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Protein

Neuron-specific calcium-binding protein hippocalcin

Gene

HPCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi73 – 841Combined sources1 PublicationAdd BLAST12
Calcium bindingi109 – 1202Combined sources1 PublicationAdd BLAST12
Calcium bindingi157 – 1683Combined sources1 PublicationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • kinase binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuron-specific calcium-binding protein hippocalcinCurated
Alternative name(s):
Calcium-binding protein BDR-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HPCAImported
Synonyms:BDR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121905.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5144 HPCA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142622 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P84074

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystonia 2, torsion, autosomal recessive (DYT2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of torsion dystonia, a disease defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. 'Torsion' refers to the twisting nature of body movements, often affecting the trunk. DYT2 is a slowly progressive form that first affects distal limbs and later involves the neck, orofacial, and craniocervical regions.
See also OMIM:224500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07380371T → N in DYT2; no effect on protein localization; no effect on protein abundance; no effect on protein stability; no effect on protein 3D structure; decreased oligomerization; changed calcium-binding; effect on cooperativity for calcium-binding; no effect on affinity for calcium; no effect on interaction with voltage-dependent calcium channels. 2 PublicationsCorresponds to variant dbSNP:rs775863165EnsemblClinVar.1
Natural variantiVAR_07380475N → K in DYT2. 1 PublicationCorresponds to variant dbSNP:rs786205675EnsemblClinVar.1
Natural variantiVAR_073805190A → T in DYT2; no effect on protein localization; no effect on protein abundance; no effect on protein stability; no effect on protein 3D structure; decreased oligomerization; no effect on calcium-binding; no effect on affinity for calcium; increased interaction with voltage-dependent calcium channels. 2 PublicationsCorresponds to variant dbSNP:rs550921485EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dystonia

Organism-specific databases

DisGeNET

More...
DisGeNETi
3208

MalaCards human disease database

More...
MalaCardsi
HPCA
MIMi224500 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000121905

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99657 Primary dystonia, DYT2 type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29417

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HPCA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51317406

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000737682 – 193Neuron-specific calcium-binding protein hippocalcinAdd BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Myristoylation facilitates association with membranes.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P84074

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P84074

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P84074

PeptideAtlas

More...
PeptideAtlasi
P84074

PRoteomics IDEntifications database

More...
PRIDEi
P84074

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57746

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P84074

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P84074

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P84074

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121905 Expressed in 151 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

More...
CleanExi
HS_HPCA

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P84074 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012340
HPA043245

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer; oligomerization is calcium-dependent (PubMed:28398555). May interact with the voltage-dependent P/Q- and N-type calcium channels CACNA1A and CACNA1B (PubMed:28398555).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CREMQ03060-254EBI-12197079,EBI-12884642

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109448, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P84074, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362566

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P84074

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P84074

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 59EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds 3 calcium via EF-hand domains. The cryptic EF-hand 1 does not bind calcium.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0044 Eukaryota
COG5126 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158110

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233019

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108179

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P84074

Identification of Orthologs from Complete Genome Data

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OMAi
RTFDTNN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G11T4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P84074

TreeFam database of animal gene trees

More...
TreeFami
TF300009

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00036 EF-hand_1, 1 hit
PF13499 EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P84074-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK
110 120 130 140 150
LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,427
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DBEA176AC945DB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94R → P in BAA04019 (PubMed:8166736).Curated1
Sequence conflicti190A → R in BAA04019 (PubMed:8166736).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04866221E → D. Corresponds to variant dbSNP:rs11554958Ensembl.1
Natural variantiVAR_07380371T → N in DYT2; no effect on protein localization; no effect on protein abundance; no effect on protein stability; no effect on protein 3D structure; decreased oligomerization; changed calcium-binding; effect on cooperativity for calcium-binding; no effect on affinity for calcium; no effect on interaction with voltage-dependent calcium channels. 2 PublicationsCorresponds to variant dbSNP:rs775863165EnsemblClinVar.1
Natural variantiVAR_07380475N → K in DYT2. 1 PublicationCorresponds to variant dbSNP:rs786205675EnsemblClinVar.1
Natural variantiVAR_073805190A → T in DYT2; no effect on protein localization; no effect on protein abundance; no effect on protein stability; no effect on protein 3D structure; decreased oligomerization; no effect on calcium-binding; no effect on affinity for calcium; increased interaction with voltage-dependent calcium channels. 2 PublicationsCorresponds to variant dbSNP:rs550921485EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D16593 mRNA Translation: BAA04019.1
AB015202 Genomic DNA Translation: BAA74456.1
AK313907 mRNA Translation: BAG36630.1
CH471059 Genomic DNA Translation: EAX07495.1
CH471059 Genomic DNA Translation: EAX07496.1
CH471059 Genomic DNA Translation: EAX07498.1
BC001777 mRNA Translation: AAH01777.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS370.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC2186

NCBI Reference Sequences

More...
RefSeqi
NP_002134.2, NM_002143.2
XP_005270849.1, XM_005270792.2
XP_016856607.1, XM_017001118.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632391

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373467; ENSP00000362566; ENSG00000121905

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3208

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3208

UCSC genome browser

More...
UCSCi
uc001bwh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16593 mRNA Translation: BAA04019.1
AB015202 Genomic DNA Translation: BAA74456.1
AK313907 mRNA Translation: BAG36630.1
CH471059 Genomic DNA Translation: EAX07495.1
CH471059 Genomic DNA Translation: EAX07496.1
CH471059 Genomic DNA Translation: EAX07498.1
BC001777 mRNA Translation: AAH01777.1
CCDSiCCDS370.1
PIRiJC2186
RefSeqiNP_002134.2, NM_002143.2
XP_005270849.1, XM_005270792.2
XP_016856607.1, XM_017001118.1
UniGeneiHs.632391

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5G4PX-ray2.42A/E1-193[»]
5G58X-ray2.54A/E1-193[»]
5M6CX-ray3.00A/E1-193[»]
ProteinModelPortaliP84074
SMRiP84074
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109448, 7 interactors
IntActiP84074, 10 interactors
STRINGi9606.ENSP00000362566

PTM databases

iPTMnetiP84074
PhosphoSitePlusiP84074
SwissPalmiP84074

Polymorphism and mutation databases

BioMutaiHPCA
DMDMi51317406

Proteomic databases

EPDiP84074
MaxQBiP84074
PaxDbiP84074
PeptideAtlasiP84074
PRIDEiP84074
ProteomicsDBi57746

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3208
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373467; ENSP00000362566; ENSG00000121905
GeneIDi3208
KEGGihsa:3208
UCSCiuc001bwh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3208
DisGeNETi3208
EuPathDBiHostDB:ENSG00000121905.9

GeneCards: human genes, protein and diseases

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GeneCardsi
HPCA
HGNCiHGNC:5144 HPCA
HPAiCAB012340
HPA043245
MalaCardsiHPCA
MIMi142622 gene
224500 phenotype
neXtProtiNX_P84074
OpenTargetsiENSG00000121905
Orphaneti99657 Primary dystonia, DYT2 type
PharmGKBiPA29417

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00940000158110
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiP84074
OMAiRTFDTNN
OrthoDBiEOG091G11T4
PhylomeDBiP84074
TreeFamiTF300009

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Hippocalcin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3208

Protein Ontology

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PROi
PR:P84074

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000121905 Expressed in 151 organ(s), highest expression level in caudate nucleus
CleanExiHS_HPCA
GenevisibleiP84074 HS

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHPCA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P84074
Secondary accession number(s): B2R9T3
, D3DPQ7, P32076, P41211, P70510
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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