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Entry version 151 (02 Jun 2021)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H2A

Gene

His2A

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:His2A
Synonyms:H2a
AND
ORF Names:CG31618
AND
ORF Names:CG33808
AND
ORF Names:CG33814
AND
ORF Names:CG33817
AND
ORF Names:CG33820
AND
ORF Names:CG33823
AND
ORF Names:CG33826
AND
ORF Names:CG33829
AND
ORF Names:CG33832
AND
ORF Names:CG33835
AND
ORF Names:CG33838
AND
ORF Names:CG33841
AND
ORF Names:CG33844
AND
ORF Names:CG33847
AND
ORF Names:CG33850
AND
ORF Names:CG33862
AND
ORF Names:CG33865
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001196, His2A
FBgn0051618, His2A:CG31618
FBgn0053808, His2A:CG33808
FBgn0053814, His2A:CG33814
FBgn0053817, His2A:CG33817
FBgn0053820, His2A:CG33820
FBgn0053823, His2A:CG33823
FBgn0053826, His2A:CG33826
FBgn0053829, His2A:CG33829
FBgn0053832, His2A:CG33832
FBgn0053835, His2A:CG33835
FBgn0053838, His2A:CG33838
FBgn0053841, His2A:CG33841
FBgn0053844, His2A:CG33844
FBgn0053847, His2A:CG33847
FBgn0053850, His2A:CG33850
FBgn0053862, His2A:CG33862
FBgn0053865, His2A:CG33865

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000552222 – 124Histone H2AAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine1 Publication1
Modified residuei36N6-succinyllysine1 Publication1
Modified residuei104N5-methylglutamineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei120Phosphothreonine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.3 Publications
Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P84051

PRoteomics IDEntifications database

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PRIDEi
P84051

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P84051

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0051618, Expressed in embryo and 17 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P84051, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
534102, 1 interactor
77146, 35 interactors

Database of interacting proteins

More...
DIPi
DIP-29504N

Protein interaction database and analysis system

More...
IntActi
P84051, 9 interactors

Molecular INTeraction database

More...
MINTi
P84051

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0091111

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P84051

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P84051

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1756, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000164494

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_062828_3_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P84051

Identification of Orthologs from Complete Genome Data

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OMAi
MSGRSKQ

Database of Orthologous Groups

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OrthoDBi
1504122at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P84051

Family and domain databases

Conserved Domains Database

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CDDi
cd00074, H2A, 1 hit

Database of protein disorder

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DisProti
DP01546

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009072, Histone-fold
IPR002119, Histone_H2A
IPR007125, Histone_H2A/H2B/H3
IPR032454, Histone_H2A_C
IPR032458, Histone_H2A_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00125, Histone, 1 hit
PF16211, Histone_H2A_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00620, HISTONEH2A

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00414, H2A, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47113, SSF47113, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00046, HISTONE_H2A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P84051-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKGGKV KGKAKSRSNR AGLQFPVGRI HRLLRKGNYA ERVGAGAPVY
60 70 80 90 100
LAAVMEYLAA EVLELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLSGV
110 120
TIAQGGVLPN IQAVLLPKKT EKKA
Length:124
Mass (Da):13,363
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i725BA63C393155F6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32431.1
X14215 Genomic DNA Translation: CAA32436.1
AE014134 Genomic DNA Translation: AAN11125.1
AE014134 Genomic DNA Translation: AAZ66488.1
AE014134 Genomic DNA Translation: AAZ66497.1
AE014134 Genomic DNA Translation: AAZ66502.1
AE014134 Genomic DNA Translation: AAZ66507.1
AE014134 Genomic DNA Translation: AAZ66512.1
AE014134 Genomic DNA Translation: AAZ66517.1
AE014134 Genomic DNA Translation: AAZ66522.1
AE014134 Genomic DNA Translation: AAZ66527.1
AE014134 Genomic DNA Translation: AAZ66532.1
AE014134 Genomic DNA Translation: AAZ66537.1
AE014134 Genomic DNA Translation: AAZ66542.1
AE014134 Genomic DNA Translation: AAZ66547.1
AE014134 Genomic DNA Translation: AAZ66552.1
AE014134 Genomic DNA Translation: AAZ66557.1
AE014134 Genomic DNA Translation: AAZ66577.1
AE014134 Genomic DNA Translation: AAZ66582.1

Protein sequence database of the Protein Information Resource

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PIRi
S10094, HSFF2

NCBI Reference Sequences

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RefSeqi
NP_001027292.1, NM_001032121.2
NP_001027301.1, NM_001032130.2
NP_001027306.1, NM_001032135.2
NP_001027311.1, NM_001032140.2
NP_001027316.1, NM_001032145.2
NP_001027321.1, NM_001032150.2
NP_001027326.1, NM_001032155.2
NP_001027331.1, NM_001032160.2
NP_001027336.1, NM_001032165.2
NP_001027341.1, NM_001032170.2
NP_001027346.1, NM_001032175.2
NP_001027351.1, NM_001032180.2
NP_001027356.1, NM_001032185.2
NP_001027361.1, NM_001032190.2
NP_001027381.1, NM_001032210.2
NP_001027386.1, NM_001032215.2
NP_724343.1, NM_165382.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085893; FBpp0085249; FBgn0051618
FBtr0091812; FBpp0091055; FBgn0053808
FBtr0091818; FBpp0091060; FBgn0053814
FBtr0091821; FBpp0091063; FBgn0053817
FBtr0091824; FBpp0091066; FBgn0053820
FBtr0091827; FBpp0091069; FBgn0053823
FBtr0091830; FBpp0091072; FBgn0053826
FBtr0091833; FBpp0091075; FBgn0053829
FBtr0091836; FBpp0091078; FBgn0053832
FBtr0091839; FBpp0091081; FBgn0053835
FBtr0091842; FBpp0091084; FBgn0053838
FBtr0091845; FBpp0091087; FBgn0053841
FBtr0091848; FBpp0091090; FBgn0053844
FBtr0091851; FBpp0091093; FBgn0053847
FBtr0091854; FBpp0091096; FBgn0053850
FBtr0091866; FBpp0091108; FBgn0053862
FBtr0091869; FBpp0091111; FBgn0053865

Database of genes from NCBI RefSeq genomes

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GeneIDi
318855
3771774
3771783
3771785
3772148
3772278
3772282
3772345
3772351
3772360
3772447
3772448
3772505
3772541
3772565
3772618
3772632

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG31618
dme:Dmel_CG33808
dme:Dmel_CG33814
dme:Dmel_CG33817
dme:Dmel_CG33820
dme:Dmel_CG33823
dme:Dmel_CG33826
dme:Dmel_CG33829
dme:Dmel_CG33832
dme:Dmel_CG33835
dme:Dmel_CG33838
dme:Dmel_CG33841
dme:Dmel_CG33844
dme:Dmel_CG33847
dme:Dmel_CG33850
dme:Dmel_CG33862
dme:Dmel_CG33865

UCSC genome browser

More...
UCSCi
CG31618-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32431.1
X14215 Genomic DNA Translation: CAA32436.1
AE014134 Genomic DNA Translation: AAN11125.1
AE014134 Genomic DNA Translation: AAZ66488.1
AE014134 Genomic DNA Translation: AAZ66497.1
AE014134 Genomic DNA Translation: AAZ66502.1
AE014134 Genomic DNA Translation: AAZ66507.1
AE014134 Genomic DNA Translation: AAZ66512.1
AE014134 Genomic DNA Translation: AAZ66517.1
AE014134 Genomic DNA Translation: AAZ66522.1
AE014134 Genomic DNA Translation: AAZ66527.1
AE014134 Genomic DNA Translation: AAZ66532.1
AE014134 Genomic DNA Translation: AAZ66537.1
AE014134 Genomic DNA Translation: AAZ66542.1
AE014134 Genomic DNA Translation: AAZ66547.1
AE014134 Genomic DNA Translation: AAZ66552.1
AE014134 Genomic DNA Translation: AAZ66557.1
AE014134 Genomic DNA Translation: AAZ66577.1
AE014134 Genomic DNA Translation: AAZ66582.1
PIRiS10094, HSFF2
RefSeqiNP_001027292.1, NM_001032121.2
NP_001027301.1, NM_001032130.2
NP_001027306.1, NM_001032135.2
NP_001027311.1, NM_001032140.2
NP_001027316.1, NM_001032145.2
NP_001027321.1, NM_001032150.2
NP_001027326.1, NM_001032155.2
NP_001027331.1, NM_001032160.2
NP_001027336.1, NM_001032165.2
NP_001027341.1, NM_001032170.2
NP_001027346.1, NM_001032175.2
NP_001027351.1, NM_001032180.2
NP_001027356.1, NM_001032185.2
NP_001027361.1, NM_001032190.2
NP_001027381.1, NM_001032210.2
NP_001027386.1, NM_001032215.2
NP_724343.1, NM_165382.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30C/G2-124[»]
2PYOX-ray2.43C/G2-121[»]
4QLCX-ray3.50C/G2-124[»]
4X23X-ray3.50C/G/M/Q16-117[»]
5WCUX-ray5.53C/G/M/Q15-118[»]
6DZTelectron microscopy2.99C/G1-124[»]
6PWEelectron microscopy3.95C/G1-124[»]
6PWFelectron microscopy4.07C/G1-124[»]
SMRiP84051
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi534102, 1 interactor
77146, 35 interactors
DIPiDIP-29504N
IntActiP84051, 9 interactors
MINTiP84051
STRINGi7227.FBpp0091111

PTM databases

iPTMnetiP84051

Proteomic databases

PaxDbiP84051
PRIDEiP84051

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P84051, 1 sequenced antibody

Genome annotation databases

EnsemblMetazoaiFBtr0085893; FBpp0085249; FBgn0051618
FBtr0091812; FBpp0091055; FBgn0053808
FBtr0091818; FBpp0091060; FBgn0053814
FBtr0091821; FBpp0091063; FBgn0053817
FBtr0091824; FBpp0091066; FBgn0053820
FBtr0091827; FBpp0091069; FBgn0053823
FBtr0091830; FBpp0091072; FBgn0053826
FBtr0091833; FBpp0091075; FBgn0053829
FBtr0091836; FBpp0091078; FBgn0053832
FBtr0091839; FBpp0091081; FBgn0053835
FBtr0091842; FBpp0091084; FBgn0053838
FBtr0091845; FBpp0091087; FBgn0053841
FBtr0091848; FBpp0091090; FBgn0053844
FBtr0091851; FBpp0091093; FBgn0053847
FBtr0091854; FBpp0091096; FBgn0053850
FBtr0091866; FBpp0091108; FBgn0053862
FBtr0091869; FBpp0091111; FBgn0053865
GeneIDi318855
3771774
3771783
3771785
3772148
3772278
3772282
3772345
3772351
3772360
3772447
3772448
3772505
3772541
3772565
3772618
3772632
KEGGidme:Dmel_CG31618
dme:Dmel_CG33808
dme:Dmel_CG33814
dme:Dmel_CG33817
dme:Dmel_CG33820
dme:Dmel_CG33823
dme:Dmel_CG33826
dme:Dmel_CG33829
dme:Dmel_CG33832
dme:Dmel_CG33835
dme:Dmel_CG33838
dme:Dmel_CG33841
dme:Dmel_CG33844
dme:Dmel_CG33847
dme:Dmel_CG33850
dme:Dmel_CG33862
dme:Dmel_CG33865
UCSCiCG31618-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
318855
3771774
3771783
3771785
3772148
3772278
3772282
3772345
3772351
3772360
3772447
3772448
3772505
3772541
3772565
3772618
3772632
FlyBaseiFBgn0001196, His2A
FBgn0051618, His2A:CG31618
FBgn0053808, His2A:CG33808
FBgn0053814, His2A:CG33814
FBgn0053817, His2A:CG33817
FBgn0053820, His2A:CG33820
FBgn0053823, His2A:CG33823
FBgn0053826, His2A:CG33826
FBgn0053829, His2A:CG33829
FBgn0053832, His2A:CG33832
FBgn0053835, His2A:CG33835
FBgn0053838, His2A:CG33838
FBgn0053841, His2A:CG33841
FBgn0053844, His2A:CG33844
FBgn0053847, His2A:CG33847
FBgn0053850, His2A:CG33850
FBgn0053862, His2A:CG33862
FBgn0053865, His2A:CG33865

Phylogenomic databases

eggNOGiKOG1756, Eukaryota
GeneTreeiENSGT00940000164494
HOGENOMiCLU_062828_3_3_1
InParanoidiP84051
OMAiMSGRSKQ
OrthoDBi1504122at2759
PhylomeDBiP84051

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
His2Av, fly
EvolutionaryTraceiP84051

Protein Ontology

More...
PROi
PR:P84051

Gene expression databases

BgeeiFBgn0051618, Expressed in embryo and 17 other tissues
GenevisibleiP84051, DM

Family and domain databases

CDDicd00074, H2A, 1 hit
DisProtiDP01546
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072, Histone-fold
IPR002119, Histone_H2A
IPR007125, Histone_H2A/H2B/H3
IPR032454, Histone_H2A_C
IPR032458, Histone_H2A_CS
PfamiView protein in Pfam
PF00125, Histone, 1 hit
PF16211, Histone_H2A_C, 1 hit
PRINTSiPR00620, HISTONEH2A
SMARTiView protein in SMART
SM00414, H2A, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046, HISTONE_H2A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2A_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P84051
Secondary accession number(s): P02267, Q4ABC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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