UniProtKB - P84090 (ERH_HUMAN)
Protein
Enhancer of rudimentary homolog
Gene
ERH
Organism
Homo sapiens (Human)
Status
Functioni
May have a role in the cell cycle.
GO - Molecular functioni
- methyl-CpG binding Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- nucleobase-containing compound metabolic process Source: ProtInc
- pyrimidine nucleoside metabolic process Source: ProtInc
Keywordsi
Biological process | Cell cycle |
Enzyme and pathway databases
PathwayCommonsi | P84090 |
Names & Taxonomyi
Protein namesi | Recommended name: Enhancer of rudimentary homolog |
Gene namesi | Name:ERH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3447, ERH |
MIMi | 601191, gene |
neXtProti | NX_P84090 |
VEuPathDBi | HostDB:ENSG00000100632.10 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Other locations
- methylosome Source: UniProtKB
- midbody Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2079 |
OpenTargetsi | ENSG00000100632 |
PharmGKBi | PA27859 |
Miscellaneous databases
Pharosi | P84090, Tbio |
Genetic variation databases
BioMutai | ERH |
DMDMi | 51317296 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000219351 | 2 – 104 | Enhancer of rudimentary homologAdd BLAST | 103 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 11 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P84090 |
jPOSTi | P84090 |
MassIVEi | P84090 |
MaxQBi | P84090 |
PaxDbi | P84090 |
PeptideAtlasi | P84090 |
PRIDEi | P84090 |
ProteomicsDBi | 57749 |
TopDownProteomicsi | P84090 |
PTM databases
iPTMneti | P84090 |
PhosphoSitePlusi | P84090 |
SwissPalmi | P84090 |
Expressioni
Tissue specificityi
Expressed in all tissues examined.1 Publication
Gene expression databases
Bgeei | ENSG00000100632, Expressed in pituitary gland and 251 other tissues |
ExpressionAtlasi | P84090, baseline and differential |
Genevisiblei | P84090, HS |
Organism-specific databases
HPAi | ENSG00000100632, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP84090
Protein-protein interaction databases
BioGRIDi | 108390, 143 interactors |
CORUMi | P84090 |
DIPi | DIP-42473N |
IntActi | P84090, 64 interactors |
MINTi | P84090 |
STRINGi | 9606.ENSP00000451080 |
Miscellaneous databases
RNActi | P84090, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P84090 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P84090 |
Family & Domainsi
Sequence similaritiesi
Belongs to the E(R) family.Curated
Phylogenomic databases
eggNOGi | KOG1766, Eukaryota |
GeneTreei | ENSGT00390000003316 |
HOGENOMi | CLU_125703_1_0_1 |
InParanoidi | P84090 |
OMAi | RTWSDYE |
OrthoDBi | 1512482at2759 |
PhylomeDBi | P84090 |
TreeFami | TF314568 |
Family and domain databases
Gene3Di | 3.30.2260.10, 1 hit |
InterProi | View protein in InterPro IPR035912, EHR_sf IPR000781, ERH |
PANTHERi | PTHR12373, PTHR12373, 1 hit |
Pfami | View protein in Pfam PF01133, ER, 1 hit |
PIRSFi | PIRSF016393, Enh_rudimentary, 1 hit |
SUPFAMi | SSF143875, SSF143875, 1 hit |
PROSITEi | View protein in PROSITE PS01290, ER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P84090-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI
60 70 80 90 100
TYDISQLFDF IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ
QAGK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V279 | G3V279_HUMAN | Enhancer of rudimentary homolog | ERH | 71 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D85758 mRNA Translation: BAA12865.1 U66871 mRNA Translation: AAC51172.1 BT006877 mRNA Translation: AAP35523.1 AK312186 mRNA Translation: BAG35119.1 CH471061 Genomic DNA Translation: EAW80989.1 BC014301 mRNA Translation: AAH14301.1 BC071709 mRNA Translation: AAH71709.1 CR450298 mRNA Translation: CAG29294.1 CR542178 mRNA Translation: CAG46975.1 |
CCDSi | CCDS9794.1 |
RefSeqi | NP_004441.1, NM_004450.2 |
Genome annotation databases
Ensembli | ENST00000557016; ENSP00000451080; ENSG00000100632 |
GeneIDi | 2079 |
KEGGi | hsa:2079 |
UCSCi | uc001xlc.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D85758 mRNA Translation: BAA12865.1 U66871 mRNA Translation: AAC51172.1 BT006877 mRNA Translation: AAP35523.1 AK312186 mRNA Translation: BAG35119.1 CH471061 Genomic DNA Translation: EAW80989.1 BC014301 mRNA Translation: AAH14301.1 BC071709 mRNA Translation: AAH71709.1 CR450298 mRNA Translation: CAG29294.1 CR542178 mRNA Translation: CAG46975.1 |
CCDSi | CCDS9794.1 |
RefSeqi | NP_004441.1, NM_004450.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1W9G | X-ray | 2.00 | A/B | 1-104 | [»] | |
2NML | X-ray | 1.55 | A | 1-104 | [»] | |
7CNC | X-ray | 1.60 | A | 1-104 | [»] | |
SMRi | P84090 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108390, 143 interactors |
CORUMi | P84090 |
DIPi | DIP-42473N |
IntActi | P84090, 64 interactors |
MINTi | P84090 |
STRINGi | 9606.ENSP00000451080 |
PTM databases
iPTMneti | P84090 |
PhosphoSitePlusi | P84090 |
SwissPalmi | P84090 |
Genetic variation databases
BioMutai | ERH |
DMDMi | 51317296 |
Proteomic databases
EPDi | P84090 |
jPOSTi | P84090 |
MassIVEi | P84090 |
MaxQBi | P84090 |
PaxDbi | P84090 |
PeptideAtlasi | P84090 |
PRIDEi | P84090 |
ProteomicsDBi | 57749 |
TopDownProteomicsi | P84090 |
Protocols and materials databases
Antibodypediai | 117, 243 antibodies |
DNASUi | 2079 |
Genome annotation databases
Ensembli | ENST00000557016; ENSP00000451080; ENSG00000100632 |
GeneIDi | 2079 |
KEGGi | hsa:2079 |
UCSCi | uc001xlc.3, human |
Organism-specific databases
CTDi | 2079 |
DisGeNETi | 2079 |
GeneCardsi | ERH |
HGNCi | HGNC:3447, ERH |
HPAi | ENSG00000100632, Low tissue specificity |
MIMi | 601191, gene |
neXtProti | NX_P84090 |
OpenTargetsi | ENSG00000100632 |
PharmGKBi | PA27859 |
VEuPathDBi | HostDB:ENSG00000100632.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1766, Eukaryota |
GeneTreei | ENSGT00390000003316 |
HOGENOMi | CLU_125703_1_0_1 |
InParanoidi | P84090 |
OMAi | RTWSDYE |
OrthoDBi | 1512482at2759 |
PhylomeDBi | P84090 |
TreeFami | TF314568 |
Enzyme and pathway databases
PathwayCommonsi | P84090 |
Miscellaneous databases
BioGRID-ORCSi | 2079, 773 hits in 962 CRISPR screens |
ChiTaRSi | ERH, human |
EvolutionaryTracei | P84090 |
GeneWikii | ERH_(gene) |
GenomeRNAii | 2079 |
Pharosi | P84090, Tbio |
PROi | PR:P84090 |
RNActi | P84090, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100632, Expressed in pituitary gland and 251 other tissues |
ExpressionAtlasi | P84090, baseline and differential |
Genevisiblei | P84090, HS |
Family and domain databases
Gene3Di | 3.30.2260.10, 1 hit |
InterProi | View protein in InterPro IPR035912, EHR_sf IPR000781, ERH |
PANTHERi | PTHR12373, PTHR12373, 1 hit |
Pfami | View protein in Pfam PF01133, ER, 1 hit |
PIRSFi | PIRSF016393, Enh_rudimentary, 1 hit |
SUPFAMi | SSF143875, SSF143875, 1 hit |
PROSITEi | View protein in PROSITE PS01290, ER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERH_HUMAN | |
Accessioni | P84090Primary (citable) accession number: P84090 Secondary accession number(s): B2R5H2, P70659, Q14259 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families