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Protein

Rho-related GTP-binding protein RhoG

Gene

RHOG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • activation of GTPase activity Source: UniProtKB
  • cell chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: Reactome
  • neutrophil degranulation Source: Reactome
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: MGI
  • Rac protein signal transduction Source: MGI
  • regulation of ruffle assembly Source: Ensembl
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • Rho protein signal transduction Source: MGI

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoG
Gene namesi
Name:RHOG
Synonyms:ARHG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177105.9
HGNCiHGNC:672 RHOG
MIMi179505 gene
neXtProtiNX_P84095

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi391
OpenTargetsiENSG00000177105
PharmGKBiPA24955

Polymorphism and mutation databases

BioMutaiRHOG
DMDMi51338611

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000420281 – 188Rho-related GTP-binding protein RhoGAdd BLAST188
PropeptideiPRO_0000042029189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39ADP-ribosylasparagine; by botulinum toxinBy similarity1
Modified residuei138PhosphothreonineCombined sources1
Modified residuei180PhosphothreonineCombined sources1
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP84095
PaxDbiP84095
PeptideAtlasiP84095
PRIDEiP84095
ProteomicsDBi57750

PTM databases

iPTMnetiP84095
PhosphoSitePlusiP84095
SwissPalmiP84095

Expressioni

Gene expression databases

BgeeiENSG00000177105
CleanExiHS_RHOG
ExpressionAtlasiP84095 baseline and differential
GenevisibleiP84095 HS

Organism-specific databases

HPAiHPA039871

Interactioni

Subunit structurei

Interacts with ARHGEF26. Interacts with ARHGEF16.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ELMO1Q925563EBI-446579,EBI-346417

Protein-protein interaction databases

BioGridi106884, 17 interactors
IntActiP84095, 7 interactors
STRINGi9606.ENSP00000339467

Structurei

3D structure databases

ProteinModelPortaliP84095
SMRiP84095
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP84095
KOiK07863
OMAiHCPDAPV
OrthoDBiEOG091G0KCM
PhylomeDBiP84095
TreeFamiTF101109

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT
60 70 80 90 100
VNLNLWDTAG QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE
110 120 130 140 150
VCHHCPDVPI LLVGTKKDLR AQPDTLRRLK EQGQAPITPQ QGQALAKQIH
160 170 180 190
AVRYLECSAL QQDGVKEVFA EAVRAVLNPT PIKRGRSCIL L
Length:191
Mass (Da):21,309
Last modified:August 16, 2004 - v1
Checksum:i0C4FE9C54140F499
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133G → S in CAA43784 (PubMed:1620121).Curated1
Sequence conflicti169F → L in AAM21121 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11317 mRNA Translation: AAA60268.1
X61587 mRNA Translation: CAA43784.1
AF498974 mRNA Translation: AAM21121.1
AY563952 mRNA Translation: AAS75333.1
CCDSiCCDS7748.1
PIRiS25722 TVHURG
RefSeqiNP_001656.2, NM_001665.3
XP_005252973.1, XM_005252916.2
XP_016873208.1, XM_017017719.1
UniGeneiHs.501728

Genome annotation databases

EnsembliENST00000351018; ENSP00000339467; ENSG00000177105
ENST00000396978; ENSP00000380175; ENSG00000177105
ENST00000396979; ENSP00000380176; ENSG00000177105
ENST00000533217; ENSP00000436932; ENSG00000177105
GeneIDi391
KEGGihsa:391

Similar proteinsi

Entry informationi

Entry nameiRHOG_HUMAN
AccessioniPrimary (citable) accession number: P84095
Secondary accession number(s): P35238, Q8NI04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 18, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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