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Protein

60S ribosomal protein L19

Gene

RPL19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 5.8S rRNA binding Source: Ensembl
  • large ribosomal subunit rRNA binding Source: Ensembl
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L19
Alternative name(s):
Large ribosomal subunit protein eL191 Publication
Gene namesi
Name:RPL19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108298.9
HGNCiHGNC:10312 RPL19
MIMi180466 gene
neXtProtiNX_P84098

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6143
OpenTargetsiENSG00000108298
PharmGKBiPA34681

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

Polymorphism and mutation databases

BioMutaiRPL19
DMDMi51338661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001311691 – 19660S ribosomal protein L19Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5CitrullineBy similarity1
Modified residuei13PhosphoserineCombined sources1
Modified residuei16CitrullineBy similarity1
Modified residuei38CitrullineBy similarity1
Modified residuei164PhosphoserineCombined sources1
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei187PhosphothreonineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP84098
MaxQBiP84098
PaxDbiP84098
PeptideAtlasiP84098
PRIDEiP84098
ProteomicsDBi57751
TopDownProteomicsiP84098

PTM databases

iPTMnetiP84098
PhosphoSitePlusiP84098
SwissPalmiP84098

Expressioni

Gene expression databases

BgeeiENSG00000108298
CleanExiHS_RPL19
ExpressionAtlasiP84098 baseline and differential
GenevisibleiP84098 HS

Organism-specific databases

HPAiHPA043014
HPA051987

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-916524,EBI-710997

Protein-protein interaction databases

BioGridi112063, 161 interactors
CORUMiP84098
IntActiP84098, 27 interactors
MINTiP84098
STRINGi9606.ENSP00000225430

Structurei

3D structure databases

ProteinModelPortaliP84098
SMRiP84098
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1696 Eukaryota
COG2147 LUCA
GeneTreeiENSGT00390000012628
HOGENOMiHOG000231277
HOVERGENiHBG056059
InParanoidiP84098
KOiK02885
OMAiNRVWIDP
OrthoDBiEOG091G0MKY
PhylomeDBiP84098
TreeFamiTF313598

Family and domain databases

CDDicd01417 Ribosomal_L19e_E, 1 hit
Gene3Di1.10.1650.10, 1 hit
HAMAPiMF_01475 Ribosomal_L19e, 1 hit
InterProiView protein in InterPro
IPR035970 60S_ribosomal_L19/L19e_sf
IPR000196 Ribosomal_L19/L19e
IPR023638 Ribosomal_L19/L19e_CS
IPR015972 Ribosomal_L19/L19e_dom1
IPR033935 Ribosomal_L19_euka
PfamiView protein in Pfam
PF01280 Ribosomal_L19e, 1 hit
SMARTiView protein in SMART
SM01416 Ribosomal_L19e, 1 hit
SUPFAMiSSF48140 SSF48140, 1 hit
PROSITEiView protein in PROSITE
PS00526 RIBOSOMAL_L19E, 1 hit

Sequencei

Sequence statusi: Complete.

P84098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI
60 70 80 90 100
IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR
110 120 130 140 150
ILRRLLRRYR ESKKIDRHMY HSLYLKVKGN VFKNKRILME HIHKLKADKA
160 170 180 190
RKKLLADQAE ARRSKTKEAR KRREERLQAK KEEIIKTLSK EEETKK
Length:196
Mass (Da):23,466
Last modified:August 16, 2004 - v1
Checksum:i4AF506393E526216
GO

Sequence cautioni

The sequence CAD97677 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63527 mRNA Translation: CAA45090.1
S56985 mRNA Translation: AAB25672.1
AK311858 mRNA Translation: BAG34799.1
BX537435 mRNA Translation: CAD97677.1 Different initiation.
BC000530 mRNA Translation: AAH00530.1
BC013016 mRNA Translation: AAH13016.1
BC062709 mRNA Translation: AAH62709.1
BC066315 mRNA Translation: AAH66315.1
BC095445 mRNA Translation: AAH95445.1
CCDSiCCDS42312.1
PIRiA48992
RefSeqiNP_000972.1, NM_000981.3
UniGeneiHs.381061
Hs.655411

Genome annotation databases

EnsembliENST00000225430; ENSP00000225430; ENSG00000108298
GeneIDi6143
KEGGihsa:6143
UCSCiuc002hrq.1 human

Similar proteinsi

Entry informationi

Entry nameiRL19_HUMAN
AccessioniPrimary (citable) accession number: P84098
Secondary accession number(s): B2R4K2
, P14118, P22908, Q502Y6, Q7Z6E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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