UniProtKB - P84096 (RHOG_MOUSE)
Protein
Rho-related GTP-binding protein RhoG
Gene
Rhog
Organism
Mus musculus (Mouse)
Status
Functioni
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 17 | GTPBy similarity | 8 | |
Nucleotide bindingi | 57 – 61 | GTPBy similarity | 5 | |
Nucleotide bindingi | 115 – 118 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: MGI
- GTP binding Source: GO_Central
- protein kinase binding Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: MGI
- actin filament organization Source: GO_Central
- activation of GTPase activity Source: UniProtKB
- cell chemotaxis Source: UniProtKB
- cell projection assembly Source: GO_Central
- cortical cytoskeleton organization Source: GO_Central
- engulfment of apoptotic cell Source: GO_Central
- establishment or maintenance of cell polarity Source: GO_Central
- motor neuron axon guidance Source: GO_Central
- positive regulation of protein localization to plasma membrane Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: MGI
- Rac protein signal transduction Source: MGI
- regulation of actin cytoskeleton organization Source: GO_Central
- regulation of cell shape Source: GO_Central
- regulation of neutrophil migration Source: GO_Central
- regulation of ruffle assembly Source: MGI
- Rho protein signal transduction Source: MGI
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-114604, GPVI-mediated activation cascade R-MMU-1257604, PIP3 activates AKT signaling R-MMU-194840, Rho GTPase cycle R-MMU-5625970, RHO GTPases activate KTN1 R-MMU-6798695, Neutrophil degranulation R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Rho-related GTP-binding protein RhoGAlternative name(s): Sid 10750 |
Gene namesi | Name:Rhog Synonyms:Arhg, Sid10750 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1928370, Rhog |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Cytoskeleton
- cytoskeleton Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell cortex Source: GO_Central
- cell projection Source: GO_Central
- cytoplasm Source: GO_Central
- cytoplasmic vesicle Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
- vesicle Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000042030 | 1 – 188 | Rho-related GTP-binding protein RhoGAdd BLAST | 188 | |
PropeptideiPRO_0000042031 | 189 – 191 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 138 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 180 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 188 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 188 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, Phosphoprotein, PrenylationProteomic databases
EPDi | P84096 |
jPOSTi | P84096 |
PaxDbi | P84096 |
PeptideAtlasi | P84096 |
PRIDEi | P84096 |
PTM databases
iPTMneti | P84096 |
PhosphoSitePlusi | P84096 |
SwissPalmi | P84096 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000073982, Expressed in granulocyte and 279 other tissues |
Genevisiblei | P84096, MM |
Interactioni
Subunit structurei
Interacts with ARHGEF26.
Interacts with ARHGEF16 (By similarity).
By similarityGO - Molecular functioni
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 207846, 4 interactors |
CORUMi | P84096 |
IntActi | P84096, 2 interactors |
MINTi | P84096 |
STRINGi | 10090.ENSMUSP00000095832 |
Miscellaneous databases
RNActi | P84096, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 32 – 40 | Effector regionSequence analysis | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
GeneTreei | ENSGT00940000155158 |
HOGENOMi | CLU_041217_21_3_1 |
InParanoidi | P84096 |
OMAi | HCPDAPV |
OrthoDBi | 1091615at2759 |
PhylomeDBi | P84096 |
TreeFami | TF101109 |
Family and domain databases
CDDi | cd01875, RhoG, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR042734, RhoG IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P84096-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT
60 70 80 90 100
VNLNLWDTAG QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE
110 120 130 140 150
VCHHCPDVPI LLVGTKKDLR AQPDTLRRLK EQGQAPITPQ QGQALAKQIH
160 170 180 190
AVRYLECSAL QQDGVKEVFA EAVRAVLNPT PIKRGRSCIL L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GSL4 | A0A1B0GSL4_MOUSE | Rho-related GTP-binding protein Rho... | Rhog | 83 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB025943 mRNA Translation: BAA84696.1 BC059775 mRNA Translation: AAH59775.1 |
CCDSi | CCDS21529.1 |
RefSeqi | NP_062512.1, NM_019566.3 |
Genome annotation databases
Ensembli | ENSMUST00000098230; ENSMUSP00000095832; ENSMUSG00000073982 ENSMUST00000106923; ENSMUSP00000102536; ENSMUSG00000073982 |
GeneIDi | 56212 |
KEGGi | mmu:56212 |
UCSCi | uc009irk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB025943 mRNA Translation: BAA84696.1 BC059775 mRNA Translation: AAH59775.1 |
CCDSi | CCDS21529.1 |
RefSeqi | NP_062512.1, NM_019566.3 |
3D structure databases
SMRi | P84096 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207846, 4 interactors |
CORUMi | P84096 |
IntActi | P84096, 2 interactors |
MINTi | P84096 |
STRINGi | 10090.ENSMUSP00000095832 |
PTM databases
iPTMneti | P84096 |
PhosphoSitePlusi | P84096 |
SwissPalmi | P84096 |
Proteomic databases
EPDi | P84096 |
jPOSTi | P84096 |
PaxDbi | P84096 |
PeptideAtlasi | P84096 |
PRIDEi | P84096 |
Protocols and materials databases
Antibodypediai | 23440, 190 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000098230; ENSMUSP00000095832; ENSMUSG00000073982 ENSMUST00000106923; ENSMUSP00000102536; ENSMUSG00000073982 |
GeneIDi | 56212 |
KEGGi | mmu:56212 |
UCSCi | uc009irk.1, mouse |
Organism-specific databases
CTDi | 391 |
MGIi | MGI:1928370, Rhog |
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
GeneTreei | ENSGT00940000155158 |
HOGENOMi | CLU_041217_21_3_1 |
InParanoidi | P84096 |
OMAi | HCPDAPV |
OrthoDBi | 1091615at2759 |
PhylomeDBi | P84096 |
TreeFami | TF101109 |
Enzyme and pathway databases
Reactomei | R-MMU-114604, GPVI-mediated activation cascade R-MMU-1257604, PIP3 activates AKT signaling R-MMU-194840, Rho GTPase cycle R-MMU-5625970, RHO GTPases activate KTN1 R-MMU-6798695, Neutrophil degranulation R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Miscellaneous databases
BioGRID-ORCSi | 56212, 2 hits in 17 CRISPR screens |
PROi | PR:P84096 |
RNActi | P84096, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000073982, Expressed in granulocyte and 279 other tissues |
Genevisiblei | P84096, MM |
Family and domain databases
CDDi | cd01875, RhoG, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR042734, RhoG IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHOG_MOUSE | |
Accessioni | P84096Primary (citable) accession number: P84096 Secondary accession number(s): P35238, Q8NI04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families