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Protein

Mothers against decapentaplegic homolog 3

Gene

SMAD3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64ZincBy similarity1
Metal bindingi109ZincBy similarity1
Metal bindingi121ZincBy similarity1
Metal bindingi126ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homolog 3
Short name:
MAD homolog 3
Short name:
Mad3
Short name:
Mothers against DPP homolog 3
Alternative name(s):
SMAD family member 3
Short name:
SMAD 3
Short name:
Smad3
Gene namesi
Name:SMAD3
Synonyms:MADH3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000908601 – 426Mothers against decapentaplegic homolog 3Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei424PhosphoserinePROSITE-ProRule annotation1
Modified residuei426PhosphoserinePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP84023

Expressioni

Gene expression databases

BgeeiENSGALG00000007870 Expressed in 11 organ(s), highest expression level in kidney

Interactioni

Subunit structurei

Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co-SMAD SMAD4.By similarity

Protein-protein interaction databases

BioGridi675429, 2 interactors
STRINGi9031.ENSGALP00000012766

Structurei

3D structure databases

ProteinModelPortaliP84023
SMRiP84023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 136MH1PROSITE-ProRule annotationAdd BLAST127
Domaini233 – 426MH2PROSITE-ProRule annotationAdd BLAST194

Domaini

The MH2 domain is sufficient to carry protein nuclear export.By similarity

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.Curated

Phylogenomic databases

eggNOGiKOG3701 Eukaryota
ENOG410XQKU LUCA
HOGENOMiHOG000286018
HOVERGENiHBG053353
InParanoidiP84023
KOiK04500
OMAiSDHQMTH
OrthoDBiEOG091G082C
PhylomeDBiP84023
TreeFamiTF314923

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 1 hit
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P84023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE
60 70 80 90 100
LEKAITTQNI NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH
110 120 130 140 150
HELRAMEMCE YAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF
160 170 180 190 200
PPLDDYSHSI PENTNFPAGI EPQSNYIPET PPPGYLSEDG ETSDHQMNPS
210 220 230 240 250
MDAGSPNLSP NPMSPAHNNL DLQPVTYCEP AFWCSISYYE LNQRVGETFH
260 270 280 290 300
ASQPSMTVDG FTDPSNSERF CLGLLSNVNR NAAVELTRRH IGRGVRLYYI
310 320 330 340 350
GGEVFAECLS DSAIFVQSPN CNQRYGWHPA TVCKIPPGCN LKIFNNQEFA
360 370 380 390 400
ALLAQSVNQG FEAVYQLTRM CTIRMSFVKG WGAEYRRQTV TSTPCWIELH
410 420
LNGPLQWLDK VLTQMGSPSI RCSSVS
Length:426
Mass (Da):48,252
Last modified:July 5, 2004 - v1
Checksum:i58DC1F9A664EAC7C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5PSS6A0A1D5PSS6_CHICK
Mothers against decapentaplegic hom...
SMAD3
456Annotation score:
A0A1D5PYM1A0A1D5PYM1_CHICK
Mothers against decapentaplegic hom...
SMAD3
399Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY391265 mRNA Translation: AAQ89726.1
RefSeqiNP_989806.1, NM_204475.1
UniGeneiGga.28197

Genome annotation databases

GeneIDi395132
KEGGigga:395132

Similar proteinsi

Entry informationi

Entry nameiSMAD3_CHICK
AccessioniPrimary (citable) accession number: P84023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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