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Protein

ADP-ribosylation factor 5

Gene

ARF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTP8
Nucleotide bindingi67 – 71GTP5
Nucleotide bindingi126 – 129GTP4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 5
Gene namesi
Name:ARF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000004059.10
HGNCiHGNC:658 ARF5
MIMi103188 gene
neXtProtiNX_P84085

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000004059
PharmGKBiPA24941

Chemistry databases

ChEMBLiCHEMBL5986

Polymorphism and mutation databases

BioMutaiARF5
DMDMi51316990

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002073962 – 180ADP-ribosylation factor 5Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP84085
MaxQBiP84085
PaxDbiP84085
PeptideAtlasiP84085
PRIDEiP84085
ProteomicsDBi57748
TopDownProteomicsiP84085

PTM databases

iPTMnetiP84085
PhosphoSitePlusiP84085
SwissPalmiP84085

Expressioni

Gene expression databases

BgeeiENSG00000004059 Expressed in 88 organ(s), highest expression level in frontal cortex
CleanExiHS_ARF5
ExpressionAtlasiP84085 baseline and differential
GenevisibleiP84085 HS

Interactioni

Subunit structurei

Binds ASAP2. Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4.4 Publications

Protein-protein interaction databases

BioGridi106876, 66 interactors
DIPiDIP-61289N
IntActiP84085, 11 interactors
MINTiP84085
STRINGi9606.ENSP00000000233

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP84085
SMRiP84085
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84085

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP84085
KOiK07940
OMAiMVQEDEL
OrthoDBiEOG091G0S7S
PhylomeDBiP84085
TreeFamiTF300808

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P84085-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLTVSALFS RIFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
QESADELQKM LQEDELRDAV LLVFANKQDM PNAMPVSELT DKLGLQHLRS
160 170 180
RTWYVQATCA TQGTGLYDGL DWLSHELSKR
Length:180
Mass (Da):20,530
Last modified:January 23, 2007 - v2
Checksum:i25EF3D4895408147
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1Z8C9J1Z8_HUMAN
ADP-ribosylation factor 5
ARF5
150Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57567 mRNA Translation: AAA90927.1
U73002 Genomic DNA Translation: AAC51299.1
AF493884 mRNA Translation: AAM12598.1
BT007087 mRNA Translation: AAP35750.1
BC003043 mRNA Translation: AAH03043.1
BC033104 mRNA Translation: AAH33104.1
CCDSiCCDS34745.1
PIRiA23741
RefSeqiNP_001653.1, NM_001662.3
UniGeneiHs.653202

Genome annotation databases

EnsembliENST00000000233; ENSP00000000233; ENSG00000004059
GeneIDi381
KEGGihsa:381
UCSCiuc003vmb.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57567 mRNA Translation: AAA90927.1
U73002 Genomic DNA Translation: AAC51299.1
AF493884 mRNA Translation: AAM12598.1
BT007087 mRNA Translation: AAP35750.1
BC003043 mRNA Translation: AAH03043.1
BC033104 mRNA Translation: AAH33104.1
CCDSiCCDS34745.1
PIRiA23741
RefSeqiNP_001653.1, NM_001662.3
UniGeneiHs.653202

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6HX-ray1.76A8-180[»]
ProteinModelPortaliP84085
SMRiP84085
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106876, 66 interactors
DIPiDIP-61289N
IntActiP84085, 11 interactors
MINTiP84085
STRINGi9606.ENSP00000000233

Chemistry databases

ChEMBLiCHEMBL5986

PTM databases

iPTMnetiP84085
PhosphoSitePlusiP84085
SwissPalmiP84085

Polymorphism and mutation databases

BioMutaiARF5
DMDMi51316990

Proteomic databases

EPDiP84085
MaxQBiP84085
PaxDbiP84085
PeptideAtlasiP84085
PRIDEiP84085
ProteomicsDBi57748
TopDownProteomicsiP84085

Protocols and materials databases

DNASUi381
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000000233; ENSP00000000233; ENSG00000004059
GeneIDi381
KEGGihsa:381
UCSCiuc003vmb.3 human

Organism-specific databases

CTDi381
EuPathDBiHostDB:ENSG00000004059.10
GeneCardsiARF5
HGNCiHGNC:658 ARF5
MIMi103188 gene
neXtProtiNX_P84085
OpenTargetsiENSG00000004059
PharmGKBiPA24941
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP84085
KOiK07940
OMAiMVQEDEL
OrthoDBiEOG091G0S7S
PhylomeDBiP84085
TreeFamiTF300808

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiARF5 human
EvolutionaryTraceiP84085
GeneWikiiARF5
GenomeRNAii381
PROiPR:P84085
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004059 Expressed in 88 organ(s), highest expression level in frontal cortex
CleanExiHS_ARF5
ExpressionAtlasiP84085 baseline and differential
GenevisibleiP84085 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARF5_HUMAN
AccessioniPrimary (citable) accession number: P84085
Secondary accession number(s): P26437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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