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Protein

U24-ctenitoxin-Pn1a

Gene
N/A
Organism
Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cysteine proteinase inhibitor.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
U24-ctenitoxin-Pn1a
Short name:
U24-CNTX-Pn1a
Alternative name(s):
Venom protein PN16C3
OrganismiPhoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Taxonomic identifieri6918 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeLycosoideaCtenidaePhoneutria

Organism-specific databases

ArachnoServeriAS000010 U24-ctenitoxin-Pn1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584751 – 128U24-ctenitoxin-Pn1aAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 27PROSITE-ProRule annotation
Disulfide bondi38 ↔ 45PROSITE-ProRule annotation
Disulfide bondi47 ↔ 67PROSITE-ProRule annotation
Disulfide bondi107 ↔ 127PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP84032
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 67Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST64
Domaini72 – 127Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00211 TY, 2 hits
SUPFAMiSSF57610 SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS51162 THYROGLOBULIN_1_2, 2 hits

Sequencei

Sequence statusi: Complete.

P84032-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ARPKSDCEKH RESTEKTGTI MKLIPKCKEN SDYEELQCYE DSKFCVCYDK
60 70 80 90 100
KGHAASPIST KVKECGCYLK QKERKDSGRE SAIIPQCEED GKWAKKQLWE
110 120
FNKSCWCVDE KGEQVGKIHH DCDSLKCE
Length:128
Mass (Da):14,788
Last modified:July 19, 2004 - v1
Checksum:i0CC710D7DBBB62CA
GO

Mass spectrometryi

Molecular mass is 14778.05±0.03 Da from positions 1 - 128. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti31S → G1 Publication1
Natural varianti119H → Y1 Publication1
Natural varianti126K → N1 Publication1

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP84032
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000010 U24-ctenitoxin-Pn1a

Family and domain databases

Gene3Di4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00211 TY, 2 hits
SUPFAMiSSF57610 SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS51162 THYROGLOBULIN_1_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPN16_PHONI
AccessioniPrimary (citable) accession number: P84032
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 25, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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