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Protein

Homeotic protein ultrabithorax

Gene

Ubx

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi295 – 354HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP83949

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein ultrabithorax
Gene namesi
Name:Ubx
ORF Names:CG10388
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003944 Ubx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002681 – 389Homeotic protein ultrabithoraxAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170Phosphothreonine1 Publication1
Modified residuei174Phosphoserine1 Publication1
Modified residuei177Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP83949
PRIDEiP83949

PTM databases

iPTMnetiP83949

Expressioni

Tissue specificityi

In the embryo, expression is seen in the epidermis, somatic and visceral mesoderm, and the peripheral and central nervous system.1 Publication

Gene expression databases

BgeeiFBgn0003944 Expressed in 19 organ(s), highest expression level in embryo
ExpressionAtlasiP83949 baseline and differential
GenevisibleiP83949 DM

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi67078, 110 interactors
DIPiDIP-33048N
IntActiP83949, 28 interactors
MINTiP83949
STRINGi7227.FBpp0082793

Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00623
ProteinModelPortaliP83949
SMRiP83949
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83949

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi239 – 244Antp-type hexapeptide6
Motifi368 – 383QAAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 39Poly-Ala7
Compositional biasi111 – 129Poly-GlyAdd BLAST19
Compositional biasi322 – 325Poly-Arg4

Domaini

The QA motif is able to mediate transcriptional repression.By similarity

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
InParanoidiP83949
KOiK09311
OMAiYGSHHHQ
OrthoDBiEOG091G0P0U
PhylomeDBiP83949

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform IB (identifier: P83949-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS
60 70 80 90 100
PYANHHLQRT TQDSPYDASI TAACNKIYGD GAGAYKQDCL NIKADAVNGY
110 120 130 140 150
KDIWNTGGSN GGGGGGGGGG GGGAGGTGGA GNANGGNAAN ANGQNNPAGG
160 170 180 190 200
MPVRPSACTP DSRVGGYLDT SGGSPVSHRG GSAGGNVSVS GGNGNAGGVQ
210 220 230 240 250
SGVGVAGAGT AWNANCTISG AAAQTAAASS LHQASNHTFY PWMAIAGECP
260 270 280 290 300
EDPTKSKIRS DLTQYGGIST DMGKRYSESL AGSLLPDWLG TNGLRRRGRQ
310 320 330 340 350
TYTRYQTLEL EKEFHTNHYL TRRRRIEMAH ALCLTERQIK IWFQNRRMKL
360 370 380
KKEIQAIKEL NEQEKQAQAQ KAAAAAAAAA AVQGGHLDQ
Length:389
Mass (Da):40,040
Last modified:June 7, 2004 - v1
Checksum:iD452E8FFE55D8F53
GO
Isoform IA (identifier: P83949-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     248-256: Missing.

Show »
Length:380
Mass (Da):39,053
Checksum:iB8A8FE2B19724E28
GO
Isoform IIA (identifier: P83949-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     248-273: Missing.

Show »
Length:363
Mass (Da):37,229
Checksum:i55DD2D46391F1FC6
GO
Isoform IIB (identifier: P83949-4) [UniParc] [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     258-274: Missing.

Show »
Length:372
Mass (Da):38,216
Checksum:iA58E24FA4415FD4C
GO
Isoform IVA (identifier: P83949-5) [UniParc] [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     248-290: Missing.

Show »
Length:346
Mass (Da):35,355
Checksum:i4D4610EC2BA13E05
GO
Isoform IVB (identifier: P83949-6) [UniParc] [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     257-290: Missing.

Show »
Length:355
Mass (Da):36,342
Checksum:i9C764B4C095711D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75N → Y in AAA84412 (PubMed:7667301).Curated1
Sequence conflicti75N → Y in AAA84411 (PubMed:7667301).Curated1
Sequence conflicti75N → Y in AAA84410 (PubMed:7667301).Curated1
Sequence conflicti75N → Y in AAA84409 (PubMed:7667301).Curated1
Sequence conflicti75N → Y in AAA84408 (PubMed:7667301).Curated1
Sequence conflicti330H → Y in AAA28615 (PubMed:6327065).Curated1
Sequence conflicti340K → E in AAA28615 (PubMed:6327065).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002407248 – 290Missing in isoform IVA. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_002406248 – 273Missing in isoform IIA. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_002405248 – 256Missing in isoform IA. 2 Publications9
Alternative sequenceiVSP_002409257 – 290Missing in isoform IVB. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_002408258 – 274Missing in isoform IIB. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05723
, X05724, X05725, X05727 Genomic DNA Translation: CAA29194.1
X76210 mRNA Translation: CAA53803.1
U31961 Genomic DNA Translation: AAA84412.1
U31961 Genomic DNA Translation: AAA84411.1
U31961 Genomic DNA Translation: AAA84410.1
U31961 Genomic DNA Translation: AAA84409.1
U31961 Genomic DNA Translation: AAA84408.1
AE014297 Genomic DNA Translation: AAF55355.2
AE014297 Genomic DNA Translation: AAF55356.1
AE014297 Genomic DNA Translation: AAN13717.1
AE014297 Genomic DNA Translation: AAN13718.1
AE014297 Genomic DNA Translation: AAN13719.1
AE014297 Genomic DNA Translation: AAS65158.1
BT010241 mRNA Translation: AAQ23559.1
K01963 Genomic DNA Translation: AAA29008.1 Sequence problems.
K01959 Genomic DNA Translation: AAA28615.1 Sequence problems.
X05427 Genomic DNA Translation: CAA29009.1
PIRiB27867
D26995
RefSeqiNP_536748.1, NM_080500.4 [P83949-5]
NP_536752.1, NM_080504.4 [P83949-1]
NP_732171.1, NM_169728.3 [P83949-3]
NP_732172.1, NM_169729.3 [P83949-2]
NP_732173.1, NM_169730.3 [P83949-4]
NP_996219.1, NM_206497.3 [P83949-6]
UniGeneiDm.21668

Genome annotation databases

EnsemblMetazoaiFBtr0083347; FBpp0082793; FBgn0003944 [P83949-1]
FBtr0083348; FBpp0082794; FBgn0003944 [P83949-5]
FBtr0083349; FBpp0082795; FBgn0003944 [P83949-4]
FBtr0083350; FBpp0082796; FBgn0003944 [P83949-3]
FBtr0083351; FBpp0082797; FBgn0003944 [P83949-2]
FBtr0083352; FBpp0089155; FBgn0003944 [P83949-6]
GeneIDi42034
KEGGidme:Dmel_CG10388

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05723
, X05724, X05725, X05727 Genomic DNA Translation: CAA29194.1
X76210 mRNA Translation: CAA53803.1
U31961 Genomic DNA Translation: AAA84412.1
U31961 Genomic DNA Translation: AAA84411.1
U31961 Genomic DNA Translation: AAA84410.1
U31961 Genomic DNA Translation: AAA84409.1
U31961 Genomic DNA Translation: AAA84408.1
AE014297 Genomic DNA Translation: AAF55355.2
AE014297 Genomic DNA Translation: AAF55356.1
AE014297 Genomic DNA Translation: AAN13717.1
AE014297 Genomic DNA Translation: AAN13718.1
AE014297 Genomic DNA Translation: AAN13719.1
AE014297 Genomic DNA Translation: AAS65158.1
BT010241 mRNA Translation: AAQ23559.1
K01963 Genomic DNA Translation: AAA29008.1 Sequence problems.
K01959 Genomic DNA Translation: AAA28615.1 Sequence problems.
X05427 Genomic DNA Translation: CAA29009.1
PIRiB27867
D26995
RefSeqiNP_536748.1, NM_080500.4 [P83949-5]
NP_536752.1, NM_080504.4 [P83949-1]
NP_732171.1, NM_169728.3 [P83949-3]
NP_732172.1, NM_169729.3 [P83949-2]
NP_732173.1, NM_169730.3 [P83949-4]
NP_996219.1, NM_206497.3 [P83949-6]
UniGeneiDm.21668

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8IX-ray2.40A233-356[»]
4CYCX-ray2.36A233-367[»]
4UUSX-ray2.55A/E292-367[»]
4UUTX-ray2.80A233-367[»]
DisProtiDP00623
ProteinModelPortaliP83949
SMRiP83949
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67078, 110 interactors
DIPiDIP-33048N
IntActiP83949, 28 interactors
MINTiP83949
STRINGi7227.FBpp0082793

PTM databases

iPTMnetiP83949

Proteomic databases

PaxDbiP83949
PRIDEiP83949

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083347; FBpp0082793; FBgn0003944 [P83949-1]
FBtr0083348; FBpp0082794; FBgn0003944 [P83949-5]
FBtr0083349; FBpp0082795; FBgn0003944 [P83949-4]
FBtr0083350; FBpp0082796; FBgn0003944 [P83949-3]
FBtr0083351; FBpp0082797; FBgn0003944 [P83949-2]
FBtr0083352; FBpp0089155; FBgn0003944 [P83949-6]
GeneIDi42034
KEGGidme:Dmel_CG10388

Organism-specific databases

CTDi42034
FlyBaseiFBgn0003944 Ubx

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
InParanoidiP83949
KOiK09311
OMAiYGSHHHQ
OrthoDBiEOG091G0P0U
PhylomeDBiP83949

Enzyme and pathway databases

SignaLinkiP83949

Miscellaneous databases

ChiTaRSiUbx fly
EvolutionaryTraceiP83949
GenomeRNAii42034
PROiPR:P83949

Gene expression databases

BgeeiFBgn0003944 Expressed in 19 organ(s), highest expression level in embryo
ExpressionAtlasiP83949 baseline and differential
GenevisibleiP83949 DM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBX_DROME
AccessioniPrimary (citable) accession number: P83949
Secondary accession number(s): P02834
, Q9TX83, Q9VER4, Q9VER5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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