Mothers against decapentaplegic homolog 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: Ensembl
• chromatin DNA binding Source: Ensembl
• collagen binding Source: Ensembl
• co-SMAD binding Source: Ensembl
• DEAD/H-box RNA helicase binding Source: Ensembl
• DNA-binding transcription factor activity Source: UniProtKB
• glucocorticoid receptor binding Source: Ensembl
• mineralocorticoid receptor binding Source: Ensembl
• phosphatase binding Source: Ensembl
• primary miRNA binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• protein kinase binding Source: Ensembl
• proximal promoter sequence-specific DNA binding Source: UniProtKB
• RNA polymerase II activating transcription factor binding Source: Ensembl
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
• R-SMAD binding Source: Ensembl
• transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
• transcription coregulator activity Source: Ensembl
• transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
• transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Source: Ensembl
• transforming growth factor beta receptor binding Source: Ensembl
• ubiquitin binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl
• zinc ion binding Source: Ensembl

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• cell-cell junction organization Source: Ensembl
• cell cycle arrest Source: Ensembl
• developmental growth Source: Ensembl
• embryonic cranial skeleton morphogenesis Source: Ensembl
• embryonic foregut morphogenesis Source: Ensembl
• embryonic pattern specification Source: Ensembl
• endoderm development Source: Ensembl
• evasion or tolerance of host defenses by virus Source: Ensembl
• extrinsic apoptotic signaling pathway Source: Ensembl
• heart looping Source: Ensembl
• immune response Source: Ensembl
• immune system development Source: Ensembl
• in utero embryonic development Source: Ensembl
• lens fiber cell differentiation Source: Ensembl
• liver development Source: Ensembl
• mesoderm formation Source: Ensembl
• negative regulation of cell growth Source: Ensembl
• negative regulation of cytosolic calcium ion concentration Source: Ensembl
• negative regulation of fat cell differentiation Source: Ensembl
• negative regulation of inflammatory response Source: Ensembl
• negative regulation of mitotic cell cycle Source: Ensembl
• negative regulation of osteoblast differentiation Source: Ensembl
• negative regulation of osteoblast proliferation Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• negative regulation of wound healing Source: Ensembl
• nodal signaling pathway Source: Ensembl
• osteoblast development Source: Ensembl
• paraxial mesoderm morphogenesis Source: Ensembl
• pericardium development Source: Ensembl
• positive regulation of chondrocyte differentiation Source: Ensembl
• positive regulation of epithelial to mesenchymal transition Source: Ensembl
• positive regulation of extracellular matrix assembly Source: Ensembl
• positive regulation of nitric oxide biosynthetic process Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• regulation of binding Source: Ensembl
• regulation of epithelial cell proliferation Source: Ensembl
• regulation of immune response Source: Ensembl
• regulation of striated muscle tissue development Source: Ensembl
• regulation of transforming growth factor beta2 production Source: Ensembl
• regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
• response to hypoxia Source: Ensembl
• SMAD protein complex assembly Source: Ensembl
• SMAD protein signal transduction Source: Ensembl
• somitogenesis Source: Ensembl
• T cell activation Source: Ensembl
• thyroid gland development Source: Ensembl
• transforming growth factor beta receptor signaling pathway Source: UniProtKB
• ureteric bud development Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: Ensembl
• co-SMAD binding Source: Ensembl
• DEAD/H-box RNA helicase binding Source: Ensembl
• glucocorticoid receptor binding Source: Ensembl
• mineralocorticoid receptor binding Source: Ensembl
• phosphatase binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• protein kinase binding Source: Ensembl
• RNA polymerase II activating transcription factor binding Source: Ensembl
• R-SMAD binding Source: Ensembl
• transforming growth factor beta receptor binding Source: Ensembl
• ubiquitin binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE 
        60         70         80         90        100
LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH 
       110        120        130        140        150
HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF 
       160        170        180        190        200
PPLDDYSHSI PENTNFPAGI EPQSNIPETP PPGYLSEDGE TSDHQMNHSM 
       210        220        230        240        250
DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL NQRVGETFHA 
       260        270        280        290        300
SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG 
       310        320        330        340        350
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA 
       360        370        380        390        400
LLAQSVNQGF EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL 
       410        420 
NGPLQWLDKV LTQMGSPSIR CSSVS                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ