor 3Add BLAST		164

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	23	N6-acetyllysineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P84103
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P84103
PaxDbⁱ	P84103
PeptideAtlas More...PeptideAtlasⁱ	P84103
PRIDEⁱ	P84103
ProteomicsDBⁱ	57753
TopDownProteomicsⁱ	P84103-1 [P84103-1]

PTM databases

iPTMnetⁱ	P84103
PhosphoSitePlusⁱ	P84103
SwissPalmⁱ	P84103

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000112081
CleanExⁱ	HS_SFRS3
ExpressionAtlasⁱ	P84103 baseline and differential
Genevisibleⁱ	P84103 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB012986 HPA056981

HPAⁱ

CAB012986
HPA056981

Interactionⁱ

Subunit structureⁱ

Interacts with CPSF6 (PubMed:15169763). Interacts with RBMY1A1 (PubMed:15595951). Interacts with SREK1/SFRS12 (PubMed:10757789). Interacts with NXF1 (PubMed:12667464, PubMed:17036044). Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:26876937, PubMed:28984244).7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NXF1	Q9UBU9	4	EBI-372557,EBI-398874
PCBP2	Q15366	3	EBI-372557,EBI-945799
PCDHB14	Q9Y5E9	4	EBI-372557,EBI-10329013
RNPS1	Q15287	4	EBI-372557,EBI-395959
Srek1	Q9JKL7	3	EBI-372557,EBI-6452221	From Rattus norvegicus.

Show more details

GO - Molecular functionⁱ

phospholipase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112326, 135 interactors
CORUMⁱ	P84103
Database of interacting proteins More...DIPⁱ	DIP-32961N
IntActⁱ	P84103, 61 interactors
Molecular INTeraction database More...MINTⁱ	P84103
STRINGⁱ	9606.ENSP00000362820

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	3 – 6	Combined sources	4
Beta strandⁱ	11 – 16	Combined sources	6
Turnⁱ	18 – 20	Combined sources	3
Helixⁱ	24 – 33	Combined sources	10
Beta strandⁱ	36 – 41	Combined sources	6
Beta strandⁱ	43 – 45	Combined sources	3
Beta strandⁱ	47 – 55	Combined sources	9
Helixⁱ	56 – 66	Combined sources	11
Beta strandⁱ	67 – 69	Combined sources	3
Beta strandⁱ	71 – 74	Combined sources	4
Beta strandⁱ	77 – 80	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2I2Y	NMR	-	A	1-86	[»]
	2I38	NMR	-	A	1-86	[»]
ProteinModelPortalⁱ	P84103
SMRⁱ	P84103
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P84103

EvolutionaryTraceⁱ

P84103

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	10 – 83	RRMPROSITE-ProRule annotationAdd BLAST	74
Repeatⁱ	119 – 133	B-1Add BLAST	15
Repeatⁱ	149 – 164	B-2Add BLAST	16

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 90	Sufficient for interaction with NXF1Add BLAST		90
Regionⁱ	119 – 164	2 X approximate repeats, basicAdd BLAST		46

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	86 – 164	Arg/Ser-rich (RS domain)Add BLAST		79

Sequence similaritiesⁱ

Belongs to the splicing factor SR family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0107 Eukaryota ENOG4111N8Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144115
HOGENOMⁱ	HOG000208722
HOVERGENⁱ	HBG107480
InParanoidⁱ	P84103
KEGG Orthology (KO) More...KOⁱ	K12892
OMAⁱ	HSVWIAR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G17YQ
PhylomeDBⁱ	P84103
TreeFamⁱ	TF351858

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P84103-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHRDSCPLDC KVYVGNLGNN GNKTELERAF GYYGPLRSVW VARNPPGFAF 
        60         70         80         90        100
VEFEDPRDAA DAVRELDGRT LCGCRVRVEL SNGEKRSRNR GPPPSWGRRP 
       110        120        130        140        150
RDDYRRRSPP PRRRSPRRRS FSRSRSRSLS RDRRRERSLS RERNHKPSRS 
       160 
FSRSRSRSRS NERK

Length:164

Mass (Da):19,330

Last modified:August 16, 2004 - v1

Checksum:ⁱ02F0A5EE33FF28A0

GO

Isoform 2 (identifier: P84103-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
115-164: SPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK → VTIMSLLTTL

« Hide

        10         20         30         40         50
MHRDSCPLDC KVYVGNLGNN GNKTELERAF GYYGPLRSVW VARNPPGFAF 
        60         70         80         90        100
VEFEDPRDAA DAVRELDGRT LCGCRVRVEL SNGEKRSRNR GPPPSWGRRP 
       110        120 
RDDYRRRSPP PRRRVTIMSL LTTL

Note: No experimental confirmation available.

Show »

Length:124

Mass (Da):14,203

Checksum:ⁱ78979851C38232C1

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056243	115 – 164	SPRRR…SNERK → VTIMSLLTTL in isoform 2. 1 PublicationAdd BLAST		50

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10838 mRNA Translation: AAA36648.1 AF107405 mRNA Translation: AAD44523.1 AK304097 mRNA Translation: BAG65003.1 BT007017 mRNA Translation: AAP35663.1 Z85986 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03898.1 BC000914 mRNA Translation: AAH00914.1 BC069018 mRNA Translation: AAH69018.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4823.1 [P84103-1]
PIRⁱ	I54089
NCBI Reference Sequences More...RefSeqⁱ	NP_003008.1, NM_003017.4 [P84103-1]
UniGeneⁱ	Hs.405144

Genome annotation databases

Ensemblⁱ	ENST00000373715; ENSP00000362820; ENSG00000112081 [P84103-1] ENST00000477442; ENSP00000436036; ENSG00000112081 [P84103-2] ENST00000620941; ENSP00000482833; ENSG00000112081 [P84103-1]
GeneIDⁱ	6428
KEGGⁱ	hsa:6428
UCSC genome browser More...UCSCⁱ	uc003omj.4 human [P84103-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P84103	Serine/arginine-rich splicing factor 3		BOVIN		164
Serine/arginine-rich splicing factor 3		MOUSE		164
Splicing factor arginine/serine-rich 3		HUMAN		164
Serine/arginine-rich splicing factor		Daphnia magna		164
Serine and arginine rich splicing factor 3		CALJA		164
+76
P84103-2	MCG21131, isoform CRA_a		MOUSE		124
SRSF3 isoform 5		PANTR		124
SRSF3 isoform 5		PONAB		124
Serine and arginine rich splicing factor 3		PROCO		124
Serine and arginine rich splicing factor 3		SAIBB		124
+21

Protein	Similar proteins		Species	Score	Length
P84103	Serine/arginine-rich splicing factor 3		BOVIN		164
Serine/arginine-rich splicing factor 3		MOUSE		164
Splicing factor arginine/serine-rich 3		HUMAN		164
Serine/arginine-rich splicing factor		Daphnia magna		164
Serine and arginine rich splicing factor 3		CALJA		164
+92
P84103-2	Uncharacterized protein		GASAC		147
Uncharacterized protein		AOTNA		152
Splicing factor, arginine/serine-rich 3		CRIGR		161
Splicing factor, arginine/serine-rich 3 (Fragment)		ANAPL		119
Uncharacterized protein		FELCA		142
+43

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10838 mRNA Translation: AAA36648.1 AF107405 mRNA Translation: AAD44523.1 AK304097 mRNA Translation: BAG65003.1 BT007017 mRNA Translation: AAP35663.1 Z85986 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03898.1 BC000914 mRNA Translation: AAH00914.1 BC069018 mRNA Translation: AAH69018.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4823.1 [P84103-1]
PIRⁱ	I54089
NCBI Reference Sequences More...RefSeqⁱ	NP_003008.1, NM_003017.4 [P84103-1]
UniGeneⁱ	Hs.405144

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2I2Y	NMR	-	A	1-86	[»]
	2I38	NMR	-	A	1-86	[»]
ProteinModelPortalⁱ	P84103
SMRⁱ	P84103
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112326, 135 interactors
CORUMⁱ	P84103
Database of interacting proteins More...DIPⁱ	DIP-32961N
IntActⁱ	P84103, 61 interactors
Molecular INTeraction database More...MINTⁱ	P84103
STRINGⁱ	9606.ENSP00000362820

PTM databases

iPTMnetⁱ	P84103
PhosphoSitePlusⁱ	P84103
SwissPalmⁱ	P84103

Polymorphism and mutation databases

BioMutaⁱ	SRSF3
DMDMⁱ	51338672

Proteomic databases

EPDⁱ	P84103
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P84103
PaxDbⁱ	P84103
PeptideAtlas More...PeptideAtlasⁱ	P84103
PRIDEⁱ	P84103
ProteomicsDBⁱ	57753
TopDownProteomicsⁱ	P84103-1 [P84103-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6428
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373715; ENSP00000362820; ENSG00000112081 [P84103-1] ENST00000477442; ENSP00000436036; ENSG00000112081 [P84103-2] ENST00000620941; ENSP00000482833; ENSG00000112081 [P84103-1]
GeneIDⁱ	6428
KEGGⁱ	hsa:6428
UCSC genome browser More...UCSCⁱ	uc003omj.4 human [P84103-1]

Organism-specific databases

CTDⁱ	6428
DisGeNET More...DisGeNETⁱ	6428
EuPathDBⁱ	HostDB:ENSG00000112081.16
GeneCardsⁱ	SRSF3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10785 SRSF3
Human Protein Atlas More...HPAⁱ	CAB012986 HPA056981
MIMⁱ	603364 gene
neXtProtⁱ	NX_P84103
Open Targets More...OpenTargetsⁱ	ENSG00000112081
PharmGKBⁱ	PA35701
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0107 Eukaryota ENOG4111N8Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144115
HOGENOMⁱ	HOG000208722
HOVERGENⁱ	HBG107480
InParanoidⁱ	P84103
KEGG Orthology (KO) More...KOⁱ	K12892
OMAⁱ	HSVWIAR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G17YQ
PhylomeDBⁱ	P84103
TreeFamⁱ	TF351858

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing
SIGNORⁱ	P84103

Miscellaneous databases

ChiTaRSⁱ	SRSF3 human
EvolutionaryTraceⁱ	P84103
GeneWikiⁱ	SFRS3
GenomeRNAiⁱ	6428
Protein Ontology More...PROⁱ	PR:P84103
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112081
CleanExⁱ	HS_SFRS3
ExpressionAtlasⁱ	P84103 baseline and differential
Genevisibleⁱ	P84103 HS

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRSF3_HUMAN
Accessionⁱ	P84103Primary (citable) accession number: P84103 Secondary accession number(s): B4E241 , O08831, P23152, Q5R3K0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	August 16, 2004
	Last modified:	June 20, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P84103 (SRSF3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Serine/arginine-rich splicing factor 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ