UniProtKB - P84103 (SRSF3_HUMAN)
Serine/arginine-rich splicing factor 3
SRSF3
Functioni
GO - Molecular functioni
- phospholipase binding Source: Ensembl
- RNA binding Source: UniProtKB
- sequence-specific mRNA binding Source: Ensembl
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
- mRNA 3'-end processing Source: Reactome
- mRNA cis splicing, via spliceosome Source: GO_Central
- mRNA export from nucleus Source: UniProtKB
- mRNA splicing, via spliceosome Source: Reactome
- regulation of alternative mRNA splicing, via spliceosome Source: GO_Central
- regulation of mRNA splicing, via spliceosome Source: UniProtKB
- RNA export from nucleus Source: Reactome
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing, mRNA transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P84103 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
SIGNORi | P84103 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/arginine-rich splicing factor 3Alternative name(s): Pre-mRNA-splicing factor SRP20 Splicing factor, arginine/serine-rich 3 |
Gene namesi | Name:SRSF3 Synonyms:SFRS3, SRP20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112081.16 |
HGNCi | HGNC:10785, SRSF3 |
MIMi | 603364, gene |
neXtProti | NX_P84103 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- Nucleus speckle 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Recruited to nuclear speckles following interaction with YTHDC1.1 Publication
Nucleus
- nuclear speck Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 86 | R → E: Abolishes interaction with NXF1. 1 Publication | 1 | |
Mutagenesisi | 88 | R → E: Abolishes interaction with NXF1. 1 Publication | 1 | |
Mutagenesisi | 90 | R → E: Abolishes interaction with NXF1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6428 |
OpenTargetsi | ENSG00000112081 |
PharmGKBi | PA35701 |
Miscellaneous databases
Pharosi | P84103, Tbio |
Polymorphism and mutation databases
BioMutai | SRSF3 |
DMDMi | 51338672 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081923 | 1 – 164 | Serine/arginine-rich splicing factor 3Add BLAST | 164 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 5 | PhosphoserineCombined sources | 1 | |
Modified residuei | 23 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P84103 |
jPOSTi | P84103 |
MassIVEi | P84103 |
MaxQBi | P84103 |
PaxDbi | P84103 |
PeptideAtlasi | P84103 |
PRIDEi | P84103 |
ProteomicsDBi | 57753 [P84103-1] 5800 |
TopDownProteomicsi | P84103-1 [P84103-1] |
PTM databases
iPTMneti | P84103 |
PhosphoSitePlusi | P84103 |
SwissPalmi | P84103 |
Expressioni
Gene expression databases
Bgeei | ENSG00000112081, Expressed in testis and 250 other tissues |
ExpressionAtlasi | P84103, baseline and differential |
Genevisiblei | P84103, HS |
Organism-specific databases
HPAi | ENSG00000112081, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CPSF6 (PubMed:15169763).
Interacts with RBMY1A1 (PubMed:15595951).
Interacts with SREK1/SFRS12 (PubMed:10757789).
Interacts with NXF1 (PubMed:12667464, PubMed:17036044).
Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:26876937, PubMed:28984244).
7 PublicationsBinary interactionsi
Hide detailsP84103
GO - Molecular functioni
- phospholipase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112326, 202 interactors |
CORUMi | P84103 |
DIPi | DIP-32961N |
IntActi | P84103, 79 interactors |
MINTi | P84103 |
STRINGi | 9606.ENSP00000362820 |
Miscellaneous databases
RNActi | P84103, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P84103 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P84103 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 83 | RRMPROSITE-ProRule annotationAdd BLAST | 74 | |
Repeati | 119 – 133 | B-1Add BLAST | 15 | |
Repeati | 149 – 164 | B-2Add BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 90 | Sufficient for interaction with NXF1Add BLAST | 90 | |
Regioni | 119 – 164 | 2 X approximate repeats, basicAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 86 – 164 | Arg/Ser-rich (RS domain)Add BLAST | 79 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0107, Eukaryota |
GeneTreei | ENSGT00910000144115 |
HOGENOMi | CLU_012062_20_2_1 |
InParanoidi | P84103 |
OMAi | MDDQEGR |
PhylomeDBi | P84103 |
TreeFami | TF351858 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
IDEALi | IID00204 |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHRDSCPLDC KVYVGNLGNN GNKTELERAF GYYGPLRSVW VARNPPGFAF
60 70 80 90 100
VEFEDPRDAA DAVRELDGRT LCGCRVRVEL SNGEKRSRNR GPPPSWGRRP
110 120 130 140 150
RDDYRRRSPP PRRRSPRRRS FSRSRSRSLS RDRRRERSLS RERNHKPSRS
160
FSRSRSRSRS NERK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X2D0 | A0A087X2D0_HUMAN | Serine/arginine-rich-splicing facto... | SRSF3 | 95 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056243 | 115 – 164 | SPRRR…SNERK → VTIMSLLTTL in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10838 mRNA Translation: AAA36648.1 AF107405 mRNA Translation: AAD44523.1 AK304097 mRNA Translation: BAG65003.1 BT007017 mRNA Translation: AAP35663.1 Z85986 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03898.1 BC000914 mRNA Translation: AAH00914.1 BC069018 mRNA Translation: AAH69018.1 |
CCDSi | CCDS4823.1 [P84103-1] |
PIRi | I54089 |
RefSeqi | NP_003008.1, NM_003017.4 [P84103-1] |
Genome annotation databases
Ensembli | ENST00000373715; ENSP00000362820; ENSG00000112081 [P84103-1] ENST00000477442; ENSP00000436036; ENSG00000112081 [P84103-2] ENST00000620941; ENSP00000482833; ENSG00000112081 [P84103-1] |
GeneIDi | 6428 |
KEGGi | hsa:6428 |
UCSCi | uc003omj.4, human [P84103-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10838 mRNA Translation: AAA36648.1 AF107405 mRNA Translation: AAD44523.1 AK304097 mRNA Translation: BAG65003.1 BT007017 mRNA Translation: AAP35663.1 Z85986 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03898.1 BC000914 mRNA Translation: AAH00914.1 BC069018 mRNA Translation: AAH69018.1 |
CCDSi | CCDS4823.1 [P84103-1] |
PIRi | I54089 |
RefSeqi | NP_003008.1, NM_003017.4 [P84103-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2I2Y | NMR | - | A | 1-86 | [»] | |
2I38 | NMR | - | A | 1-86 | [»] | |
SMRi | P84103 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112326, 202 interactors |
CORUMi | P84103 |
DIPi | DIP-32961N |
IntActi | P84103, 79 interactors |
MINTi | P84103 |
STRINGi | 9606.ENSP00000362820 |
PTM databases
iPTMneti | P84103 |
PhosphoSitePlusi | P84103 |
SwissPalmi | P84103 |
Polymorphism and mutation databases
BioMutai | SRSF3 |
DMDMi | 51338672 |
Proteomic databases
EPDi | P84103 |
jPOSTi | P84103 |
MassIVEi | P84103 |
MaxQBi | P84103 |
PaxDbi | P84103 |
PeptideAtlasi | P84103 |
PRIDEi | P84103 |
ProteomicsDBi | 57753 [P84103-1] 5800 |
TopDownProteomicsi | P84103-1 [P84103-1] |
Protocols and materials databases
Antibodypediai | 29693, 272 antibodies |
DNASUi | 6428 |
Genome annotation databases
Ensembli | ENST00000373715; ENSP00000362820; ENSG00000112081 [P84103-1] ENST00000477442; ENSP00000436036; ENSG00000112081 [P84103-2] ENST00000620941; ENSP00000482833; ENSG00000112081 [P84103-1] |
GeneIDi | 6428 |
KEGGi | hsa:6428 |
UCSCi | uc003omj.4, human [P84103-1] |
Organism-specific databases
CTDi | 6428 |
DisGeNETi | 6428 |
EuPathDBi | HostDB:ENSG00000112081.16 |
GeneCardsi | SRSF3 |
HGNCi | HGNC:10785, SRSF3 |
HPAi | ENSG00000112081, Low tissue specificity |
MIMi | 603364, gene |
neXtProti | NX_P84103 |
OpenTargetsi | ENSG00000112081 |
PharmGKBi | PA35701 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0107, Eukaryota |
GeneTreei | ENSGT00910000144115 |
HOGENOMi | CLU_012062_20_2_1 |
InParanoidi | P84103 |
OMAi | MDDQEGR |
PhylomeDBi | P84103 |
TreeFami | TF351858 |
Enzyme and pathway databases
PathwayCommonsi | P84103 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
SIGNORi | P84103 |
Miscellaneous databases
BioGRID-ORCSi | 6428, 769 hits in 850 CRISPR screens |
ChiTaRSi | SRSF3, human |
EvolutionaryTracei | P84103 |
GeneWikii | SFRS3 |
GenomeRNAii | 6428 |
Pharosi | P84103, Tbio |
PROi | PR:P84103 |
RNActi | P84103, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112081, Expressed in testis and 250 other tissues |
ExpressionAtlasi | P84103, baseline and differential |
Genevisiblei | P84103, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
IDEALi | IID00204 |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRSF3_HUMAN | |
Accessioni | P84103Primary (citable) accession number: P84103 Secondary accession number(s): B4E241 Q5R3K0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families